JP2004508339A - 微生物病原体ワクチン - Google Patents
微生物病原体ワクチン Download PDFInfo
- Publication number
- JP2004508339A JP2004508339A JP2002524528A JP2002524528A JP2004508339A JP 2004508339 A JP2004508339 A JP 2004508339A JP 2002524528 A JP2002524528 A JP 2002524528A JP 2002524528 A JP2002524528 A JP 2002524528A JP 2004508339 A JP2004508339 A JP 2004508339A
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- JP
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- Prior art keywords
- vaccine
- stress
- gene
- heat shock
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0021757.0A GB0021757D0 (en) | 2000-09-04 | 2000-09-04 | Vaccine against microbial pathogens |
| PCT/GB2001/003964 WO2002020045A2 (en) | 2000-09-04 | 2001-09-04 | Vaccine against microbial pathogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508339A true JP2004508339A (ja) | 2004-03-18 |
| JP2004508339A5 JP2004508339A5 (enExample) | 2008-10-16 |
Family
ID=9898866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524528A Pending JP2004508339A (ja) | 2000-09-04 | 2001-09-04 | 微生物病原体ワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050232946A1 (enExample) |
| EP (1) | EP1315518B1 (enExample) |
| JP (1) | JP2004508339A (enExample) |
| CN (1) | CN1452495A (enExample) |
| AT (1) | ATE450270T1 (enExample) |
| AU (1) | AU2001284261A1 (enExample) |
| CA (1) | CA2421229A1 (enExample) |
| DE (1) | DE60140681D1 (enExample) |
| DK (1) | DK1315518T3 (enExample) |
| ES (1) | ES2337653T3 (enExample) |
| GB (1) | GB0021757D0 (enExample) |
| IL (1) | IL154727A0 (enExample) |
| PT (1) | PT1315518E (enExample) |
| WO (1) | WO2002020045A2 (enExample) |
| ZA (1) | ZA200301759B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010501595A (ja) * | 2006-09-01 | 2010-01-21 | シーエスエル、リミテッド | 免疫応答を誘発または誘導する方法 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1791811E (pt) * | 2004-09-21 | 2010-02-23 | Astellas Pharma Inc | ¿derivados de aminoálcool |
| WO2009021291A1 (en) * | 2007-08-16 | 2009-02-19 | The University Of Sydney | Mycobacterium vaccine formulation |
| SG185294A1 (en) | 2007-10-12 | 2012-11-29 | Csl Ltd | Method of eliciting an immune response against pandemic influenza virus |
| GB0910591D0 (en) | 2009-06-19 | 2009-07-29 | Immunobiology Ltd | Method for the purification of protein complexes |
| GB0916557D0 (en) | 2009-09-21 | 2009-10-28 | Health Prot Agency | Commensal neisserial stress protein complexes |
| GB201104897D0 (en) | 2011-03-23 | 2011-05-04 | Immunobiology Ltd | Method for the production of protein complexes and vaccine compositions comprising the same |
| CA2833633A1 (en) * | 2011-04-20 | 2012-10-26 | Jason Fisher | Composition and method for enhancing an immune response |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03204820A (ja) * | 1989-10-12 | 1991-09-06 | Nippon Saibai Suisan Kk | エビ類の細菌性疾病予防ワクチン及びその製造法 |
| JPH10291938A (ja) * | 1986-08-18 | 1998-11-04 | British Technol Group Ltd | 生ワクチン |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776724A (en) * | 1988-10-24 | 1998-07-07 | Yale University | Chaperonin-mediated protein folding |
| US6258359B1 (en) * | 1993-05-19 | 2001-07-10 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides |
| JPH08509873A (ja) * | 1993-05-19 | 1996-10-22 | アンスティテュ・パストゥール | ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列 |
| JPH0748398A (ja) * | 1993-08-03 | 1995-02-21 | Nippon Oil Co Ltd | 変性蛋白質の再生方法及び変性蛋白質再生剤 |
| US6420127B1 (en) * | 1994-11-18 | 2002-07-16 | Washington University | Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections |
| US6872542B1 (en) * | 1993-11-18 | 2005-03-29 | Siga Pharmaceuticals, Inc. | Treatment or prophylaxis of diseases caused by pilus-forming bacteria |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| CZ394297A3 (cs) * | 1995-06-07 | 1998-04-15 | Biochem Vaccines Inc. | Streptokokové proteiny teplotního šoku ze skupiny HSP70 |
| US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| JP2000502054A (ja) * | 1995-11-30 | 2000-02-22 | アグリカルチャー ビクトリア サービシーズ ピーティーワイ．エルティーディー． | 治療用および診断用の組成物 |
| US5747332A (en) * | 1996-09-20 | 1998-05-05 | University Of New Mexico | Methods for purifying and synthesizing heat shock protein complexes |
| EP0950061A4 (en) * | 1996-09-20 | 2000-04-12 | Univ New Mexico | Heat shock protein complexes |
| US6331388B1 (en) * | 1997-10-17 | 2001-12-18 | Wisconsin Alumni Research Foundation | Immune response enhancer |
