JP2004510749A5 - - Google Patents
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- Publication number
- JP2004510749A5 JP2004510749A5 JP2002532257A JP2002532257A JP2004510749A5 JP 2004510749 A5 JP2004510749 A5 JP 2004510749A5 JP 2002532257 A JP2002532257 A JP 2002532257A JP 2002532257 A JP2002532257 A JP 2002532257A JP 2004510749 A5 JP2004510749 A5 JP 2004510749A5
- Authority
- JP
- Japan
- Prior art keywords
- agonist
- ppardelta
- activator
- ppar delta
- synthase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010015181 PPAR delta Proteins 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 5
- 229940122054 Peroxisome proliferator-activated receptor delta agonist Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 3
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- YDBLKRPLXZNVNB-UHFFFAOYSA-N GW 501516 Chemical group CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC=C(OCC(O)=O)C(C)=C1 YDBLKRPLXZNVNB-UHFFFAOYSA-N 0.000 claims 1
- 101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 claims 1
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024362.6A GB0024362D0 (en) | 2000-10-05 | 2000-10-05 | Medicaments |
| PCT/GB2001/004370 WO2002028433A2 (en) | 2000-10-05 | 2001-10-02 | Use of a ppar delta activator in the treatment of diseases related to no inhibit ion or tnf inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004510749A JP2004510749A (ja) | 2004-04-08 |
| JP2004510749A5 true JP2004510749A5 (https=) | 2005-12-22 |
Family
ID=9900710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532257A Pending JP2004510749A (ja) | 2000-10-05 | 2001-10-02 | Ｎｏ阻害またはｔｎｆ阻害に関連した疾病の治療におけるｐｐａｒデルタ活性化因子の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040029938A1 (https=) |
| EP (1) | EP1324773A2 (https=) |
| JP (1) | JP2004510749A (https=) |
| AU (1) | AU2001292044A1 (https=) |
| GB (1) | GB0024362D0 (https=) |
| WO (1) | WO2002028433A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0212512A (pt) | 2001-09-14 | 2004-10-26 | Tularik Inc | Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta |
| US20070037882A1 (en) * | 2003-04-22 | 2007-02-15 | Astellas Pharma Inc. | Remedy for cerebral neurodegenerative diseases using ppar agonist |
| CA2525764C (en) * | 2003-05-20 | 2012-07-17 | Novartis Ag | N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors |
| RU2005141516A (ru) | 2003-06-06 | 2007-07-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные анилина |
| KR100796093B1 (ko) | 2003-07-02 | 2008-01-21 | 에프. 호프만-라 로슈 아게 | 티아졸 고리로 치환된 인돌릴 유도체 및 ｐｐａｒ조절제로서 그의 용도 |
| JP2007530703A (ja) * | 2004-04-01 | 2007-11-01 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | Ｍｓおよびその他の脱髄疾患を治療するためのペルオキシソーム増殖因子活性化受容体デルタアゴニストの使用 |
| US7126825B2 (en) * | 2004-12-07 | 2006-10-24 | Cleavage Enterprise Co., Ltd. | Combined chip/heat-dissipating metal plate and method for manufacturing the same |
| CN102724978A (zh) * | 2009-08-14 | 2012-10-10 | 塞伦尼斯治疗公司 | 用于治疗或预防炎症或能量代谢/产生相关疾病的PPARδ配体的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028149A1 (en) * | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| CA2295930C (en) * | 1997-07-24 | 2010-12-14 | Yamanouchi Pharmaceutical Co., Ltd. | Pharmaceutical compositions having cholesterol-lowering effect |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| EP1170008A1 (en) * | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
-
2000
- 2000-10-05 GB GBGB0024362.6A patent/GB0024362D0/en not_active Ceased
-
2001
- 2001-10-02 AU AU2001292044A patent/AU2001292044A1/en not_active Abandoned
- 2001-10-02 JP JP2002532257A patent/JP2004510749A/ja active Pending
- 2001-10-02 WO PCT/GB2001/004370 patent/WO2002028433A2/en not_active Ceased
- 2001-10-02 EP EP01972264A patent/EP1324773A2/en not_active Withdrawn
- 2001-10-02 US US10/398,417 patent/US20040029938A1/en not_active Abandoned
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