CA2397862C - Storage solution containing photosensitizer for inactivation of biological contaminants - Google Patents

Storage solution containing photosensitizer for inactivation of biological contaminants Download PDF

Info

Publication number
CA2397862C
CA2397862C CA2397862A CA2397862A CA2397862C CA 2397862 C CA2397862 C CA 2397862C CA 2397862 A CA2397862 A CA 2397862A CA 2397862 A CA2397862 A CA 2397862A CA 2397862 C CA2397862 C CA 2397862C
Authority
CA
Canada
Prior art keywords
blood
concentration
photosensitizer
dimethyl
bag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2397862A
Other languages
English (en)
French (fr)
Other versions
CA2397862A1 (en
Inventor
Laura Mcburney
Raymond P. Goodrich, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Biotechnologies LLC
Original Assignee
Terumo BCT Biotechnologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo BCT Biotechnologies LLC filed Critical Terumo BCT Biotechnologies LLC
Publication of CA2397862A1 publication Critical patent/CA2397862A1/en
Application granted granted Critical
Publication of CA2397862C publication Critical patent/CA2397862C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/124—Disinfecting agents, e.g. antimicrobials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dentistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2397862A 2000-11-28 2001-11-21 Storage solution containing photosensitizer for inactivation of biological contaminants Expired - Lifetime CA2397862C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/725,426 US6548241B1 (en) 2000-11-28 2000-11-28 Storage solution containing photosensitizer for inactivation of biological contaminants
US09/725,426 2000-11-28
PCT/US2001/043591 WO2002043485A1 (en) 2000-11-28 2001-11-21 Storage solution containing photosensitizer for inactivation of biological contaminants

Publications (2)

Publication Number Publication Date
CA2397862A1 CA2397862A1 (en) 2002-06-06
CA2397862C true CA2397862C (en) 2013-04-16

Family

ID=24914504

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2397862A Expired - Lifetime CA2397862C (en) 2000-11-28 2001-11-21 Storage solution containing photosensitizer for inactivation of biological contaminants

Country Status (8)

Country Link
US (2) US6548241B1 (enExample)
EP (1) EP1345491B1 (enExample)
JP (1) JP4473508B2 (enExample)
AT (1) ATE322162T1 (enExample)
AU (1) AU2002225687A1 (enExample)
CA (1) CA2397862C (enExample)
DE (1) DE60118604T2 (enExample)
WO (1) WO2002043485A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215784A1 (en) * 1998-07-21 2003-11-20 Dumont Larry Joe Method and apparatus for inactivation of biological contaminants using photosensitizers
US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US7220747B2 (en) * 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US7094378B1 (en) * 2000-06-15 2006-08-22 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US6969367B2 (en) * 2000-02-02 2005-11-29 Xepmed, Inc. Extracorporeal pathogen reduction system
US7470245B2 (en) * 2000-02-02 2008-12-30 Xepmed, Inc. Extracorporeal pathogen reduction system
US6936413B1 (en) * 2001-12-05 2005-08-30 Baxter International Inc. Methods and systems for preparing blood products
US7183045B2 (en) * 2002-04-24 2007-02-27 Gambro Inc. Removal of adenine during a pathogen reduction process in whole blood or red blood cell by dilution
CA2524712A1 (en) * 2003-06-20 2004-12-29 Pall Corporation Processing of platelet-containing biological fluids
US20070102858A1 (en) * 2005-11-07 2007-05-10 Navigant Biotechnologies, Inc. Clamps and methods for displacing fluid from portions of fluid containers
CA2629340A1 (en) * 2005-12-06 2007-06-14 Navigant Biotechnologies, Llc Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
EP1976852A1 (en) 2006-01-27 2008-10-08 CaridianBCT Biotechnologies, LLC Methods and compositions for the production of high concentration alloxazine solutions
AU2012233032B2 (en) * 2006-01-27 2015-07-16 Terumo Bct Biotechnologies, Llc Methods and compositions for the production of high concentration alloxazine solutions
US20080234622A1 (en) * 2007-03-20 2008-09-25 Gambro Bct Inc. Methods and Systems for Preparing Blood Products
US8835104B2 (en) * 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US20100190676A1 (en) * 2008-07-22 2010-07-29 Ecolab Inc. Composition for enhanced removal of blood soils
WO2010039994A2 (en) * 2008-10-01 2010-04-08 Caridianbct, Inc. Platelet additive solution for leukoreducing white blood cells in apheresed platelets
WO2010048572A1 (en) 2008-10-23 2010-04-29 Cornell University A novel anti-viral method
US8715920B2 (en) 2010-07-27 2014-05-06 Biovec Transfusion, Llc Composition for preserving platelets during photosensitization
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11864553B2 (en) 2009-10-23 2024-01-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
AU2012240016B2 (en) 2011-04-07 2016-11-10 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
EP4190154A1 (en) * 2011-07-05 2023-06-07 Hemanext Inc. A system for extended storage of red blood cells
US8940228B2 (en) 2012-01-11 2015-01-27 Terumo Bct, Inc. Slidable clamp for port isolation
US9289546B2 (en) * 2012-08-16 2016-03-22 Dirk Jerome Erickson Exsanguination preventing device
WO2015191599A2 (en) 2014-06-09 2015-12-17 Terumo Bct, Inc. Lyophilization
WO2016145210A1 (en) 2015-03-10 2016-09-15 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
IL285359B2 (en) 2015-04-23 2024-01-01 Hemanext Inc Anaerobic blood storage containers
US20190099543A1 (en) 2016-03-23 2019-04-04 Terumo Kabushiki Kaisha Light irradiation device
IL273433B2 (en) * 2017-09-20 2025-01-01 Cerus Corp Compositions and methods for inactivating platelet pathogens

