JP2004506420A - 神経変性疾患のための診断剤としての鉄調節タンパク質−2(irp−2) - Google Patents

神経変性疾患のための診断剤としての鉄調節タンパク質−2(irp−2) Download PDF

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Publication number
JP2004506420A
JP2004506420A JP2002518256A JP2002518256A JP2004506420A JP 2004506420 A JP2004506420 A JP 2004506420A JP 2002518256 A JP2002518256 A JP 2002518256A JP 2002518256 A JP2002518256 A JP 2002518256A JP 2004506420 A JP2004506420 A JP 2004506420A
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irp
protein
mutant
antibody
wild
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JP2004506420A5 (enExample
Inventor
キルシュ ボルフ エム.
レナート アントン
ケルン ウェイン ジェイ.
カング デア−クヤング
レビン ロドニー エル.
ローアルト トレーシー エー
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Loma Linda University
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Loma Linda University
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Publication of JP2004506420A5 publication Critical patent/JP2004506420A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • General Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2002518256A 2000-08-04 2001-08-06 神経変性疾患のための診断剤としての鉄調節タンパク質−2(irp−2) Pending JP2004506420A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22286300P 2000-08-04 2000-08-04
PCT/US2001/024747 WO2002012284A2 (en) 2000-08-04 2001-08-06 Iron regulating protein-2 (irp-2) as a diagnostic for neurodegenerative disease

Publications (2)

Publication Number Publication Date
JP2004506420A true JP2004506420A (ja) 2004-03-04
JP2004506420A5 JP2004506420A5 (enExample) 2009-03-05

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ID=22834032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002518256A Pending JP2004506420A (ja) 2000-08-04 2001-08-06 神経変性疾患のための診断剤としての鉄調節タンパク質−2(irp−2)

Country Status (9)

Country Link
US (4) US20020165349A1 (enExample)
EP (1) EP1355933A2 (enExample)
JP (1) JP2004506420A (enExample)
CN (1) CN100535004C (enExample)
AU (1) AU2001284742A1 (enExample)
CA (1) CA2417310A1 (enExample)
MX (1) MXPA03000937A (enExample)
RU (1) RU2003105882A (enExample)
WO (1) WO2002012284A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
ATE404877T1 (de) * 2002-08-27 2008-08-15 Kennedy Krieger Inst Magnetische rezonanzbildgebung des mikrovaskulären blutvolumens
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
HRP20060073B1 (hr) 2003-07-23 2014-03-14 Bayer Healthcare Llc Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja
CN101010315A (zh) * 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
JP4653542B2 (ja) * 2005-04-06 2011-03-16 株式会社東芝 画像処理装置
CN100448481C (zh) * 2006-06-22 2009-01-07 中国科学院遗传与发育生物学研究所 xCT蛋白及其编码基因的新用途
WO2010068742A1 (en) * 2008-12-12 2010-06-17 Beckman Coulter, Inc. Multicolor flow cytometry compositions containing unconjugated phycobiliproteins
US8580230B2 (en) * 2009-02-23 2013-11-12 Kent State University Materials and methods for MRI contrast agents and drug delivery
EP2253716A1 (en) * 2009-05-15 2010-11-24 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Diagnostic methods for the prognosis of a brain tumor
EP2642289A1 (en) 2012-03-20 2013-09-25 Sensirion AG Portable electronic device
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
CN107636468A (zh) * 2015-04-02 2018-01-26 Crc心理健康有限公司 用于预测认知退化的风险的方法
WO2018148788A1 (en) * 2017-02-17 2018-08-23 Crc For Mental Health Ltd Method for predicting risk and rate of amyloid deposition and plaque formation
IT201700105483A1 (it) * 2017-09-21 2019-03-21 Braindtech S R L Metodo per la diagnosi e la prognosi di patologie neurodegenerative e neuroinfiammatorie
JP6737995B2 (ja) * 2018-11-29 2020-08-12 株式会社Resvo 精神疾患発症危険状態の診断用バイオマーカー
CN114446392B (zh) * 2022-01-21 2024-01-30 华东理工大学 确认蛋白质与核酸适配体结合时的关键精氨基酸残基位点的方法
CN114457067B (zh) * 2022-02-10 2024-10-25 中国科学院天津工业生物技术研究所 一种低成本快速去除dna合成中错误的方法
CN117417999B (zh) * 2023-11-27 2025-07-25 河南省人民医院 一种与ireb2基因相关的snp分子标记及其应用

Also Published As

Publication number Publication date
CA2417310A1 (en) 2002-02-14
WO2002012284A3 (en) 2003-08-21
WO2002012284A2 (en) 2002-02-14
MXPA03000937A (es) 2004-08-02
AU2001284742A1 (en) 2002-02-18
EP1355933A2 (en) 2003-10-29
US20050260669A1 (en) 2005-11-24
CN100535004C (zh) 2009-09-02
US20080020393A1 (en) 2008-01-24
US20020165349A1 (en) 2002-11-07
US20100041060A1 (en) 2010-02-18
RU2003105882A (ru) 2005-01-20
CN1556815A (zh) 2004-12-22

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