JP2004509617A5 - - Google Patents
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- JP2004509617A5 JP2004509617A5 JP2002525188A JP2002525188A JP2004509617A5 JP 2004509617 A5 JP2004509617 A5 JP 2004509617A5 JP 2002525188 A JP2002525188 A JP 2002525188A JP 2002525188 A JP2002525188 A JP 2002525188A JP 2004509617 A5 JP2004509617 A5 JP 2004509617A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- seq
- cells
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 description 28
- 108090000765 processed proteins & peptides Proteins 0.000 description 28
- 102000004196 processed proteins & peptides Human genes 0.000 description 28
- 108020004707 nucleic acids Proteins 0.000 description 22
- 102000039446 nucleic acids Human genes 0.000 description 22
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 241000288906 Primates Species 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000000890 antigenic effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000002029 Claudin Human genes 0.000 description 1
- 108050009302 Claudin Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23126700P | 2000-09-08 | 2000-09-08 | |
| PCT/US2001/028013 WO2002020569A2 (en) | 2000-09-08 | 2001-09-07 | Mammalian genes; related reagents and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008218815A Division JP2009039124A (ja) | 2000-09-08 | 2008-08-27 | 哺乳動物遺伝子；関連試薬および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509617A JP2004509617A (ja) | 2004-04-02 |
| JP2004509617A5 true JP2004509617A5 (https=) | 2008-10-16 |
Family
ID=22868480
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525188A Withdrawn JP2004509617A (ja) | 2000-09-08 | 2001-09-07 | 哺乳動物遺伝子；関連試薬および方法 |
| JP2008218815A Withdrawn JP2009039124A (ja) | 2000-09-08 | 2008-08-27 | 哺乳動物遺伝子；関連試薬および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008218815A Withdrawn JP2009039124A (ja) | 2000-09-08 | 2008-08-27 | 哺乳動物遺伝子；関連試薬および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US7060800B2 (https=) |
| EP (2) | EP2298789B1 (https=) |
| JP (2) | JP2004509617A (https=) |
| CN (1) | CN1452633A (https=) |
| AT (1) | ATE549347T1 (https=) |
| AU (1) | AU2001294541A1 (https=) |
| CA (1) | CA2419979A1 (https=) |
| MX (1) | MXPA03002049A (https=) |
| WO (1) | WO2002020569A2 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2388019A1 (en) * | 1999-11-05 | 2001-05-17 | Human Genome Sciences, Inc. | 24 human secreted proteins |
| US6897292B2 (en) | 1999-12-03 | 2005-05-24 | Zymogenetics, Inc. | Human cytokine receptor |
| US20030170823A1 (en) | 1999-12-23 | 2003-09-11 | Presnell Scott R. | Novel cytokine ZCYTO18 |
| ES2381650T3 (es) | 2000-08-08 | 2012-05-30 | Zymogenetics, Inc. | Receptores de citoquinas Zcytor11 solubles |
| US7358353B2 (en) | 2000-08-22 | 2008-04-15 | Agensys, Inc. | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers |
| CA2420543C (en) * | 2000-08-22 | 2013-04-02 | Agensys, Inc. | Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers |
| JP2004509617A (ja) * | 2000-09-08 | 2004-04-02 | シェーリング コーポレイション | 哺乳動物遺伝子；関連試薬および方法 |
| US20020151695A1 (en) * | 2000-11-28 | 2002-10-17 | Shuqian Jing | Transforming growth factor-beta-related molecules and uses thereof |
| ES2334888T3 (es) * | 2000-11-28 | 2010-03-17 | Zymogenetics, L.L.C. | Receptor de citocina zcytor19. |
| US20030099608A1 (en) | 2001-03-27 | 2003-05-29 | Presnell Scott R. | Human cytokine receptor |
| US7910313B2 (en) | 2001-04-20 | 2011-03-22 | Zymogenetics, Inc. | Cytokine protein family |
| US7038032B2 (en) | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
| WO2003031620A1 (en) * | 2001-10-02 | 2003-04-17 | Mochida Pharmaceutical Co., Ltd. | Novel class ii cytokine receptor |
| US7033787B2 (en) * | 2001-12-21 | 2006-04-25 | Ludwig Institute For Cancer Research | Isolated cytokine receptor LICR-2 |
| EP1546358A4 (en) | 2002-03-22 | 2006-06-07 | Zymogenetics Inc | ANTI-IL-TIF ANTIBODIES AND METHOD FOR USE ON INFLAMMATION |
| EP2295455A1 (en) | 2002-04-19 | 2011-03-16 | ZymoGenetics, L.L.C. | Cytokine receptor |
| US7141381B2 (en) | 2002-04-25 | 2006-11-28 | Bristol-Myers Squibb Company | Human leucine-rich repeat-containing proteins specifically expressed in the nervous system |
| WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
| EP1575609A4 (en) | 2002-10-23 | 2010-12-15 | Zymogenetics L L C | METHOD FOR THE TREATMENT OF VIRUS INFECTIONS USING IL-28 AND IL-29 |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| CA2515699C (en) * | 2003-02-10 | 2015-01-27 | Aya Jakobovits | Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers |
| EP1606316A2 (en) | 2003-03-24 | 2005-12-21 | ZymoGenetics, Inc. | Anti-il-20 antibodies and binding partners and methods of using in inflammation |
| EP1927600A1 (en) | 2003-08-07 | 2008-06-04 | Zymogenetics, Inc. | Homogeneous preparations of IL-28 and IL-29 |
| PT1663281E (pt) * | 2003-08-29 | 2014-03-17 | Dyax Corp | Inibidores de proteases poli-peguilados |