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786014A (en) 1952-09-10 1957-03-19 James L Tullis Platelet preservation
US3629071A (en) 1970-02-10 1971-12-21 Upjohn Co Storage-stable hemostatic transfusion suspensions of blood platelets, glucose, magnesium chloride and certain prostaglandins
US3874384A (en) 1971-11-01 1975-04-01 American Hospital Supply Corp Improved blood storage unit and method of storing blood
DE2532183C3 (de) 1975-07-18 1982-03-04 Behringwerke Ag, 3550 Marburg Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen
US4112070A (en) 1977-06-08 1978-09-05 Research Corporation Blood preservation system
GB2034463B (en) 1978-11-11 1983-03-30 Ryan W Plaetelet reference control
US4267269A (en) 1980-02-05 1981-05-12 Baxter Travenol Laboratories, Inc. Red cell storage solution
US4568542A (en) 1981-06-09 1986-02-04 Lee Biomolecular Research Laboratories, Inc. Vaccine compositions
US4390619A (en) 1981-09-28 1983-06-28 James Clifford Haight Leukocyte or platelet storage using ion-exchange resins
JPS5862333A (ja) * 1981-10-09 1983-04-13 Mazda Motor Corp エンジンのアイドル回転制御装置
US4432750A (en) 1981-12-02 1984-02-21 Baxter Travenol Laboratories, Inc. Additive sterol solution and method for preserving normal red cell morphology in whole blood during storage
DE3225408A1 (de) 1982-07-07 1984-01-12 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
CA1216518A (en) 1982-11-01 1987-01-13 Gail A. Rock Plasma-free medium for platelet storage
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4609372A (en) 1983-10-13 1986-09-02 Miles Laboratories, Inc. Heat sterilizable storage solution for red blood cells
GB8328495D0 (en) 1983-10-25 1983-11-23 Wellcome Found Pharmacologically active ketones
CA1244774A (en) * 1983-11-09 1988-11-15 Thomas Jefferson University Medium for storing blood platelets
US4828976A (en) 1983-12-29 1989-05-09 Thomas Jefferson University Glucose free media for storing blood platelets
US4992363A (en) 1983-11-09 1991-02-12 Thomas Jefferson University Method for preparing glucose free media for storing blood platelets
US4585735A (en) 1984-07-19 1986-04-29 American National Red Cross Prolonged storage of red blood cells
JPS61275228A (ja) 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化
US4704352A (en) 1985-06-25 1987-11-03 Baxter Travenol Laboratories, Inc. L-ascorbate-2-phosphate salts in blood cell storage
US4675185A (en) 1985-12-06 1987-06-23 Baxter Travenol Laboratories, Inc. Solution for stabilizing red blood cells during storage
US5281392A (en) 1986-03-10 1994-01-25 Rubinstein Alan I Method for disinfecting red blood cells, blood products, and corneas
US4695460A (en) * 1986-03-19 1987-09-22 American Red Cross Synthetic, plasma-free, transfusible platelet storage medium
US4961928A (en) 1986-03-19 1990-10-09 American Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
US5248506A (en) 1986-03-19 1993-09-28 American National Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
US4769318A (en) 1986-06-03 1988-09-06 Ube Industries, Ltd. Additive solution for blood preservation and activation
US4726949A (en) 1986-08-26 1988-02-23 Baxter Travenol Laboratories, Inc. Irradiation of blood products
DE3805459A1 (de) 1988-02-22 1989-08-31 Biotest Pharma Gmbh Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
US4994367A (en) 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
US5211960A (en) 1988-11-29 1993-05-18 Scripps Clinic And Research Foundation Stabilization of leukocytes
US5041078A (en) 1989-03-06 1991-08-20 Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas Photodynamic viral deactivation with sapphyrins
US4999375A (en) 1989-04-11 1991-03-12 Hoffmann-La Roche Inc. Psoralen reagent compositions for extracorporeal treatment of blood
US4925665A (en) 1989-06-22 1990-05-15 Thomas Jefferson University Glucose free primary anticoagulant for blood containing citrate ions
US5250303A (en) 1989-10-06 1993-10-05 The American National Red Cross Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG
US5236716A (en) 1990-02-12 1993-08-17 Miles Inc. Platelets concentrate with low white blood cells content
US5147776A (en) 1990-02-26 1992-09-15 University Of Iowa Research Foundation Use of 2,5-anhydromannitol for control of pH during blood storage
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5516629A (en) 1990-04-16 1996-05-14 Cryopharm Corporation Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins
US5798238A (en) 1990-04-16 1998-08-25 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer
US5587490A (en) 1990-04-16 1996-12-24 Credit Managers Association Of California Method of inactivation of viral and bacterial blood contaminants
US5342752A (en) 1990-04-16 1994-08-30 Cryopharm Corporation Method of inactivation of viral blood contaminants using acridine deriatives
US5955256A (en) 1990-04-16 1999-09-21 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US6077659A (en) 1990-05-15 2000-06-20 New York Blood Center, Inc. Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light
US5120649A (en) 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5658722A (en) 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US5232844A (en) 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
DE69126861T2 (de) 1990-11-07 1998-02-26 Baxter Int Lösung zur aufbewahrung roter blutzellen
CA2071835A1 (en) 1990-11-07 1992-05-08 Gerald A. Grode Blood platelet storage medium
