JP2004512810A5 - - Google Patents

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Publication number
JP2004512810A5
JP2004512810A5 JP2001520859A JP2001520859A JP2004512810A5 JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5 JP 2001520859 A JP2001520859 A JP 2001520859A JP 2001520859 A JP2001520859 A JP 2001520859A JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001520859A
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English (en)
Japanese (ja)
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JP2004512810A (ja
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Publication date
Priority claimed from US09/474,432 external-priority patent/US6528640B1/en
Priority claimed from US09/476,387 external-priority patent/US6617438B1/en
Application filed filed Critical
Priority claimed from PCT/US2000/023998 external-priority patent/WO2001016312A2/en
Publication of JP2004512810A publication Critical patent/JP2004512810A/ja
Publication of JP2004512810A5 publication Critical patent/JP2004512810A5/ja
Pending legal-status Critical Current

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JP2001520859A 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤 Pending JP2004512810A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US15171399P 1999-08-31 1999-08-31
US40664399A 1999-09-27 1999-09-27
US15646799P 1999-09-27 1999-09-27
US15623699P 1999-09-27 1999-09-27
US43643099A 1999-11-08 1999-11-08
US16910099P 1999-12-06 1999-12-06
US17361299P 1999-12-29 1999-12-29
US09/474,432 US6528640B1 (en) 1997-11-05 1999-12-29 Synthetic ribonucleic acids with RNAse activity
US09/476,387 US6617438B1 (en) 1997-11-05 1999-12-30 Oligoribonucleotides with enzymatic activity
US49882400A 2000-02-04 2000-02-04
US53102500A 2000-03-20 2000-03-20
US19776900P 2000-04-14 2000-04-14
US57822300A 2000-05-23 2000-05-23
US63638500A 2000-08-09 2000-08-09
PCT/US2000/023998 WO2001016312A2 (en) 1999-08-31 2000-08-30 Nucleic acid based modulators of gene expression

Publications (2)

Publication Number Publication Date
JP2004512810A JP2004512810A (ja) 2004-04-30
JP2004512810A5 true JP2004512810A5 (enExample) 2005-01-06

Family

ID=27585071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001520859A Pending JP2004512810A (ja) 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤

Country Status (4)

Country Link
EP (1) EP1212416A2 (enExample)
JP (1) JP2004512810A (enExample)
CA (1) CA2403243A1 (enExample)
WO (1) WO2001016312A2 (enExample)

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US6617438B1 (en) * 1997-11-05 2003-09-09 Sirna Therapeutics, Inc. Oligoribonucleotides with enzymatic activity
US6482932B1 (en) * 1997-11-05 2002-11-19 Ribozyme Pharmaceuticals, Incorporated Nucleoside triphosphates and their incorporation into oligonucleotides
US20020055479A1 (en) * 2000-01-18 2002-05-09 Cowsert Lex M. Antisense modulation of PTP1B expression
US7179796B2 (en) 2000-01-18 2007-02-20 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
US7125660B2 (en) 2000-09-13 2006-10-24 Archemix Corp. Nucleic acid sensor molecules and methods of using same
WO2002097114A2 (en) * 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2003070983A1 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003034985A2 (en) * 2001-10-22 2003-05-01 University Of Rochester Telomerase interference
AU2003215161A1 (en) * 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF TELOMERASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
CA2484744C (en) * 2002-05-17 2015-09-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Molecular identification of aspergillus species
US7507808B2 (en) 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
US7605249B2 (en) 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
FR2848573B1 (fr) * 2002-12-13 2005-04-08 Exonhit Therapeutics Sa Compositions et methodes pour la detection et le traitement de pathologies neurodegeneratives
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
US7803781B2 (en) * 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
WO2004083432A1 (en) 2003-03-21 2004-09-30 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
JP4564052B2 (ja) * 2004-04-08 2010-10-20 サンガモ バイオサイエンシズ インコーポレイテッド 心筋収縮能調節用の方法及び組成物
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
EP1833966A2 (en) * 2004-12-14 2007-09-19 National Institute of Immunology Dnazymes for inhibition of japanese encephalitis virus replication
CA2600886A1 (en) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
US9133517B2 (en) 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
LT2056845T (lt) 2006-08-08 2017-11-27 Rheinische Friedrich-Wilhelms-Universität Bonn 5` fosfato oligonukleotidų struktūra ir panaudojimas
US9375440B2 (en) 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
PT2203173E (pt) 2007-10-26 2016-03-15 Academisch Ziekenhuis Leiden Resumo
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
WO2009141146A1 (en) 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
ES2593836T3 (es) 2009-04-24 2016-12-13 Biomarin Technologies B.V. Oligonucleótido que comprende una inosina para tratar la DMD
EP2512491B1 (en) 2009-10-16 2017-10-11 Glaxo Group Limited Hbv antisense inhibitors
US9243246B2 (en) 2010-08-24 2016-01-26 Sirna Therapeutics, Inc. Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
EP3327125B1 (en) 2010-10-29 2020-08-05 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
RU2013126706A (ru) 2010-11-15 2014-12-27 Рамот Ат Тель-Авив Юниверсити Лтд. Дипептидные аналоги для лечения состояний, ассоциированных с образованием амилоидных фибрилл
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
KR101839177B1 (ko) 2011-04-13 2018-03-15 아이오니스 파마수티컬즈, 인코포레이티드 Ptpib 발현의 안티센스 조절
CR20190207A (es) 2011-04-21 2019-06-26 Ionis Pharmaceuticals Inc MODULACIÓN DE LA EXPRESIÓN DEL VIRUS DE LA HEPATITIS B (VHB) (Divisional 2013-0551)
CA2862628C (en) 2012-01-27 2021-08-24 Prosensa Technologies B.V. Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
BR112015001769A2 (pt) * 2012-07-27 2017-08-22 Bial Portela & Ca Sa Processo para a síntese de compostos de ureia substituída
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
GB201408623D0 (en) * 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
DE102015113038B3 (de) * 2015-07-13 2017-01-19 Simone Kann Oligonucleotide und deren Verwendung
WO2017048620A1 (en) * 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
WO2019079195A1 (en) * 2017-10-16 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education GENETICALLY MODIFIED MESENCHYMAL STEM CELLS FOR USE IN CARDIOVASCULAR PROSTHESES
GB201817990D0 (en) 2018-11-02 2018-12-19 Univ Of Essex Enterprise Limited Enzymatic nucleic acid molecules
MX2023009429A (es) * 2021-02-11 2023-09-27 Ionis Pharmaceuticals Inc Compuestos y metodos para reducir la expresion de pln.
WO2025007063A1 (en) * 2023-06-30 2025-01-02 Avidity Biosciences, Inc. Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates

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EP1108724B1 (en) * 1996-01-16 2007-09-19 Sirna Therpeutics, Inc. Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
WO1997037013A1 (en) * 1996-04-02 1997-10-09 Commonwealth Scientific And Industrial Research Organisation Asymmetric hammerhead ribozymes
EP2275546A3 (en) * 1997-04-29 2013-06-05 The Scripps Research Institute Enzymatic DNA molecules

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