| GB0325038D0 (en) * | 2003-10-27 | 2003-12-03 | Ares Trading Sa | Protein |
| WO2005097165A2 (en) | 2004-04-02 | 2005-10-20 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| CA2574564C (en) | 2004-07-29 | 2013-04-16 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer and autoimmune disorders |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP4898691B2 (ja) | 2004-10-22 | 2012-03-21 | ザイモジェネティクス， インコーポレイテッド | 抗ｉｌ−２２ｒａ抗体および結合パートナー、ならびに炎症における使用法 |
| GB0423973D0 (en) * | 2004-10-28 | 2004-12-01 | Ares Trading Sa | C1q related points |
| JP2008539194A (ja) * | 2005-04-26 | 2008-11-13 | ラボラトワール セローノ ソシエテ アノニム | 癌および／または関節炎の新たな治療および／または予防 |
| CA2616004A1 (en) | 2005-07-20 | 2007-02-01 | Zymogenetics, Inc. | Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| TW200902025A (en) * | 2007-04-11 | 2009-01-16 | Alcon Res Ltd | Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| PL3604510T3 (pl) | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| PT2453910T (pt) | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
| US20110082145A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| WO2013016449A2 (en) | 2011-07-26 | 2013-01-31 | Indicator Systems International, Inc. | Assays for the detection of microbes |
| JP6200437B2 (ja) | 2012-03-16 | 2017-09-20 | ユニバーシティ ヘルス ネットワーク | Ｔｏｓｏ活性を調節するための方法および組成物 |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| EP3494996B1 (en) | 2012-08-23 | 2026-04-15 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to 158p1d7 proteins |
| WO2014075788A1 (en) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| EP3113798B1 (en) | 2014-03-07 | 2019-06-05 | University Health Network | Methods and compositions for modifying the immune response |
| IL295414B2 (en) | 2014-03-27 | 2026-02-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema due to diabetes |
| WO2017011275A1 (en) | 2015-07-10 | 2017-01-19 | Nersissian Aram M | Factor viii protein compositions and methods of treating hemophilia a |
| AU2016303688B2 (en) | 2015-07-31 | 2023-06-15 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
| WO2017066719A2 (en) | 2015-10-14 | 2017-04-20 | Research Institute At Nationwide Children's Hospital | Hu specific interfering agents |
| JP7514621B2 (ja) | 2017-01-04 | 2024-07-11 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | Ｄｎａｂｉｉワクチンおよび強化された活性を有する抗体 |
| AU2018206560B9 (en) | 2017-01-04 | 2025-04-03 | Research Institute At Nationwide Children's Hospital | Antibody fragments for the treatment of biofilm-related disorders |
| AU2018236271B2 (en) | 2017-03-15 | 2023-12-21 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
| CN110229226B (zh) * | 2019-05-23 | 2023-04-11 | 西安医学院 | 一种slfn11截断肽及其应用和药物组合物 |
| WO2021007260A2 (en) | 2019-07-08 | 2021-01-14 | Research Institute At Nationwide Children's Hospital | Antibody compositions for disrupting biofilms |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US88426A (en) | 1869-03-30 | Improved velocipede | ||
| US2736896A (en) | 1951-12-04 | 1956-02-28 | Sperry Rand Corp | Horn antenna system |
| DE2031216A1 (de) | 1969-06-19 | 1971-01-14 | Citizen Watch Co Ltd , Tokio | Tag und Datum Stellvorrichtung fur Uhren mit Kalender |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4859609A (en) | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| JP2004509617A (ja) * | 2000-09-08 | 2004-04-02 | シェーリング コーポレイション | 哺乳動物遺伝子；関連試薬および方法 |
| US11068393B2 (en) | 2019-10-17 | 2021-07-20 | Microsoft Technology Licensing, Llc | Enhanced concurrency garbage collection stack scanning |
-
2001
- 2001-09-07 JP JP2002525188A patent/JP2004509617A/ja not_active Withdrawn
- 2001-09-07 CA CA002419979A patent/CA2419979A1/en not_active Abandoned
- 2001-09-07 WO PCT/US2001/028013 patent/WO2002020569A2/en not_active Ceased
- 2001-09-07 AT AT10179792T patent/ATE549347T1/de active
- 2001-09-07 US US09/949,192 patent/US7060800B2/en not_active Expired - Fee Related
- 2001-09-07 EP EP10179792A patent/EP2298789B1/en not_active Expired - Lifetime
- 2001-09-07 AU AU2001294541A patent/AU2001294541A1/en not_active Abandoned
- 2001-09-07 MX MXPA03002049A patent/MXPA03002049A/es unknown
- 2001-09-07 CN CN01815161A patent/CN1452633A/zh active Pending
- 2001-09-07 EP EP01975188A patent/EP1315743B1/en not_active Expired - Lifetime
-
2005
- 2005-03-25 US US11/090,448 patent/US7427668B2/en not_active Expired - Fee Related
-
2008
- 2008-08-27 JP JP2008218815A patent/JP2009039124A/ja not_active Withdrawn
- 2008-09-22 US US12/235,404 patent/US7696317B2/en not_active Expired - Fee Related
-
2009
- 2009-12-22 US US12/644,404 patent/US7893211B2/en not_active Expired - Fee Related
-
2010
- 2010-12-21 US US12/974,559 patent/US8148507B2/en not_active Expired - Fee Related
-
2012
- 2012-03-07 US US13/414,496 patent/US8426573B2/en not_active Expired - Fee Related
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