AU646533B2 (en) 1990-12-20 1994-02-24 Baxter International Inc. Systems for eradicating contaminants in fluids
US5376524A (en) 1991-04-01 1994-12-27 Thomas Jefferson University Platelet storage medium containing acetate and phosphate
US5569579A (en) 1991-04-01 1996-10-29 Thomas Jefferson University Synthetic-based platelet storage media
FR2715303A1 (fr) 1991-04-02 1995-07-28 Berque Jean Utilisation du FAD et/ou du NAD comme médicaments.
FR2674753B1 (fr) 1991-04-02 1995-03-10 Jean Berque Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables.
WO1992019355A1 (en) 1991-05-08 1992-11-12 Baxter International Inc. Methods for processing red blood cell products for long term storage free of microorganisms
NZ244270A (en) 1991-09-13 1995-07-26 Eisai Co Ltd Injectable composition comprising riboflavin
US5474891A (en) 1991-10-30 1995-12-12 Thomas Jefferson University Plasma-based platelet concentrate preparations with additive
US5344752A (en) 1991-10-30 1994-09-06 Thomas Jefferson University Plasma-based platelet concentrate preparations
US5234808A (en) 1991-10-30 1993-08-10 Thomas Jefferson University Acetate addition to platelets stored in plasma
US5247178A (en) 1991-12-12 1993-09-21 Fusion Systems Corporation Method and apparatus for treating fluids by focusing reflected light on a thin fluid layer
US5459030A (en) 1992-03-02 1995-10-17 Steritech, Inc. Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
WO1996014740A1 (en) 1992-03-02 1996-05-23 Cerus Corporation Synthetic media for blood components
US5288605A (en) 1992-03-02 1994-02-22 Steritech, Inc. Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
US5618662A (en) 1992-03-02 1997-04-08 Cerus Corporation Intravenous administration of psoralen
SE9201413L (sv) 1992-04-30 1993-10-31 Stiftelsen Foer Medicinsk Tekn Beredning och sätt för aferesframställning av trombocytkoncentrat med väsentligt förlängd hållbarhet
US5378601A (en) 1992-07-24 1995-01-03 Montefiore Medical Center Method of preserving platelets with apyrase and an antioxidant
WO1994003054A1 (en) 1992-08-07 1994-02-17 Steritech, Inc. Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
TW262386B (enExample) 1992-09-30 1995-11-11 Senju Pharma Co
US5358844A (en) 1993-02-18 1994-10-25 Brigham And Women's Hospital, Inc. Preservation of blood platelets
US5871900A (en) 1993-06-28 1999-02-16 Cerus Corporation Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens
US5593823A (en) 1993-06-28 1997-01-14 Cerus Corporation Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens
US5712085A (en) 1993-06-28 1998-01-27 Cerus Corporation 5'-(4-amino-2-oxa)butye-4,4', 8-trinethylpsoralen in synthetic medium
US6004741A (en) 1993-06-28 1999-12-21 Cerus Corporation Method for the photoactivation of 4' and 5' primary aminoalkyl psoralens in platelet preparations
DE69534151T2 (de) 1994-02-22 2006-01-12 Nippon Telegraph And Telephone Corp. Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung
FR2718353B3 (fr) 1994-04-11 1996-06-28 Jean Berque Compositions pharmaceutiques à base de produits biologiques atoxiques destinées à la protection locale des muqueuses génitales et rectales.
US5709992A (en) 1994-08-17 1998-01-20 Rubinstein; Alan I. Method for disinfecting red blood cells
US5622867A (en) 1994-10-19 1997-04-22 Lifecell Corporation Prolonged preservation of blood platelets
US5919614A (en) 1994-10-19 1999-07-06 Lifecell Corporation Composition comprising three platelet lesion inhibitors for platelet storage
EP0793414A2 (en) 1994-11-14 1997-09-10 Pall Corporation Long-term blood component storage system and method
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
JP4041171B2 (ja) * 1994-12-14 2008-01-30 日本赤十字社 血小板保存液
US5605934A (en) 1995-03-23 1997-02-25 Baxter International Inc. Method of manufacturing and storing solutions
US5624794A (en) 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
US5656154A (en) 1995-06-07 1997-08-12 Organ, Inc. Method and apparatus for separating a fluid into components and for washing a material
WO1997000679A1 (en) 1995-06-23 1997-01-09 Medichem Research, Inc. Biflavanoids and derivatives thereof as antiviral agents
JP2930908B2 (ja) 1995-07-19 1999-08-09 川澄化学工業株式会社 血小板保存液
US5736313A (en) 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
US5834198A (en) 1996-03-21 1998-11-10 Boehringer Mamnnheim Gmbh Selective photoinducted flavin-dependent cleavage of RNA at G-U base pairs and kits therefor
US6060233A (en) 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US5783093A (en) 1997-01-02 1998-07-21 Haemonetics Corporation Blood cell concentrates using a single solution for anticoagulation and preservation
WO1998031219A1 (en) * 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US6605699B1 (en) * 1997-01-21 2003-08-12 Human Genome Sciences, Inc. Galectin-11 polypeptides
US5789151A (en) 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
US6063624A (en) 1997-06-09 2000-05-16 Baxter International Inc. Platelet suspensions and methods for resuspending platelets
US5922256A (en) * 1997-06-26 1999-07-13 Textron Automotive Company, Inc. Molding method for making plastic foam-backed shells
US5955257A (en) 1997-10-21 1999-09-21 Regents Of The University Of Minnesota Infusible grade short-term cell storage medium for mononuclear cells
US7094378B1 (en) * 2000-06-15 2006-08-22 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US6268120B1 (en) * 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants

