|
US7364867B2
(en)
|
2000-04-17 |
2008-04-29 |
The Mount Sinai School Of Medicine |
Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
|
|
DE10215321A1
(de)
*
|
2002-04-02 |
2003-10-23 |
Metagen Pharmaceuticals Gmbh |
Trp-p8 Splice Varianten und regulatorische RNA
|
|
EP1497328A2
(en)
*
|
2002-04-16 |
2005-01-19 |
Bayer HealthCare AG |
Regulation of human transient receptor potential channel
|
|
JP2005538697A
(ja)
*
|
2002-04-19 |
2005-12-22 |
シエーリング アクチエンゲゼルシャフト |
新規前立腺腫瘍特異的プロモーター
|
|
AU2003261710B2
(en)
*
|
2003-01-08 |
2008-08-14 |
Nippon Milk Community Co., Ltd. |
Human calcium transporter 1 gene, screening method of calcium absorption regulating factor, and calcium absorption regulating factor
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
WO2007053570A2
(en)
*
|
2005-10-31 |
2007-05-10 |
Janssen Pharmaceutica N.V. |
A polypeptide complex of trpm8 and calmodulin and its uses thereof
|
|
JP5749154B2
(ja)
*
|
2008-03-19 |
2015-07-15 |
ソリシメド・バイオファーマ・インコーポレーテッド |
Ｔｒｐｖ６カルシウムチャネル活性阻害による癌治療のためのペプチド組成物
|
|
EP2445932B1
(en)
|
2009-06-26 |
2018-02-28 |
Soricimed Biopharma Inc. |
Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery
|
|
JP2013504585A
(ja)
|
2009-09-09 |
2013-02-07 |
セントローズ， エルエルシー |
細胞外標的化薬物複合体
|
|
SI2528625T1
(sl)
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
CA2799540A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
US20120121615A1
(en)
|
2010-11-17 |
2012-05-17 |
Flygare John A |
Alaninyl maytansinol antibody conjugates
|
|
US8679767B2
(en)
|
2011-05-12 |
2014-03-25 |
Genentech, Inc. |
Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
|
|
BR112014009050B1
(pt)
|
2011-10-14 |
2022-06-21 |
Medimmune Limited |
Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas
|
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
|
MX338711B
(es)
|
2012-10-12 |
2016-04-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
RS57694B1
(sr)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin - anti-psma konjugati antitela
|
|
HRP20182129T1
(hr)
|
2012-10-12 |
2019-02-08 |
Adc Therapeutics Sa |
Konjugati protutijelo - pirolobenzodiazepin
|
|
EP2906296B1
(en)
|
2012-10-12 |
2018-03-21 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
|
JP6392765B2
(ja)
|
2012-10-12 |
2018-09-19 |
エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ |
ピロロベンゾジアゼピン−抗体結合体
|
|
EP2906297B1
(en)
|
2012-10-12 |
2017-12-06 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
CN110627797A
(zh)
|
2012-12-21 |
2019-12-31 |
麦迪穆有限责任公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
KR102189659B1
(ko)
|
2013-02-28 |
2020-12-11 |
가부시키가이샤 니찌레이 바이오사이언스 |
표지 효소를 사용한 염색용 dab 함유 기질 키트
|
|
MX362970B
(es)
|
2013-03-13 |
2019-02-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
AU2014229529B2
(en)
|
2013-03-13 |
2018-02-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
TWI680766B
(zh)
|
2013-03-13 |
2020-01-01 |
英商梅迪繆思有限公司 |
吡咯并苯并二氮呯及其共軛物
|
|
BR112016002829A2
(pt)
|
2013-08-12 |
2017-09-19 |
Genentech Inc |
Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi
|
|
WO2015052534A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2015052535A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2015095227A2
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
|
EP3082876B1
(en)
|
2013-12-16 |
2018-01-17 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
|
JP6671292B2
(ja)
|
2013-12-16 |
2020-03-25 |
ジェネンテック， インコーポレイテッド |
ペプチド模倣化合物及びその抗体−薬物コンジュゲート
|
|
EP3193940A1
(en)
|
2014-09-10 |
2017-07-26 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2016040825A1
