JP2004509084A5 - - Google Patents
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- Publication number
- JP2004509084A5 JP2004509084A5 JP2002523473A JP2002523473A JP2004509084A5 JP 2004509084 A5 JP2004509084 A5 JP 2004509084A5 JP 2002523473 A JP2002523473 A JP 2002523473A JP 2002523473 A JP2002523473 A JP 2002523473A JP 2004509084 A5 JP2004509084 A5 JP 2004509084A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- cycloalkyl
- aryl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 11
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- -1 polymethylene chain Polymers 0.000 description 8
- 125000000753 cycloalkyl group Chemical group 0.000 description 7
- 125000001475 halogen functional group Chemical group 0.000 description 7
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 description 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 6
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
- 150000004677 hydrates Chemical class 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000012453 solvate Substances 0.000 description 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 4
- 125000004103 aminoalkyl group Chemical group 0.000 description 4
- 125000001188 haloalkyl group Chemical group 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 3
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 description 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
- AZFFNZFFAWPVGO-UHFFFAOYSA-N 2-[2-methyl-4-[[5-methyl-2-(4-phenylmethoxyphenyl)-1,3-oxazol-4-yl]methoxy]phenoxy]acetic acid Chemical compound CC=1OC(C=2C=CC(OCC=3C=CC=CC=3)=CC=2)=NC=1COC1=CC=C(OCC(O)=O)C(C)=C1 AZFFNZFFAWPVGO-UHFFFAOYSA-N 0.000 description 1
- FDXZNRILKJRXFZ-UHFFFAOYSA-N 2-[4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methylsulfanyl]-2-propylphenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(CCC)=CC(SCC2=C(OC(=N2)C=2C=CC=CC=2)C)=C1 FDXZNRILKJRXFZ-UHFFFAOYSA-N 0.000 description 1
- DKFOBENNWPSTSZ-UHFFFAOYSA-N 2-[4-[2-[2-(4-butoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethylsulfanyl]-2-methylphenoxy]acetic acid Chemical compound C1=CC(OCCCC)=CC=C1C1=NC(CCSC=2C=C(C)C(OCC(O)=O)=CC=2)=C(C)O1 DKFOBENNWPSTSZ-UHFFFAOYSA-N 0.000 description 1
- ICGGAQRMHQTVIJ-UHFFFAOYSA-N 2-[4-[[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfanyl]-2-propylphenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(CCC)=CC(SCC2=C(OC(=N2)C=2C=CC(Br)=CC=2)C)=C1 ICGGAQRMHQTVIJ-UHFFFAOYSA-N 0.000 description 1
- MXSBPMNCHHMWGK-UHFFFAOYSA-N 2-[4-[[5-methyl-2-(4-phenylmethoxyphenyl)-1,3-oxazol-4-yl]methoxy]phenoxy]acetic acid Chemical compound CC=1OC(C=2C=CC(OCC=3C=CC=CC=3)=CC=2)=NC=1COC1=CC=C(OCC(O)=O)C=C1 MXSBPMNCHHMWGK-UHFFFAOYSA-N 0.000 description 1
- UOWSULYBSTUTCV-UHFFFAOYSA-N 2-[4-[[5-methyl-2-(4-phenylmethoxyphenyl)-1,3-oxazol-4-yl]methylsulfanyl]-2-propylphenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(CCC)=CC(SCC2=C(OC(=N2)C=2C=CC(OCC=3C=CC=CC=3)=CC=2)C)=C1 UOWSULYBSTUTCV-UHFFFAOYSA-N 0.000 description 1
- VUWCWQJMPHAOGO-UHFFFAOYSA-N 2-[4-[[5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methylsulfanyl]-2-propylphenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(CCC)=CC(SCC2=C(OC(=N2)C=2C=CC(=CC=2)C(F)(F)F)C)=C1 VUWCWQJMPHAOGO-UHFFFAOYSA-N 0.000 description 1
- FDUADOLBLVYJOH-UHFFFAOYSA-N 4-[4-[[4-(carboxymethoxy)-3-methylphenoxy]methyl]-5-methyl-1,3-oxazol-2-yl]benzoic acid Chemical compound CC=1OC(C=2C=CC(=CC=2)C(O)=O)=NC=1COC1=CC=C(OCC(O)=O)C(C)=C1 FDUADOLBLVYJOH-UHFFFAOYSA-N 0.000 description 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 1
- 102000023984 PPAR alpha Human genes 0.000 description 1
- 108010015181 PPAR delta Proteins 0.000 description 1
- 108010016731 PPAR gamma Proteins 0.000 description 1
