JP2004510752A5 - - Google Patents
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- JP2004510752A5 JP2004510752A5 JP2002532304A JP2002532304A JP2004510752A5 JP 2004510752 A5 JP2004510752 A5 JP 2004510752A5 JP 2002532304 A JP2002532304 A JP 2002532304A JP 2002532304 A JP2002532304 A JP 2002532304A JP 2004510752 A5 JP2004510752 A5 JP 2004510752A5
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- JP
- Japan
- Prior art keywords
- cells
- antibody
- monoclonal antibody
- fragment
- malignant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 98
- 239000012634 fragment Substances 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 67
- 230000003211 malignant effect Effects 0.000 claims description 34
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 29
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 108010063916 CD40 Antigens Proteins 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 16
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 208000017604 Hodgkin disease Diseases 0.000 claims description 8
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 8
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 8
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 8
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 8
- 208000034578 Multiple myelomas Diseases 0.000 claims description 8
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 8
- 239000000556 agonist Substances 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 239000005557 antagonist Substances 0.000 claims description 8
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 208000021173 high grade B-cell lymphoma Diseases 0.000 claims description 8
- 210000004408 hybridoma Anatomy 0.000 claims description 8
- 208000025113 myeloid leukemia Diseases 0.000 claims description 8
- 230000035755 proliferation Effects 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 230000004797 therapeutic response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 4
- 230000005593 dissociations Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 description 53
- 230000001154 acute effect Effects 0.000 description 4
- 208000032839 leukemia Diseases 0.000 description 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23755600P | 2000-10-02 | 2000-10-02 | |
| PCT/US2001/030963 WO2002028481A2 (en) | 2000-10-02 | 2001-10-02 | Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007305086A Division JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Division JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510752A JP2004510752A (ja) | 2004-04-08 |
| JP2004510752A5 true JP2004510752A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
| JP4202127B2 JP4202127B2 (ja) | 2008-12-24 |
Family
ID=22894238
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532304A Expired - Fee Related JP4202127B2 (ja) | 2000-10-02 | 2001-10-02 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2002532486A Expired - Lifetime JP4271440B2 (ja) | 2000-10-02 | 2001-10-02 | ヒト抗ｃｄ４０抗体 |
| JP2007299859A Pending JP2008156339A (ja) | 2000-10-02 | 2007-11-19 | ヒト抗ｃｄ４０抗体 |
| JP2007305086A Pending JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Expired - Fee Related JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2009143746A Pending JP2009201523A (ja) | 2000-10-02 | 2009-06-16 | ヒト抗ｃｄ４０抗体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532486A Expired - Lifetime JP4271440B2 (ja) | 2000-10-02 | 2001-10-02 | ヒト抗ｃｄ４０抗体 |
| JP2007299859A Pending JP2008156339A (ja) | 2000-10-02 | 2007-11-19 | ヒト抗ｃｄ４０抗体 |
| JP2007305086A Pending JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Expired - Fee Related JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2009143746A Pending JP2009201523A (ja) | 2000-10-02 | 2009-06-16 | ヒト抗ｃｄ４０抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7288252B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1326896B1 (cg-RX-API-DMAC7.html) |
| JP (6) | JP4202127B2 (cg-RX-API-DMAC7.html) |
| AT (3) | ATE541860T1 (cg-RX-API-DMAC7.html) |
| AU (4) | AU2001296545A1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2424296A1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE60143535D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2357051T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1326896E (cg-RX-API-DMAC7.html) |
| WO (4) | WO2002028481A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (82)
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| WO2002028481A2 (en) * | 2000-10-02 | 2002-04-11 | Chiron Corporation | Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies |
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| US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
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| EP2589654A1 (en) * | 2006-05-03 | 2013-05-08 | The Regents of the University of Colorado, a body corporate | CD40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| DK2176298T3 (en) | 2007-05-30 | 2018-02-12 | Xencor Inc | Methods and compositions for inhibiting CD32B-expressing cells |
| RU2491095C2 (ru) * | 2007-11-09 | 2013-08-27 | Новартис Аг | Применения анти-cd40-антител |
| CA2712989C (en) * | 2008-01-23 | 2015-10-27 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| US8961991B2 (en) | 2009-03-10 | 2015-02-24 | Baylor Research Institute | Anti-CD40 targeted fusion proteins |
| AU2010222942B2 (en) | 2009-03-10 | 2013-01-10 | Baylor Research Institute | Anti-CD40 antibodies and uses thereof |
| CN103415534A (zh) | 2009-03-10 | 2013-11-27 | 贝勒研究院 | 靶向抗原呈递细胞的癌症疫苗 |
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2001
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- 2001-10-02 JP JP2002532304A patent/JP4202127B2/ja not_active Expired - Fee Related
- 2001-10-02 ES ES01979395T patent/ES2357051T3/es not_active Expired - Lifetime
- 2001-10-02 AT AT06005656T patent/ATE541860T1/de active
- 2001-10-02 AU AU2001296545A patent/AU2001296545A1/en not_active Abandoned
- 2001-10-02 DE DE60143535T patent/DE60143535D1/de not_active Expired - Lifetime
- 2001-10-02 AT AT01979395T patent/ATE489403T1/de active
- 2001-10-02 AU AU2002211366A patent/AU2002211366A1/en not_active Abandoned
- 2001-10-02 PT PT01979395T patent/PT1326896E/pt unknown
- 2001-10-02 DE DE60119945T patent/DE60119945T2/de not_active Expired - Lifetime
- 2001-10-02 CA CA002424296A patent/CA2424296A1/en not_active Abandoned
- 2001-10-02 JP JP2002532486A patent/JP4271440B2/ja not_active Expired - Lifetime
- 2001-10-02 AT AT01977428T patent/ATE327004T1/de not_active IP Right Cessation
- 2001-10-02 WO PCT/US2001/030859 patent/WO2002028905A2/en not_active Ceased
- 2001-10-02 US US10/380,223 patent/US7288252B2/en not_active Expired - Fee Related
- 2001-10-02 EP EP01979395A patent/EP1326896B1/en not_active Expired - Lifetime
- 2001-10-02 WO PCT/US2001/030961 patent/WO2002028480A2/en not_active Ceased
- 2001-10-02 AU AU2001296507A patent/AU2001296507A1/en not_active Abandoned
- 2001-10-02 EP EP01977428A patent/EP1322383B9/en not_active Expired - Lifetime
- 2001-10-02 CA CA002424749A patent/CA2424749A1/en not_active Abandoned
- 2001-10-02 EP EP06005656A patent/EP1717251B1/en not_active Expired - Lifetime
- 2001-10-02 WO PCT/US2001/030857 patent/WO2002028904A2/en not_active Ceased
- 2001-10-02 AU AU2001296547A patent/AU2001296547A1/en not_active Abandoned
-
2007
- 2007-08-31 US US11/849,107 patent/US7445780B2/en not_active Expired - Fee Related
- 2007-11-19 JP JP2007299859A patent/JP2008156339A/ja active Pending
- 2007-11-26 JP JP2007305086A patent/JP2008074870A/ja active Pending
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2008
- 2008-08-28 JP JP2008220544A patent/JP4838831B2/ja not_active Expired - Fee Related
- 2008-10-06 US US12/246,029 patent/US7611708B2/en not_active Expired - Fee Related
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2009
- 2009-06-16 JP JP2009143746A patent/JP2009201523A/ja active Pending
- 2009-09-28 US US12/568,373 patent/US7820170B2/en not_active Expired - Fee Related
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2010
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