(en)
|
2014-09-12 |
2016-03-17 |
Genentech, Inc. |
Anthracycline disulfide intermediates, antibody-drug conjugates and methods
|
|
SG11201701128YA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Cysteine engineered antibodies and conjugates
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CN107073136A
(zh)
|
2014-09-17 |
2017-08-18 |
健泰科生物技术公司 |
吡咯并苯并二氮杂卓及其抗体二硫化物偶联物
|
|
CN107148285B
(zh)
|
2014-11-25 |
2022-01-04 |
Adc治疗股份有限公司 |
吡咯并苯并二氮杂䓬-抗体缀合物
|
|
AU2015358532C1
(en)
|
2014-12-03 |
2020-10-29 |
Genentech, Inc. |
Quaternary amine compounds and antibody-drug conjugates thereof
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
CR20180243A
(es)
|
2015-10-02 |
2018-07-31 |
Genentech Inc |
Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
EP3365025B1
(en)
|
2015-10-20 |
2020-07-15 |
Genentech, Inc. |
Calicheamicin-antibody-drug conjugates and methods of use
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
CN108700598A
(zh)
|
2016-03-25 |
2018-10-23 |
豪夫迈·罗氏有限公司 |
多路总抗体和抗体缀合的药物量化测定法
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
CN118436801A
(zh)
|
2016-05-20 |
2024-08-06 |
豪夫迈·罗氏有限公司 |
Protac抗体缀合物及其使用方法
|
|
EP3465221B1
(en)
|
2016-05-27 |
2020-07-22 |
H. Hoffnabb-La Roche Ag |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
|
WO2017214024A1
(en)
|
2016-06-06 |
2017-12-14 |
Genentech, Inc. |
Silvestrol antibody-drug conjugates and methods of use
|
|
CN109689111B
(zh)
|
2016-08-11 |
2024-04-05 |
基因泰克公司 |
吡咯并苯并二氮杂䓬前药及其抗体缀合物
|
|
JP7050770B2
(ja)
|
2016-10-05 |
2022-04-08 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
抗体薬物コンジュゲートの調製方法
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
RS61795B1
(sr)
|
2017-02-08 |
2021-06-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin antitela
|
|
CN110582505B
(zh)
|
2017-04-18 |
2021-04-02 |
免疫医疗有限公司 |
吡咯并苯并二氮杂*缀合物
|
|
WO2018193102A1
(en)
|
2017-04-20 |
2018-10-25 |
Adc Therapeutics Sa |
Combination therapy with an anti-axl antibody-drug conjugate
|
|
CA3064804A1
(en)
|
2017-06-14 |
2018-12-20 |
Adc Therapeutics Sa |
Dosage regimes for the administration of an anti-cd19 adc
|
|
KR102270107B1
(ko)
|
2017-08-18 |
2021-06-30 |
메디뮨 리미티드 |
피롤로벤조디아제핀 컨쥬게이트
|
|
EP3684773B1
(en)
|
2017-09-20 |
2026-04-29 |
pH Pharma Co., Ltd. |
Thailanstatin analogs
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
|
EP3867267A1
(en)
*
|
2018-10-18 |
2021-08-25 |
FundaMental Pharma GmbH |
Novel means to modulate nmda receptor-mediated toxicity
|
|
JP7708662B2
(ja)
|
2018-10-24 |
2025-07-15 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
コンジュゲート化された化学的分解誘導物質および使用方法
|
|
JP2022513198A
(ja)
|
2018-12-10 |
2022-02-07 |
ジェネンテック， インコーポレイテッド |
Ｆｃ含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド
|
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
|
CN113631560B
(zh)
|
2019-03-15 |
2025-02-18 |
麦迪穆有限责任公司 |
氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
|
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
|
EP4426727A2
(en)
|
2021-11-03 |
2024-09-11 |
Hangzhou Dac Biotech Co., Ltd. |
Specific conjugation of an antibody
|
|
WO2024138128A2
(en)
|
2022-12-23 |
2024-06-27 |
Genentech, Inc. |
Cereblon degrader conjugates, and uses thereof
|
|
KR20260012304A
(ko)
|
2023-04-17 |
2026-01-26 |
피크 바이오, 인크. |
항체 및 항체-약물 접합체 및 사용 방법 및 합성 공정 및 중간체
|
|
WO2026006689A2
(en)
|
2024-06-28 |
2026-01-02 |
Firefly Bio, Inc. |
Bcl-xl degrader antibody conjugates and uses thereof
|
|
WO2026006688A2
(en)
|
2024-06-28 |
2026-01-02 |
Firefly Bio, Inc. |
Degrader antibody conjugates and uses thereof
|