JP2004508448A5 - - Google Patents

Download PDF

Info

Publication number
JP2004508448A5
JP2004508448A5 JP2002525681A JP2002525681A JP2004508448A5 JP 2004508448 A5 JP2004508448 A5 JP 2004508448A5 JP 2002525681 A JP2002525681 A JP 2002525681A JP 2002525681 A JP2002525681 A JP 2002525681A JP 2004508448 A5 JP2004508448 A5 JP 2004508448A5
Authority
JP
Japan
Prior art keywords
oxazine derivative
studied
labeled
oxazine
derivative according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002525681A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004508448A (ja
Filing date
Publication date
Priority claimed from EP00127005A external-priority patent/EP1213328A1/de
Application filed filed Critical
Priority claimed from PCT/EP2001/010236 external-priority patent/WO2002020670A1/de
Publication of JP2004508448A publication Critical patent/JP2004508448A/ja
Publication of JP2004508448A5 publication Critical patent/JP2004508448A5/ja
Pending legal-status Critical Current

Links

JP2002525681A 2000-09-06 2001-09-05 オキサジン誘導体 Pending JP2004508448A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00119292 2000-09-06
EP00127005A EP1213328A1 (de) 2000-12-08 2000-12-08 Oxazinderivate
PCT/EP2001/010236 WO2002020670A1 (de) 2000-09-06 2001-09-05 Oxazinderivate

Publications (2)

Publication Number Publication Date
JP2004508448A JP2004508448A (ja) 2004-03-18
JP2004508448A5 true JP2004508448A5 (https=) 2008-10-09

Family

ID=26071369

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002525681A Pending JP2004508448A (ja) 2000-09-06 2001-09-05 オキサジン誘導体

Country Status (6)

Country Link
US (2) US7101999B2 (https=)
EP (2) EP1535967B1 (https=)
JP (1) JP2004508448A (https=)
AT (2) ATE518913T1 (https=)
DE (1) DE50105139D1 (https=)
WO (1) WO2002020670A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE518913T1 (de) 2000-09-06 2011-08-15 Evotec Ag Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarker
DE10212960A1 (de) * 2002-03-22 2003-10-23 Gnothis Holding Sa Ecublens Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse
BRPI0413703A (pt) * 2003-08-18 2006-10-17 Novartis Ag derivados de 3h-fenoxazina adequados como agentes formadores de imagem do infravermelho próximo, preparação e uso dos mesmos
EP1607393A1 (fr) * 2004-06-18 2005-12-21 L'oreal Compositions comprenant des colorants directs hydroxyalkyles, procédés de mise en oeuvre et utilisations.
US7326258B2 (en) * 2004-06-18 2008-02-05 L'oreal S.A. Compositions comprising hydroxyalkyl direct dyes, implementation processes and uses thereof
US8187825B2 (en) 2008-02-29 2012-05-29 Riken Thiol detection method
US20120010404A1 (en) * 2008-06-10 2012-01-12 Sigma-Aldrich Co. Oxazine dyes with improved aqueous solubility
GB0903348D0 (en) * 2009-02-27 2009-04-08 Pharmalucia Ltd Compounds and methods relating thereto
CN103044947B (zh) * 2013-01-09 2014-05-21 大连理工大学 一类尼罗蓝荧光染料，其制备方法及应用
US11077210B2 (en) 2013-10-31 2021-08-03 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE287040C (https=)
US1488609A (en) * 1924-04-01 murphy
JPS501576B2 (https=) * 1972-04-25 1975-01-20
GB1410815A (en) * 1972-12-20 1975-10-22 Ici Ltd Oxazine dyestuffs
DE2411761A1 (de) * 1974-03-12 1975-10-16 Hoechst Ag Basische oxazinfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung
US4622395A (en) * 1984-10-01 1986-11-11 Minnesota Mining And Manufacturing Company Phenoxazine and phenothiazine dyes and leuco forms thereof
US4714763A (en) 1985-07-11 1987-12-22 Viomedics Inc. Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels
US4780535A (en) * 1986-11-21 1988-10-25 Spyros Theodoropulos Maleic and phthalic diamides
US4965349A (en) 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US4962197A (en) * 1988-02-12 1990-10-09 Rowland Institute For Science Photo-inactivation of cancer cells
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
DD287040A5 (de) * 1989-07-28 1991-02-14 Veb Forschungszentrum Biotechnologie Berlin,De Neue fluophorderivate, verfahren zu ihrer herstellung und deren verwendung zur herstellung neuartiger fluoreszenzmarkierter nucleoside, nucleotide und oligonucleotide
GB9024775D0 (en) * 1990-11-14 1991-01-02 Axis Research Chemical compounds
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
JPH05170752A (ja) * 1991-04-26 1993-07-09 Takeda Chem Ind Ltd ３，７−ビス（ジ置換アミノ）フェノチアジン誘導体およびその製造法
DE59309805D1 (de) 1992-12-15 1999-11-04 Ciba Sc Holding Ag Oxazinfarbstoffe, Verfahren zu deren Herstellung und deren Verwendung
US5656759A (en) 1993-07-22 1997-08-12 Sony Corporation Hydrophobic cationic dye compounds
US5792389A (en) * 1993-10-27 1998-08-11 United States Of America Water soluble laser dyes
US5620842A (en) * 1995-03-29 1997-04-15 Becton Dickinson And Company Determination of the number of fluorescent molecules on calibration beads for flow cytometry
DE19521231A1 (de) * 1995-06-10 1996-12-12 Boehringer Mannheim Gmbh Neue Oxazinfarbstoffe und ihre Verwendung als Fluoreszenzmarker
GB9602265D0 (en) * 1996-02-05 1996-04-03 Amersham Int Plc Benzophenoxazine dyes
GB9716476D0 (en) * 1997-08-04 1997-10-08 Amersham Int Plc Dye intermediate and method
FR2780791B1 (fr) 1998-07-03 2000-09-01 Bio Merieux Methode de depistage ou de diagnostic d'un adenocarcinome ou d'une pathologie benigne de la prostate et procede de mise en oeuvre
US6140500A (en) * 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6727356B1 (en) * 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US6465644B1 (en) * 2000-05-02 2002-10-15 Applera Corporation Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates
ATE518913T1 (de) 2000-09-06 2011-08-15 Evotec Ag Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarker
EP1337851B1 (de) * 2000-11-16 2005-07-20 Roche Diagnostics GmbH Farbstoffpaare für fluoreszenz-resonanz-energie-transfer (fret) messungen