- 102000000536 PPAR gamma Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 125000004171 alkoxy aryl group Chemical group 0.000 description 1
- 125000006307 alkoxy benzyl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000000000 cycloalkoxy group Chemical group 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 125000004470 heterocyclooxy group Chemical group 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000004957 naphthylene group Chemical group 0.000 description 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22723300P | 2000-08-23 | 2000-08-23 | |
| PCT/US2001/022615 WO2002018355A1 (en) | 2000-08-23 | 2001-08-23 | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509084A JP2004509084A (ja) | 2004-03-25 |
| JP2004509084A5 true JP2004509084A5 (https=) | 2008-10-09 |
Family
ID=22852305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002523473A Revoked JP2004509084A (ja) | 2000-08-23 | 2001-08-23 | オキサゾリル−アリールオキシ酢酸誘導体およびそのｐｐａｒアゴニストとしての使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6982278B2 (https=) |
| EP (1) | EP1313715B1 (https=) |
| JP (1) | JP2004509084A (https=) |
| AT (1) | ATE368653T1 (https=) |
| AU (1) | AU2001284658A1 (https=) |
| CA (1) | CA2420178A1 (https=) |
| DE (1) | DE60129712T2 (https=) |
| ES (1) | ES2288982T3 (https=) |
| WO (1) | WO2002018355A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| DE60129712T2 (de) * | 2000-08-23 | 2008-07-03 | Eli Lilly And Co., Indianapolis | Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten |
| EP1313717B1 (en) | 2000-08-23 | 2007-10-17 | Eli Lilly And Company | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| HUP0300857A3 (en) | 2000-08-23 | 2007-03-28 | Lilly Co Eli | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| US7105551B2 (en) | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| EA200400011A1 (ru) * | 2001-06-07 | 2004-06-24 | Эли Лилли Энд Компани | Модуляторы рецепторов, активируемых пролифераторами пероксисом (prar) |
| AR036237A1 (es) | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
| US20110065129A1 (en) | 2001-07-27 | 2011-03-17 | Lowe Derek B | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| ITRM20020014A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| ES2290439T3 (es) | 2002-02-25 | 2008-02-16 | Eli Lilly And Company | Moduladores del receptor activado del proliferador de peroxisomas. |
| ES2316736T3 (es) | 2002-02-25 | 2009-04-16 | Eli Lilly And Company | Moduladores de receptores activados por proliferador de peroxisoma. |
| US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| UA79755C2 (en) * | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| WO2004011446A1 (en) * | 2002-07-26 | 2004-02-05 | Bayer Pharmaceuticals Corporation | Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics |
| US7129268B2 (en) * | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
| CN1711084B (zh) * | 2002-11-08 | 2010-04-28 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的取代4-烷氧基噁唑衍生物 |
| US7192970B2 (en) * | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
| DE10308351A1 (de) | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| CA2532026C (en) | 2003-08-20 | 2012-04-17 | Eli Lilly And Company | Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide |
| ATE361294T1 (de) * | 2003-08-20 | 2007-05-15 | Lilly Co Eli | Verbindungen, verfahren und formulierungen zur oralen verabreichung einer glucagonartigen peptid (glp)-1-verbindung oder eines melanocortin-4- rezeptor-(mc4-)agonistschen peptids |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| CN1875002B (zh) * | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
| EP1682507A1 (en) * | 2003-11-05 | 2006-07-26 | F. Hoffmann-La Roche Ag | Benzannelated compounds as ppar activators |
