JP2004510775A5 - - Google Patents
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- Publication number
- JP2004510775A5 JP2004510775A5 JP2002532446A JP2002532446A JP2004510775A5 JP 2004510775 A5 JP2004510775 A5 JP 2004510775A5 JP 2002532446 A JP2002532446 A JP 2002532446A JP 2002532446 A JP2002532446 A JP 2002532446A JP 2004510775 A5 JP2004510775 A5 JP 2004510775A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- arrhythmia
- oxobutyl
- benzonitrile
- oxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 14
- 206010003119 arrhythmia Diseases 0.000 claims description 10
- 230000006793 arrhythmia Effects 0.000 claims description 10
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- -1 3,3-dimethyl-2-oxobutyl Chemical group 0.000 claims description 2
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims description 2
- AEDCSEJQZCCQMJ-UHFFFAOYSA-N O.C1(=CC=CC=C1)S(=O)(=O)O.CC(C(CN1CC2CN(CC(C1)O2)CCCNC2=CC=C(C#N)C=C2)=O)(C)C Chemical compound O.C1(=CC=CC=C1)S(=O)(=O)O.CC(C(CN1CC2CN(CC(C1)O2)CCCNC2=CC=C(C#N)C=C2)=O)(C)C AEDCSEJQZCCQMJ-UHFFFAOYSA-N 0.000 claims description 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000001746 atrial effect Effects 0.000 claims description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 2
- 229940092714 benzenesulfonic acid Drugs 0.000 claims description 2
- WQQQISVKJCGCPL-UHFFFAOYSA-N benzenesulfonic acid;4-[3-[3-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]propylamino]benzonitrile Chemical compound OS(=O)(=O)C1=CC=CC=C1.C1C(O2)CN(CC(=O)C(C)(C)C)CC2CN1CCCNC1=CC=C(C#N)C=C1 WQQQISVKJCGCPL-UHFFFAOYSA-N 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PH12000002701 | 2000-10-02 | ||
| PCT/SE2000/001994 WO2001028992A2 (en) | 1999-10-18 | 2000-10-13 | New oxabispidine compounds useful in the treatment of cardiac arrhythmias |
| PCT/SE2001/002129 WO2002028863A1 (en) | 2000-10-02 | 2001-10-01 | New oxabispidine compound useful in the treatment of cardiac arrhythmias |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004510775A JP2004510775A (ja) | 2004-04-08 |
| JP2004510775A5 true JP2004510775A5 (cg-RX-API-DMAC7.html) | 2005-12-15 |
Family
ID=52573779
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532446A Pending JP2004510775A (ja) | 2000-10-02 | 2001-10-01 | 心不整脈の治療に有用な新規なオキサビスピジン化合物 |
| JP2002532447A Expired - Fee Related JP4248873B2 (ja) | 2000-10-02 | 2001-10-01 | オキサビスピジンの新規製造法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532447A Expired - Fee Related JP4248873B2 (ja) | 2000-10-02 | 2001-10-01 | オキサビスピジンの新規製造法 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US6936712B1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1900741A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2004510775A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20030032060A (cg-RX-API-DMAC7.html) |
| CN (3) | CN1243754C (cg-RX-API-DMAC7.html) |
| AR (1) | AR030756A1 (cg-RX-API-DMAC7.html) |
| AU (3) | AU9250401A (cg-RX-API-DMAC7.html) |
| BR (2) | BR0114366A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2421776A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ294217B6 (cg-RX-API-DMAC7.html) |
| EE (1) | EE200300131A (cg-RX-API-DMAC7.html) |
| HU (1) | HUP0302288A3 (cg-RX-API-DMAC7.html) |
| IL (3) | IL154803A0 (cg-RX-API-DMAC7.html) |
| IS (1) | IS6744A (cg-RX-API-DMAC7.html) |
| MX (2) | MXPA03002759A (cg-RX-API-DMAC7.html) |
| NO (2) | NO20031413L (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ524573A (cg-RX-API-DMAC7.html) |
| PL (1) | PL364047A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2003107668A (cg-RX-API-DMAC7.html) |
| SK (1) | SK3862003A3 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2002028864A1 (cg-RX-API-DMAC7.html) |
| ZA (2) | ZA200301757B (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
| SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| CN101243093A (zh) | 2005-06-13 | 2008-08-13 | 阿斯利康(瑞典)有限公司 | 用于治疗心律不齐的新型氧杂双哌啶化合物 |
| WO2006137772A1 (en) * | 2005-06-20 | 2006-12-28 | Astrazeneca Ab | New physical form of n,n´- disubstituted oxabispidines |
| WO2006137770A1 (en) * | 2005-06-20 | 2006-12-28 | Astrazeneca Ab | Process for the preparation of n,n´- disubstituted oxabispidines |
| AR054391A1 (es) * | 2005-06-20 | 2007-06-20 | Astrazeneca Ab | Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos |
| BRPI0611841A2 (pt) * | 2005-06-20 | 2016-08-30 | Astrazeneca Ab | processos para isolar um sal, para preparar um sal, e para a preparação de um composto |
| CN103319423B (zh) * | 2013-06-28 | 2015-10-28 | 江苏师范大学 | 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法 |
| KR20150082070A (ko) | 2014-01-06 | 2015-07-15 | (주)신비넷 | 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법 |
| EP3059229A1 (en) | 2015-02-17 | 2016-08-24 | Evonik Degussa GmbH | Method for the epoxidation of an olefin with hydrogen peroxide |
