|
US7364867B2
(en)
|
2000-04-17 |
2008-04-29 |
The Mount Sinai School Of Medicine |
Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
|
|
DE10215321A1
(de)
*
|
2002-04-02 |
2003-10-23 |
Metagen Pharmaceuticals Gmbh |
Trp-p8 Splice Varianten und regulatorische RNA
|
|
EP1497328A2
(en)
*
|
2002-04-16 |
2005-01-19 |
Bayer HealthCare AG |
Regulation of human transient receptor potential channel
|
|
EP1578926A4
(en)
*
|
2002-04-19 |
2006-11-02 |
Schering Ag |
NEW PROMOTER SPECIFIC TO PROSTATIC TUMOR
|
|
US20070037149A1
(en)
*
|
2003-01-08 |
2007-02-15 |
Makoto Shimizu |
Human calcium transporter 1 gene, screening method of calcium absorption regulating factor, and calcium absorption regulating factor
|
|
NZ583292A
(en)
|
2003-11-06 |
2012-03-30 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
MXPA06014065A
(es)
|
2004-06-01 |
2007-01-31 |
Genentech Inc |
Conjugados de droga-anticuerpo y metodos.
|
|
ES2579805T3
(es)
|
2004-09-23 |
2016-08-16 |
Genentech, Inc. |
Anticuerpos y conjugados modificados por ingeniería genética con cisteína
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
AU2006308863A1
(en)
|
2005-10-31 |
2007-05-10 |
Janssen Pharmaceutica N.V. |
A polypeptide complex of TRPM8 and calmodulin and its uses thereof
|
|
ES2530091T3
(es)
|
2008-03-19 |
2015-02-26 |
Soricimed Biopharma Inc. |
Composiciones peptídicas para el tratamiento del cáncer por la inhibición de la actividad del canal de calcio TRPV6
|
|
EP2445932B1
(en)
|
2009-06-26 |
2018-02-28 |
Soricimed Biopharma Inc. |
Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery
|
|
CA2809819A1
(en)
|
2009-09-09 |
2011-03-17 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
US20110256157A1
(en)
|
2010-04-15 |
2011-10-20 |
Spirogen Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
JP2013534520A
(ja)
|
2010-06-08 |
2013-09-05 |
ジェネンテック， インコーポレイテッド |
システイン操作抗体及びコンジュゲート
|
|
ES2544608T3
(es)
|
2010-11-17 |
2015-09-02 |
Genentech, Inc. |
Conjugados de anticuerpo y de alaninil-maitansinol
|
|
CA2833212C
(en)
|
2011-05-12 |
2020-06-09 |
Genentech, Inc. |
Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides
|
|
HRP20151374T1
(hr)
|
2011-10-14 |
2016-01-15 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
|
LT2906251T
(lt)
|
2012-10-12 |
2017-12-11 |
Adc Therapeutics Sa |
Pirolobenzodiazepino-anti-cd22 antikūno konjugatai
|
|
HUE045435T2
(hu)
|
2012-10-12 |
2019-12-30 |
Medimmune Ltd |
Pirrolobenzodiazepinek és konjugátumaik
|
|
JP6392764B2
(ja)
|
2012-10-12 |
2018-09-19 |
エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ |
ピロロベンゾジアゼピン−抗体結合体
|
|
HRP20182129T1
(hr)
|
2012-10-12 |
2019-02-08 |
Adc Therapeutics Sa |
Konjugati protutijelo - pirolobenzodiazepin
|
|
JP6270859B2
(ja)
|
2012-10-12 |
2018-01-31 |
エイディーシー・セラピューティクス・エス・アー・エール・エルＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａｒｌ |
ピロロベンゾジアゼピン−抗体結合体
|
|
EP2906297B1
(en)
|
2012-10-12 |
2017-12-06 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP2906250B1
(en)
|
2012-10-12 |
2018-05-30 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-anti-psma antibody conjugates
|
|
AU2013366493B2
(en)
|
2012-12-21 |
2017-08-24 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
US9567340B2
(en)
|
2012-12-21 |
2017-02-14 |
Medimmune Limited |
Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
|
|
US20160010140A1
(en)
|
2013-02-28 |
2016-01-14 |
Nichirei Biosciences, Inc. |
Dab-containing substrate kit for dyeing use which is produced using labelling enzyme
|
|
JP6444902B2
(ja)
|
2013-03-13 |
2018-12-26 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ピロロベンゾジアゼピン及びその結合体
|
|
CA2904044C
(en)
|
2013-03-13 |
2020-03-31 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CN105307685B
(zh)
|
2013-03-13 |
2019-03-08 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓和其结合物
|
|
MX2016001862A
(es)
|
2013-08-12 |
2016-08-03 |
Genentech Inc |
Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo[e]indol, y metodos de uso y tratamiento.
