JP2004513626A5 - - Google Patents
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- Publication number
- JP2004513626A5 JP2004513626A5 JP2002526886A JP2002526886A JP2004513626A5 JP 2004513626 A5 JP2004513626 A5 JP 2004513626A5 JP 2002526886 A JP2002526886 A JP 2002526886A JP 2002526886 A JP2002526886 A JP 2002526886A JP 2004513626 A5 JP2004513626 A5 JP 2004513626A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- clusterin
- disease
- antisense oligonucleotide
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 239000000074 antisense oligonucleotide Substances 0.000 claims 7
- 238000012230 antisense oligonucleotides Methods 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 102000003780 Clusterin Human genes 0.000 claims 6
- 108090000197 Clusterin Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 238000001246 colloidal dispersion Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/659,791 US6383808B1 (en) | 2000-09-11 | 2000-09-11 | Antisense inhibition of clusterin expression |
| PCT/US2001/028235 WO2002022635A1 (en) | 2000-09-11 | 2001-09-10 | Antisense modulation of clusterin expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009191924A Division JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513626A JP2004513626A (ja) | 2004-05-13 |
| JP2004513626A5 true JP2004513626A5 (https=) | 2005-03-17 |
| JP4397585B2 JP4397585B2 (ja) | 2010-01-13 |
Family
ID=24646855
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526886A Expired - Fee Related JP4397585B2 (ja) | 2000-09-11 | 2001-09-10 | クラスタリン発現のアンチセンスモジュレーション |
| JP2009191924A Pending JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
| JP2013156811A Pending JP2014027936A (ja) | 2000-09-11 | 2013-07-29 | クラスタリン発現のアンチセンスモジュレーション |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009191924A Pending JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
| JP2013156811A Pending JP2014027936A (ja) | 2000-09-11 | 2013-07-29 | クラスタリン発現のアンチセンスモジュレーション |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6383808B1 (https=) |
| EP (1) | EP1325019B1 (https=) |
| JP (3) | JP4397585B2 (https=) |
| AT (1) | ATE496127T1 (https=) |
| AU (1) | AU2001290706A1 (https=) |
| DE (1) | DE60143901D1 (https=) |
| WO (1) | WO2002022635A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040121973A1 (en) * | 2002-02-05 | 2004-06-24 | Monia Brett P | Antisense modulation of protein phosphatase 2 Catalytic subunit alpha expression |
| US6444650B1 (en) * | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
| KR100768109B1 (ko) * | 1999-02-26 | 2007-10-17 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 테스토스테론이 억제된 전립선 메시지-2의 안티센스치료방법 |
| US6900187B2 (en) * | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7407943B2 (en) * | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| AU2003237616B2 (en) * | 2002-01-17 | 2007-07-05 | The University Of British Columbia | Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same |
| US20040102401A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of jagged 1 expression |
| EP1520021A2 (en) * | 2002-07-01 | 2005-04-06 | Pharmacia Corporation | Antisense modulation of lrh1 expression |
| JP4717633B2 (ja) * | 2002-08-21 | 2011-07-06 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 癌関連タンパク質を標的とするRNAiプローブ |
| NZ538288A (en) * | 2002-08-21 | 2008-04-30 | Univ British Columbia | Treatment of melanoma by reduction in clusterin levels |
| US20040224914A1 (en) * | 2003-04-18 | 2004-11-11 | The University Of British Columbia | Method for treatment of angiogenic disorders |
| WO2004092378A2 (en) * | 2003-04-18 | 2004-10-28 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| US7825235B2 (en) | 2003-08-18 | 2010-11-02 | Isis Pharmaceuticals, Inc. | Modulation of diacylglycerol acyltransferase 2 expression |
| EP1708730A2 (en) * | 2004-01-20 | 2006-10-11 | DeveloGen Aktiengesellschaft | Use of a dg147 protein product for preventing and treating metabolic disorders |
| US20050164271A1 (en) * | 2004-01-20 | 2005-07-28 | Sanjay Bhanot | Modulation of glucocorticoid receptor expression |
| WO2005094899A1 (en) | 2004-04-02 | 2005-10-13 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| US20060205669A1 (en) * | 2004-09-16 | 2006-09-14 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| ITBZ20040048A1 (it) * | 2004-10-06 | 2005-01-06 | Genprofiler | Metodo per l'identificazione della trasformazione neoplastica, con particolare riferimento al cancro prostatico |
| DK1814595T3 (da) * | 2004-11-23 | 2014-03-31 | Univ British Columbia | Behandling af cancer med en kombination af et middel, som forstyrrer EGF-signalvejen og et oligonucleotid, som reducerer clusterinniveauerne |
| WO2006063132A2 (en) | 2004-12-06 | 2006-06-15 | The Regents Of The University Of California | Methods for improving the structure and function of arterioles |
| KR20080007491A (ko) * | 2005-04-29 | 2008-01-21 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 염증성 반응을 특징으로 하는 병리를 치료하기 위한 펩티드및 펩티드 모방체 |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| AU2006291990B2 (en) * | 2005-09-13 | 2012-05-31 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
