CN100535004C - 用作神经变性疾病诊断的铁调节蛋白-2 - Google Patents

用作神经变性疾病诊断的铁调节蛋白-2 Download PDF

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Publication number
CN100535004C
CN100535004C CNB018148549A CN01814854A CN100535004C CN 100535004 C CN100535004 C CN 100535004C CN B018148549 A CNB018148549 A CN B018148549A CN 01814854 A CN01814854 A CN 01814854A CN 100535004 C CN100535004 C CN 100535004C
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irp
gly
leu
protein
mutant
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Expired - Fee Related
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CNB018148549A
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English (en)
Chinese (zh)
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CN1556815A (zh
Inventor
W·M·克施
L·安顿
W·J·克林
D-K·康
R·L·勒温
T·A·洛瓦特
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Loma Linda University
US Department of Health and Human Services
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Loma Linda University
US Department of Health and Human Services
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Publication of CN1556815A publication Critical patent/CN1556815A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • General Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB018148549A 2000-08-04 2001-08-06 用作神经变性疾病诊断的铁调节蛋白-2 Expired - Fee Related CN100535004C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22286300P 2000-08-04 2000-08-04
US60/222,863 2000-08-04

Publications (2)

Publication Number Publication Date
CN1556815A CN1556815A (zh) 2004-12-22
CN100535004C true CN100535004C (zh) 2009-09-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018148549A Expired - Fee Related CN100535004C (zh) 2000-08-04 2001-08-06 用作神经变性疾病诊断的铁调节蛋白-2

Country Status (9)

Country Link
US (4) US20020165349A1 (enExample)
EP (1) EP1355933A2 (enExample)
JP (1) JP2004506420A (enExample)
CN (1) CN100535004C (enExample)
AU (1) AU2001284742A1 (enExample)
CA (1) CA2417310A1 (enExample)
MX (1) MXPA03000937A (enExample)
RU (1) RU2003105882A (enExample)
WO (1) WO2002012284A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
ATE404877T1 (de) * 2002-08-27 2008-08-15 Kennedy Krieger Inst Magnetische rezonanzbildgebung des mikrovaskulären blutvolumens
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
HRP20060073B1 (hr) 2003-07-23 2014-03-14 Bayer Healthcare Llc Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja
CN101010315A (zh) * 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
JP4653542B2 (ja) * 2005-04-06 2011-03-16 株式会社東芝 画像処理装置
CN100448481C (zh) * 2006-06-22 2009-01-07 中国科学院遗传与发育生物学研究所 xCT蛋白及其编码基因的新用途
WO2010068742A1 (en) * 2008-12-12 2010-06-17 Beckman Coulter, Inc. Multicolor flow cytometry compositions containing unconjugated phycobiliproteins
US8580230B2 (en) * 2009-02-23 2013-11-12 Kent State University Materials and methods for MRI contrast agents and drug delivery
EP2253716A1 (en) * 2009-05-15 2010-11-24 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Diagnostic methods for the prognosis of a brain tumor
EP2642289A1 (en) 2012-03-20 2013-09-25 Sensirion AG Portable electronic device
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
CN107636468A (zh) * 2015-04-02 2018-01-26 Crc心理健康有限公司 用于预测认知退化的风险的方法
WO2018148788A1 (en) * 2017-02-17 2018-08-23 Crc For Mental Health Ltd Method for predicting risk and rate of amyloid deposition and plaque formation
IT201700105483A1 (it) * 2017-09-21 2019-03-21 Braindtech S R L Metodo per la diagnosi e la prognosi di patologie neurodegenerative e neuroinfiammatorie
JP6737995B2 (ja) * 2018-11-29 2020-08-12 株式会社Ｒｅｓｖｏ 精神疾患発症危険状態の診断用バイオマーカー
CN114446392B (zh) * 2022-01-21 2024-01-30 华东理工大学 确认蛋白质与核酸适配体结合时的关键精氨基酸残基位点的方法
CN114457067B (zh) * 2022-02-10 2024-10-25 中国科学院天津工业生物技术研究所 一种低成本快速去除dna合成中错误的方法
CN117417999B (zh) * 2023-11-27 2025-07-25 河南省人民医院 一种与ireb2基因相关的snp分子标记及其应用

Also Published As

Publication number Publication date
CA2417310A1 (en) 2002-02-14
WO2002012284A3 (en) 2003-08-21
WO2002012284A2 (en) 2002-02-14
MXPA03000937A (es) 2004-08-02
JP2004506420A (ja) 2004-03-04
AU2001284742A1 (en) 2002-02-18
EP1355933A2 (en) 2003-10-29
US20050260669A1 (en) 2005-11-24
US20080020393A1 (en) 2008-01-24
US20020165349A1 (en) 2002-11-07
US20100041060A1 (en) 2010-02-18
RU2003105882A (ru) 2005-01-20
CN1556815A (zh) 2004-12-22

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Granted publication date: 20090902

Termination date: 20130806