Also Published As

Publication number Publication date
WO2002043485A1 (en) 2002-06-06
JP4473508B2 (ja) 2010-06-02
US20040023201A9 (en) 2004-02-05
DE60118604T2 (de) 2006-12-14
JP2004514680A (ja) 2004-05-20
EP1345491B1 (en) 2006-04-05
DE60118604D1 (de) 2006-05-18
AU2002225687A1 (en) 2002-06-11
US20030186213A1 (en) 2003-10-02
EP1345491A1 (en) 2003-09-24
ATE322162T1 (de) 2006-04-15
US6548241B1 (en) 2003-04-15
CA2397862A1 (en) 2002-06-06

Similar Documents

Publication Publication Date Title
CA2397862C (en) Storage solution containing photosensitizer for inactivation of biological contaminants
CA2304696C (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
EP1047458B1 (en) Method for inactivation of microorganisms using photosensitizers
US7094378B1 (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
JP2004500316A5 (enExample)
WO2001094349A1 (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
US20030215784A1 (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
EP1404379A2 (en) Viral inactivation process using antioxidant
AU770614B2 (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
CA2585179C (en) Method and apparatus for inactivation of biological contaminants using photosensitizers
CZ20001406A3 (cs) Řešení se týká léčiva k léčení získaného hyperkoagulovatelného stavu nebo získané nedostatečnosti proteinu C. Týká se lidských pacientů se získaným hyperkoagulovatelným stavem nebo získanou nedostatečností proteinu C souvisejícím se sepsí, purpura fulminans, meningokokální sepsí, transplantací kostní dřeně nebo dalšími transplantacemi, těžkými popáleninami, těhotenstvím, těžkými chirurgickými zákroky, těžkým traumatem nebo ARDS, které zahrnuje podávání aktivovaného proteinu C, který představuje vysoce selektivní terapeutické činidlo s nízkým potenciálem způsobení komplikací představujících krvácením.
MXPA00002800A (en) Method and apparatus for inactivation of biological contaminants using photosensitizers

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20211122