| CN115054728B (zh) * | 2022-07-18 | 2023-11-07 | 中国科学院大学宁波华美医院 | 一种仿生骨组织工程支架材料及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3503939A (en) * | 1967-03-29 | 1970-03-31 | Du Pont | Polyamides from heterocyclic diamines |
| DE2428792A1 (de) * | 1974-06-14 | 1976-01-02 | Knoll Ag | Neue antiarrhythmika |
| DE3112055A1 (de) * | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
| DE3234697A1 (de) * | 1982-09-18 | 1984-03-22 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue diazabicyclo-(3,3,1)-nonane |
| DE3732094A1 (de) * | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| DE3902357A1 (de) | 1989-01-27 | 1990-08-02 | Hoechst Ag | Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen |
| US5140033A (en) * | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
| US5110933A (en) * | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
| US5831099A (en) | 1995-03-10 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Army | Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same |
| US5939568A (en) | 1997-01-31 | 1999-08-17 | The Scripps Research Institute | Accelerated catalysis of olefinic epoxidations |
| SE9704709D0 (sv) | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| HK1042091A1 (zh) * | 1999-04-09 | 2002-08-02 | 阿斯特拉曾尼卡有限公司 | 金剛烷衍生物 |
| AUPQ274199A0 (en) | 1999-09-09 | 1999-09-30 | Ericsson Australia Pty Ltd | Information transmission rate control across a core network |
| SE9903759D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
-
2001
- 2001-09-18 AR ARP010104406A patent/AR030756A1/es unknown
- 2001-10-01 AU AU9250401A patent/AU9250401A/xx active Pending
- 2001-10-01 RU RU2003107668/04A patent/RU2003107668A/ru not_active Application Discontinuation
- 2001-10-01 JP JP2002532446A patent/JP2004510775A/ja active Pending
- 2001-10-01 CA CA002421776A patent/CA2421776A1/en not_active Abandoned
- 2001-10-01 AU AU2001292503A patent/AU2001292503A1/en not_active Abandoned
- 2001-10-01 EP EP07121849A patent/EP1900741A1/en not_active Withdrawn
- 2001-10-01 IL IL15480301A patent/IL154803A0/xx active IP Right Grant
- 2001-10-01 US US10/381,900 patent/US6936712B1/en not_active Expired - Fee Related
- 2001-10-01 NZ NZ524573A patent/NZ524573A/en unknown
- 2001-10-01 EE EEP200300131A patent/EE200300131A/xx unknown
- 2001-10-01 MX MXPA03002759A patent/MXPA03002759A/es active IP Right Grant
- 2001-10-01 CN CNB018167225A patent/CN1243754C/zh not_active Expired - Fee Related
- 2001-10-01 EP EP01972865A patent/EP1330461A1/en not_active Withdrawn
- 2001-10-01 WO PCT/SE2001/002130 patent/WO2002028864A1/en not_active Ceased
- 2001-10-01 WO PCT/SE2001/002129 patent/WO2002028863A1/en not_active Ceased
- 2001-10-01 NZ NZ524574A patent/NZ524574A/en unknown
- 2001-10-01 SK SK386-2003A patent/SK3862003A3/sk not_active Application Discontinuation
- 2001-10-01 CN CNA018167217A patent/CN1468244A/zh active Pending
- 2001-10-01 KR KR10-2003-7004638A patent/KR20030032060A/ko not_active Withdrawn
- 2001-10-01 BR BR0114366-2A patent/BR0114366A/pt not_active IP Right Cessation
- 2001-10-01 IL IL15480201A patent/IL154802A0/xx unknown
- 2001-10-01 CA CA002422810A patent/CA2422810A1/en not_active Abandoned
- 2001-10-01 CZ CZ2003923A patent/CZ294217B6/cs not_active IP Right Cessation
- 2001-10-01 HU HU0302288A patent/HUP0302288A3/hu unknown
- 2001-10-01 CN CNA2005100035779A patent/CN1793146A/zh active Pending
- 2001-10-01 BR BR0114367-0A patent/BR0114367A/pt not_active IP Right Cessation
- 2001-10-01 MX MXPA03002679A patent/MXPA03002679A/es not_active Application Discontinuation
- 2001-10-01 PL PL01364047A patent/PL364047A1/xx not_active Application Discontinuation
- 2001-10-01 AU AU2001292504A patent/AU2001292504B2/en not_active Ceased
- 2001-10-01 KR KR1020037004639A patent/KR100812920B1/ko not_active Expired - Fee Related
- 2001-10-01 JP JP2002532447A patent/JP4248873B2/ja not_active Expired - Fee Related
- 2001-10-01 EP EP01972866A patent/EP1330462A1/en not_active Withdrawn
- 2001-10-01 US US10/398,171 patent/US20040039199A1/en not_active Abandoned
-
2003
- 2003-03-03 ZA ZA200301757A patent/ZA200301757B/en unknown
- 2003-03-06 IL IL154803A patent/IL154803A/en not_active IP Right Cessation
- 2003-03-13 IS IS6744A patent/IS6744A/is unknown
- 2003-03-18 ZA ZA200302202A patent/ZA200302202B/en unknown
- 2003-03-27 NO NO20031413A patent/NO20031413L/no not_active Application Discontinuation
- 2003-03-27 NO NO20031414A patent/NO20031414L/no not_active Application Discontinuation
-
2005
- 2005-03-25 US US11/089,325 patent/US7439355B2/en not_active Expired - Fee Related
-
2008
- 2008-09-15 US US12/232,293 patent/US20090036675A1/en not_active Abandoned
-
2009
- 2009-03-06 US US12/382,068 patent/US20090240051A1/en not_active Abandoned
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