| US5948646A (en) * | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| US6500434B1 (en) * | 1998-04-23 | 2002-12-31 | Medimmune, Inc. | Chaperone and adhesin proteins; vaccines, diagnostics and method for treating infections |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| AU770498B2 (en) * | 1998-06-19 | 2004-02-26 | Merieux Oravax | LT and CT in parenteral immunization methods against helicobacter infection |
| GB9818133D0 (en) * | 1998-08-19 | 1998-10-14 | Quadrant Holdings Cambridge | Vaccine |
| CA2363146A1 (en) * | 1999-02-22 | 2000-08-31 | Solomon Langermann | Caulobacter lps immunoadjuvant |
| US7041465B1 (en) * | 1999-08-11 | 2006-05-09 | Washington University | Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof |
| GB9919734D0 (en) * | 1999-08-19 | 1999-10-20 | Colaco Camilo | Vaccines from infectious agents |
| US6677139B1 (en) * | 1999-12-23 | 2004-01-13 | Genecor International, Inc. | Methods for production of proteins in host cells |
| GB0004547D0 (en) * | 2000-02-23 | 2000-04-19 | Immunobiology Ltd | Screening method for novel vaccine candidates and compositions obtained thereby |
| WO2001079259A1 (en) * | 2000-04-17 | 2001-10-25 | Rothman James E | Javelinization of protein antigens to heat shock proteins |
| CN1107681C (zh) * | 2000-08-11 | 2003-05-07 | 中国科学院微生物研究所 | 乙肝病毒抗原多肽与热休克蛋白的复合物及其应用 |
| US6932985B2 (en) * | 2000-10-10 | 2005-08-23 | Auburn University | Azide method and composition for controlling deleterious organisms |
| WO2002059156A2 (en) * | 2000-12-22 | 2002-08-01 | Medimmune, Inc. | Therapeutic compounds structurally-linked to bacterial polypeptides |
| AU2003216288B2 (en) * | 2002-02-13 | 2009-09-24 | Duke University | Modulation of immune response by non-peptide binding stress response polypeptides |
| WO2003074003A2 (en) * | 2002-03-01 | 2003-09-12 | Applied Immune Technologies | Immunogens for treatment of neoplastic and infectious disease |
| CA2483925A1 (en) * | 2002-05-02 | 2004-04-29 | University Of Connecticut Health Center | Using heat shock proteins and alpha-2-macroglobulins to increase immune response to vaccines comprising heat shock protein-peptide complexes or alpha-2-macroglobulin-peptide complexes |
-
2000
- 2000-09-04 GB GBGB0021757.0A patent/GB0021757D0/en not_active Ceased
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2001
- 2001-09-04 DK DK01963230.6T patent/DK1315518T3/da active
- 2001-09-04 AU AU2001284261A patent/AU2001284261A1/en not_active Abandoned
- 2001-09-04 US US10/363,454 patent/US20050232946A1/en not_active Abandoned
- 2001-09-04 PT PT01963230T patent/PT1315518E/pt unknown
- 2001-09-04 DE DE60140681T patent/DE60140681D1/de not_active Expired - Lifetime
- 2001-09-04 CA CA002421229A patent/CA2421229A1/en not_active Abandoned
- 2001-09-04 CN CN01815133A patent/CN1452495A/zh active Pending
- 2001-09-04 WO PCT/GB2001/003964 patent/WO2002020045A2/en not_active Ceased
- 2001-09-04 JP JP2002524528A patent/JP2004508339A/ja active Pending
- 2001-09-04 IL IL15472701A patent/IL154727A0/xx unknown
- 2001-09-04 ES ES01963230T patent/ES2337653T3/es not_active Expired - Lifetime
- 2001-09-04 EP EP01963230A patent/EP1315518B1/en not_active Expired - Lifetime
- 2001-09-04 AT AT01963230T patent/ATE450270T1/de active
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2003
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10291938A (ja) * | 1986-08-18 | 1998-11-04 | British Technol Group Ltd | 生ワクチン |
| JPH03204820A (ja) * | 1989-10-12 | 1991-09-06 | Nippon Saibai Suisan Kk | エビ類の細菌性疾病予防ワクチン及びその製造法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010501595A (ja) * | 2006-09-01 | 2010-01-21 | シーエスエル、リミテッド | 免疫応答を誘発または誘導する方法 |
Also Published As
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| US20050232946A1 (en) | 2005-10-20 |
| AU2001284261A1 (en) | 2002-03-22 |
| EP1315518B1 (en) | 2009-12-02 |
| PT1315518E (pt) | 2010-03-05 |
| GB0021757D0 (en) | 2000-10-18 |
| DK1315518T3 (da) | 2010-04-19 |
| DE60140681D1 (de) | 2010-01-14 |
| WO2002020045A2 (en) | 2002-03-14 |
| CN1452495A (zh) | 2003-10-29 |
| CA2421229A1 (en) | 2002-03-14 |
| EP1315518A2 (en) | 2003-06-04 |
| WO2002020045A3 (en) | 2002-10-31 |
| ATE450270T1 (de) | 2009-12-15 |
| IL154727A0 (en) | 2003-10-31 |
| ZA200301759B (en) | 2004-06-22 |
| ES2337653T3 (es) | 2010-04-28 |
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