Similar Documents

Publication Publication Date Title
JP2502257B2 (ja) オリゴヌクレオチドの高分子支持体系
CN1325659C (zh) 标记和片段化dna的方法
JP2528107B2 (ja) ポリヌクレオチド測定試薬と方法
Seo et al. Click chemistry to construct fluorescent oligonucleotides for DNA sequencing
US6180348B1 (en) Method of isolating target specific oligonucleotide ligands
US4898951A (en) Compounds used as intermediates in the preparations of non-radioactive biological probes
JP2009137954A (ja) 標識試薬、このような試薬の合成方法および生体分子の検出方法
JP2000507091A (ja) 非蛍光標識を用いる、リガンド対の結合を検出するための方法および組成物
JP2004508448A5 (https=)
EP1563100A2 (en) Displacement sandwich immuno-pcr
JPH10502614A (ja) タグでコードされる複合体の組合せ化学ライブラリー
JPS62503103A (ja) ポリヌクレオドの誘導方法
JP2002503456A (ja) Ｐｎａおよびｄｎａ複合体およびその調製方法
JP3390468B2 (ja) 新規の無水混合物法による遺伝子プローブの結合方法
US20030186448A1 (en) Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
JP2022542756A (ja) 既存の化合物ライブラリーのタグ付け及びコード付けのための方法
CN1938329A (zh) 标记试剂、合成这样的试剂的方法和检测生物分子的方法
EP1454139A2 (en) Immobilizing biological molecules
JP4134351B2 (ja) 核酸結合用粒子担体
WO2001046471A1 (en) Expression of proteins from amplified, immobilized nucleic acids
CN101233410B (zh) 用于标记或处理包含目的生物分子特别是核酸的生物样品的方法
JPH084519B2 (ja) ハイブリッド形成用担体およびその調整方法
JP2005291952A (ja) 生体関連物質固定用粒子およびマイクロアレイ
JP2002071689A5 (https=)
JP2880996B2 (ja) ハイブリッド形成用担体およびその調製方法