| ES2347578T3 (es) * | 2004-05-05 | 2010-11-02 | High Point Pharmaceuticals, Llc | Derivados del acido fenoxiacetico como agonistas de ppar. |
| US8053598B2 (en) * | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
| JP2007284352A (ja) * | 2004-08-05 | 2007-11-01 | Dai Ichi Seiyaku Co Ltd | ピラゾール誘導体 |
| WO2006108491A1 (en) * | 2005-04-11 | 2006-10-19 | Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg | Improved process for preparing oxazole nitriles |
| CN103224477A (zh) | 2005-12-22 | 2013-07-31 | 高点制药有限责任公司 | 作为PPAR-δ活化剂的苯氧基乙酸 |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| TW201000107A (en) * | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
| WO2010118155A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| CA2757622A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| MX361692B (es) | 2010-02-03 | 2018-12-13 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de ácido graso. |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CN104230836B (zh) * | 2014-09-29 | 2016-08-31 | 中国科学院成都生物研究所 | 苯基噁唑类化合物及在制备治疗癌症的药中的应用 |
| DK3362462T3 (da) | 2015-10-12 | 2021-10-11 | Advanced Cell Diagnostics Inc | In situ-detektion af nukleotidvarianter i prøver med højt støjniveau, og sammensætninger og fremgangsmåder relateret dertil |
| AU2021312855A1 (en) | 2020-07-22 | 2023-03-09 | Reneo Pharmaceuticals, Inc. | Crystalline PPAR-delta agonist |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| US5232945A (en) * | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
| US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| JPH08325250A (ja) * | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規置換フェノール誘導体 |
| EP0888278B1 (en) | 1996-02-02 | 2003-07-23 | Merck & Co., Inc. | Antidiabetic agents |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| US6204277B1 (en) | 1996-08-19 | 2001-03-20 | Japan Tobacco Inc. | Propionic acid derivatives and applications thereof |
| ATE451346T1 (de) | 1998-03-10 | 2009-12-15 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| US6121300A (en) * | 1998-11-10 | 2000-09-19 | Wagle; Dilip R. | Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts |
| DE60005973T2 (de) * | 1999-08-27 | 2004-05-13 | Eli Lilly And Co., Indianapolis | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren |
| JP4316787B2 (ja) * | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
| DE60129712T2 (de) * | 2000-08-23 | 2008-07-03 | Eli Lilly And Co., Indianapolis | Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten |
| HUP0300857A3 (en) | 2000-08-23 | 2007-03-28 | Lilly Co Eli | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| EP1313717B1 (en) * | 2000-08-23 | 2007-10-17 | Eli Lilly And Company | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
-
2001
- 2001-08-23 DE DE60129712T patent/DE60129712T2/de not_active Expired - Lifetime
- 2001-08-23 JP JP2002523473A patent/JP2004509084A/ja not_active Revoked
- 2001-08-23 AT AT01963732T patent/ATE368653T1/de not_active IP Right Cessation
- 2001-08-23 EP EP01963732A patent/EP1313715B1/en not_active Expired - Lifetime
- 2001-08-23 ES ES01963732T patent/ES2288982T3/es not_active Expired - Lifetime
- 2001-08-23 WO PCT/US2001/022615 patent/WO2002018355A1/en not_active Ceased
- 2001-08-23 AU AU2001284658A patent/AU2001284658A1/en not_active Abandoned
- 2001-08-23 CA CA002420178A patent/CA2420178A1/en not_active Abandoned
- 2001-08-23 US US10/343,474 patent/US6982278B2/en not_active Expired - Fee Related
-
2005
- 2005-07-14 US US11/181,640 patent/US7351728B2/en not_active Expired - Fee Related
-
2008
- 2008-01-11 US US11/972,668 patent/US20080146631A1/en not_active Abandoned
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