| CN101679979A (zh) | 2007-03-24 | 2010-03-24 | 基酶有限公司 | 施用与人载脂蛋白b互补的反义寡核苷酸 |
| US8557767B2 (en) | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| AU2008296478B9 (en) | 2007-08-28 | 2015-03-19 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| US8916531B2 (en) | 2007-11-20 | 2014-12-23 | Isis Pharmaceuticals, Inc. | Modulation of CD40 expression |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| CN102666585B (zh) | 2009-11-24 | 2015-02-18 | 阿莱斯亚生物疗法股份有限公司 | 抗簇蛋白抗体和抗原结合片段及其减小肿瘤体积的用途 |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| JP2014506791A (ja) | 2011-02-03 | 2014-03-20 | マーナ セラピューティクス インコーポレイテッド | miR−34の合成模倣体 |
| CN103459598B (zh) | 2011-02-03 | 2016-08-10 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| WO2012123823A1 (en) | 2011-03-15 | 2012-09-20 | The University Of British Columbia | Combination of anti-clusterin oligonucleotide with hsp90 inhibitor for the treatment of prostate cancer |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| HK1200484A1 (zh) | 2011-09-14 | 2015-08-07 | Translate Bio Ma, Inc. | 多聚寡核苷酸化合物 |
| WO2013123588A1 (en) | 2012-02-22 | 2013-08-29 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | キラル制御 |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| EP2895200B1 (en) | 2012-09-14 | 2019-11-06 | Translate Bio MA, Inc. | Multimeric oligonucleotide compounds |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| MX383117B (es) | 2014-07-31 | 2025-03-13 | Anji Pharmaceuticals Inc | Péptidos miméticos de la apoe y mayor potencia para depurar el colesterol en plasma. |
| WO2016130943A1 (en) | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| EP3256592A4 (en) * | 2015-02-13 | 2018-09-12 | Translate Bio Ma, Inc. | Compositions and methods for modulating rna |
| CN107709555A (zh) * | 2015-05-15 | 2018-02-16 | 达尔马科恩有限公司 | 用于Cas9介导的基因编辑的合成的单向导RNA |
| CA2991894A1 (en) | 2015-07-10 | 2017-01-19 | Ionis Pharmaceuticals, Inc. | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| FR3069156B1 (fr) * | 2017-07-21 | 2019-08-09 | Universite de Bordeaux | Clusterine pour son utilisation dans le traitement des micro-angiopathies thrombotiques |
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| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
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| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
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| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
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| CA2092002A1 (en) | 1990-09-20 | 1992-03-21 | Mark Matteucci | Modified internucleoside linkages |
| FR2692265B1 (fr) | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | Composes biologiquement actifs de type phosphotriesters. |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| FR2705099B1 (fr) | 1993-05-12 | 1995-08-04 | Centre Nat Rech Scient | Oligonucléotides phosphorothioates triesters et procédé de préparation. |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| AUPM301293A0 (en) | 1993-12-17 | 1994-01-20 | University Of Melbourne, The | Methods and reagents for sperm analysis |
| US5695995A (en) * | 1994-05-06 | 1997-12-09 | Fred Hutchinson Cancer Research Center | Neurogenic differentiation (neurod) genes |
| US5786213A (en) * | 1996-04-18 | 1998-07-28 | Board Of Regents, The University Of Texas System | Inhibition of endogenous gastrin expression for treatment of colorectal cancer |
| US5739310A (en) * | 1996-04-23 | 1998-04-14 | Fred Hutchinson Cancer Research Center | Ribosomes as vectors for RNA |
| US5945290A (en) * | 1998-09-18 | 1999-08-31 | Isis Pharmaceuticals, Inc. | Antisense modulation of RhoA expression |
| US5959097A (en) * | 1998-11-20 | 1999-09-28 | Isis Pharmaceuticals, Inc. | Antisense modulation of MEK2 expression |
| US6464975B2 (en) * | 1998-12-11 | 2002-10-15 | The Research Foundation Of State University Of New York | Compositions and methods for altering cell migration |
| US5948680A (en) * | 1998-12-17 | 1999-09-07 | Isis Pharmaceuticals Inc. | Antisense inhibition of Elk-1 expression |
| US5958773A (en) * | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| KR100768109B1 (ko) | 1999-02-26 | 2007-10-17 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 테스토스테론이 억제된 전립선 메시지-2의 안티센스치료방법 |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
-
2000
- 2000-09-11 US US09/659,791 patent/US6383808B1/en not_active Expired - Lifetime
-
2001
- 2001-09-10 JP JP2002526886A patent/JP4397585B2/ja not_active Expired - Fee Related
- 2001-09-10 AU AU2001290706A patent/AU2001290706A1/en not_active Abandoned
- 2001-09-10 AT AT01970728T patent/ATE496127T1/de not_active IP Right Cessation
- 2001-09-10 US US10/380,124 patent/US20040053874A1/en not_active Abandoned
- 2001-09-10 WO PCT/US2001/028235 patent/WO2002022635A1/en not_active Ceased
- 2001-09-10 EP EP01970728A patent/EP1325019B1/en not_active Expired - Lifetime
- 2001-09-10 DE DE60143901T patent/DE60143901D1/de not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009191924A patent/JP2010043086A/ja active Pending
-
2013
- 2013-07-29 JP JP2013156811A patent/JP2014027936A/ja active Pending
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