JP2004512497A5 - - Google Patents
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- Publication number
- JP2004512497A5 JP2004512497A5 JP2002506110A JP2002506110A JP2004512497A5 JP 2004512497 A5 JP2004512497 A5 JP 2004512497A5 JP 2002506110 A JP2002506110 A JP 2002506110A JP 2002506110 A JP2002506110 A JP 2002506110A JP 2004512497 A5 JP2004512497 A5 JP 2004512497A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- particles
- agent
- ligand
- colloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 179
- 239000002245 particle Substances 0.000 description 105
- 239000011324 bead Substances 0.000 description 54
- 230000011664 signaling Effects 0.000 description 51
- 239000003795 chemical substances by application Substances 0.000 description 49
- 239000003446 ligand Substances 0.000 description 49
- 239000000084 colloidal system Substances 0.000 description 43
- 102000004169 proteins and genes Human genes 0.000 description 43
- 108090000623 proteins and genes Proteins 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 38
- 241000894007 species Species 0.000 description 36
- 239000002184 metal Substances 0.000 description 35
- 229910052751 metal Inorganic materials 0.000 description 35
- 239000000203 mixture Substances 0.000 description 31
- 239000002094 self assembled monolayer Substances 0.000 description 26
- 239000013545 self-assembled monolayer Substances 0.000 description 26
- 239000013522 chelant Substances 0.000 description 25
- 102000004190 Enzymes Human genes 0.000 description 24
- 108090000790 Enzymes Proteins 0.000 description 24
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 17
- 239000003124 biologic agent Substances 0.000 description 16
- 239000013043 chemical agent Substances 0.000 description 16
- 229940079593 drug Drugs 0.000 description 16
- 239000003814 drug Substances 0.000 description 16
- 102000005962 receptors Human genes 0.000 description 16
- 229940000406 drug candidate Drugs 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 14
- 239000007787 solid Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 239000000412 dendrimer Substances 0.000 description 11
- 229920000736 dendritic polymer Polymers 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 230000003993 interaction Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 230000003213 activating effect Effects 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 239000002356 single layer Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 108010001857 Cell Surface Receptors Proteins 0.000 description 3
- 102000000844 Cell Surface Receptors Human genes 0.000 description 3
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 3
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000006854 communication Effects 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 102000005720 Glutathione transferase Human genes 0.000 description 2
- 108010070675 Glutathione transferase Proteins 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 230000009141 biological interaction Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical group OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 238000001338 self-assembly Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- -1 antibody Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002052 molecular layer Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 230000010807 negative regulation of binding Effects 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 238000004832 voltammetry Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60277800A | 2000-06-23 | 2000-06-23 | |
| PCT/US2001/020168 WO2002001228A2 (en) | 2000-06-23 | 2001-06-25 | Interaction of colloid-immobilized species with species on non-colloidal structures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004512497A JP2004512497A (ja) | 2004-04-22 |
| JP2004512497A5 true JP2004512497A5 (enExample) | 2008-08-21 |
Family
ID=24412766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002506110A Pending JP2004512497A (ja) | 2000-06-23 | 2001-06-25 | コロイドが固定された種と非コロイド構造上の種との相互作用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1309858A2 (enExample) |
| JP (1) | JP2004512497A (enExample) |
| AU (1) | AU7014001A (enExample) |
| CA (1) | CA2413932A1 (enExample) |
| WO (1) | WO2002001228A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002216614A1 (en) | 2000-10-03 | 2002-04-15 | Minerva Biotechnologies Corporation | Electronic detection of interaction based on the interruption of flow |
| DE10109777A1 (de) * | 2001-03-01 | 2002-09-19 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren |
| DE10214719A1 (de) * | 2002-04-03 | 2003-11-20 | Infineon Technologies Ag | Sensor zur qualitativen und quantitativen Bestimmung von (bio)organischen Oligomeren und Polymeren, Analyseverfahren hierzu sowie Verfahren zur Herstellung des Sensors |
| GB2391230A (en) * | 2002-07-26 | 2004-02-04 | Smartbead Technologies Ltd | Multiparameter assays using coded supports |
| AU2003284278A1 (en) | 2002-10-18 | 2004-05-04 | The University Of Iowa Research Foundation | Magnetically modified electrodes containing at least one catalyst component that mediates a subatomic particle transfer process |
| KR100859403B1 (ko) | 2003-03-14 | 2008-09-22 | 자이단호진 기타큐슈산교가쿠쥬쓰스이신키코 | 생체 물질 고정화 칩 및 그의 용도 |
| WO2005052590A1 (en) | 2003-11-29 | 2005-06-09 | Proteogen, Inc. | High-throughput screening method for integrin antagonist and new peptide screened therefrom |
| JP4941551B2 (ja) * | 2007-03-30 | 2012-05-30 | 富士通株式会社 | 有機物質検出デバイス及びその製造方法 |
| SE532583C2 (sv) * | 2008-04-24 | 2010-02-23 | Svanova Biotech Ab | Guldinnehållande molekylaggregat för detektering av kemiska- och biokemiska specier |
| WO2018111941A1 (en) * | 2016-12-12 | 2018-06-21 | 13.8, Inc. | Compositions of high affinity reagents and methods of use thereof |
| EP3460472B1 (en) * | 2017-09-22 | 2024-09-18 | Nokia Technologies Oy | Functionalised particles |
| EP3593708B1 (en) | 2018-07-13 | 2024-08-28 | Nokia Technologies Oy | Artificial skin |
| CN110078829B (zh) * | 2019-04-29 | 2021-01-15 | 大连理工大学 | 一种基于乙烯基砜表面反应的组氨酸标签蛋白定点共价固定方法 |
| WO2021210189A1 (ja) * | 2020-04-18 | 2021-10-21 | 有限会社マイテック | 病原体量子結晶固相化基板およびそれを用いる病原体の量子結晶固相化蛍光計数法 |
| US11609229B2 (en) * | 2020-04-30 | 2023-03-21 | Mytech Co. Ltd. | Fluorescence counting system for quantifying viruses or antibodies on an immobilized metal substrate by using an antigen-antibody reaction |
| CA3183682A1 (en) | 2020-06-26 | 2021-12-30 | Minerva Biotechnologies Corporation | Anti-nme antibody and method of treating cancer or cancer metastasis |
| CA3248038A1 (en) | 2022-04-12 | 2023-10-19 | Minerva Biotechnologies Corporation | ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0750112B2 (ja) * | 1988-04-26 | 1995-05-31 | 日本電信電話株式会社 | レーザ磁気免疫測定方法を実施するための検体調整方法 |
| IL85137A (en) * | 1987-01-21 | 1992-02-16 | Ares Serono Res & Dev Ltd | Method of assaying for a ligand using surface plasmon resonance effect |
| US5369036A (en) * | 1992-07-02 | 1994-11-29 | Becton, Dickinson And Company | Enhancement of signal in immunoassays using microparticles which contain different detectable substances |
| JPH1132764A (ja) * | 1997-07-14 | 1999-02-09 | Yakult Honsha Co Ltd | ビフィドバクテリウム・ブレーベ用モノクローナル抗体 |
-
2001
- 2001-06-25 JP JP2002506110A patent/JP2004512497A/ja active Pending
- 2001-06-25 EP EP01948690A patent/EP1309858A2/en not_active Withdrawn
- 2001-06-25 WO PCT/US2001/020168 patent/WO2002001228A2/en not_active Ceased
- 2001-06-25 CA CA002413932A patent/CA2413932A1/en not_active Abandoned
- 2001-06-25 AU AU7014001A patent/AU7014001A/xx active Pending
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