|
|
WO2015052532A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US9950078B2
(en)
|
2013-10-11 |
2018-04-24 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US9956299B2
(en)
|
2013-10-11 |
2018-05-01 |
Medimmune Limited |
Pyrrolobenzodiazepine—antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP3082874A2
(en)
|
2013-12-16 |
2016-10-26 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
|
AU2014364927A1
(en)
|
2013-12-16 |
2016-07-07 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
|
JP6980384B2
(ja)
|
2013-12-16 |
2021-12-15 |
ジェネンテック， インコーポレイテッド |
１−（クロロメチル）−２，３−ジヒドロ−１ｈ−ベンゾ［ｅ］インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法
|
|
JP6531166B2
(ja)
|
2014-09-10 |
2019-06-12 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ピロロベンゾジアゼピン及びそのコンジュゲート
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
AU2015314826A1
(en)
|
2014-09-12 |
2017-03-02 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
JP6622293B2
(ja)
|
2014-09-12 |
2019-12-18 |
ジェネンテック， インコーポレイテッド |
アントラサイクリンジスルフィド中間体、抗体−薬物複合体、及び方法
|
|
CA2959689A1
(en)
|
2014-09-17 |
2016-03-24 |
Genentech, Inc. |
Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
|
|
EP3223854A1
(en)
|
2014-11-25 |
2017-10-04 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
KR20170086121A
(ko)
|
2014-12-03 |
2017-07-25 |
제넨테크, 인크. |
4급 아민 화합물 및 그의 항체-약물 접합체
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
MA43345A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
MA45326A
(fr)
|
2015-10-20 |
2018-08-29 |
Genentech Inc |
Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
EP3433621A1
(en)
|
2016-03-25 |
2019-01-30 |
H. Hoffnabb-La Roche Ag |
Multiplexed total antibody and antibody-conjugated drug quantification assay
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
PL3458101T3
(pl)
|
2016-05-20 |
2021-05-31 |
F. Hoffmann-La Roche Ag |
Koniugaty PROTAC-przeciwciało i sposoby ich stosowania
|
|
WO2017205741A1
(en)
|
2016-05-27 |
2017-11-30 |
Genentech, Inc. |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
|
CN109476648B
(zh)
|
2016-06-06 |
2022-09-13 |
豪夫迈·罗氏有限公司 |
司维司群抗体-药物缀合物和使用方法
|
|
EP3496763A1
(en)
|
2016-08-11 |
2019-06-19 |
Genentech, Inc. |
Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
|
|
EP3522933B1
(en)
|
2016-10-05 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Methods for preparing antibody drug conjugates
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
KR20200032243A
(ko)
|
2017-02-08 |
2020-03-25 |
에이디씨 테라퓨틱스 에스에이 |
피롤로벤조디아제핀-항체 컨주게이트
|
|
SI3612537T1
(sl)
|
2017-04-18 |
2022-10-28 |
Medimmune Limited |
Konjugati pirolobenzodiazepina
|
|
EP3612234B1
(en)
|
2017-04-20 |
2024-03-13 |
ADC Therapeutics SA |
Combination therapy with an anti-axl antibody-drug conjugate
|
|
KR102442736B1
(ko)
|
2017-06-14 |
2022-09-16 |
에이디씨 테라퓨틱스 에스에이 |
항-cd19 adc의 투여를 위한 투약량 체제
|
|
CN111065638B
(zh)
|
2017-08-18 |
2021-04-09 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂䓬缀合物
|
|
CN111788208B
(zh)
|
2017-09-20 |
2023-11-24 |
Ph制药有限公司 |
泰兰他汀类似物
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
|
CN112867731A
(zh)
*
|
2018-10-18 |
2021-05-28 |
基本制药有限公司 |
调节nmda受体介导的毒性的新方法
|
|
AU2019365238A1
(en)
|
2018-10-24 |
2021-05-13 |
F. Hoffmann-La Roche Ag |
Conjugated chemical inducers of degradation and methods of use
|
|
WO2020123275A1
(en)
|
2018-12-10 |
2020-06-18 |
Genentech, Inc. |
Photocrosslinking peptides for site specific conjugation to fc-containing proteins
|
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
|
IL286326B2
(en)
|
2019-03-15 |
2025-10-01 |
Medimmune Ltd |
Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer
|
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
|
CA3236930A1
(en)
|
2021-11-03 |
2022-04-21 |
Hangzhou Dac Biotech Co., Ltd. |
Specific conjugation of an antibody
|
|
TW202432187A
(zh)
|
2022-12-23 |
2024-08-16 |
美商建南德克公司 |
小腦蛋白降解劑結合物及其用途
|
|
AU2024257248A1
(en)
|
2023-04-17 |
2025-11-06 |
Peak Bio, Inc. |
Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates
|