JP2004504320A5 - - Google Patents
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- Publication number
- JP2004504320A5 JP2004504320A5 JP2002512179A JP2002512179A JP2004504320A5 JP 2004504320 A5 JP2004504320 A5 JP 2004504320A5 JP 2002512179 A JP2002512179 A JP 2002512179A JP 2002512179 A JP2002512179 A JP 2002512179A JP 2004504320 A5 JP2004504320 A5 JP 2004504320A5
- Authority
- JP
- Japan
- Prior art keywords
- motomeko
- compound according
- beta
- receptor agonist
- obesity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21796500P | 2000-07-13 | 2000-07-13 | |
| US60/217,965 | 2000-07-13 | ||
| US24161400P | 2000-10-19 | 2000-10-19 | |
| US60/241,614 | 2000-10-19 | ||
| US29298801P | 2001-05-23 | 2001-05-23 | |
| US60/292,988 | 2001-05-23 | ||
| PCT/US2001/016519 WO2002006276A1 (en) | 2000-07-13 | 2001-07-09 | Beta3 adrenergic agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004504320A JP2004504320A (ja) | 2004-02-12 |
| JP2004504320A5 true JP2004504320A5 (OSRAM) | 2008-08-21 |
| JP4988128B2 JP4988128B2 (ja) | 2012-08-01 |
Family
ID=27396478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002512179A Expired - Lifetime JP4988128B2 (ja) | 2000-07-13 | 2001-07-09 | β３アドレナリン作動性アゴニスト |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6730792B2 (OSRAM) |
| EP (1) | EP1303509B1 (OSRAM) |
| JP (1) | JP4988128B2 (OSRAM) |
| KR (1) | KR20030016396A (OSRAM) |
| CN (1) | CN1441800A (OSRAM) |
| AU (1) | AU2001272917A1 (OSRAM) |
| BR (1) | BR0112409A (OSRAM) |
| CA (1) | CA2415331A1 (OSRAM) |
| CZ (1) | CZ2003106A3 (OSRAM) |
| DK (1) | DK1303509T3 (OSRAM) |
| EA (1) | EA200300145A1 (OSRAM) |
| ES (1) | ES2398097T3 (OSRAM) |
| HR (1) | HRP20030018A2 (OSRAM) |
| HU (1) | HUP0301329A2 (OSRAM) |
| IL (2) | IL152528A0 (OSRAM) |
| MX (1) | MXPA03000308A (OSRAM) |
| NO (1) | NO20030098D0 (OSRAM) |
| PE (1) | PE20020195A1 (OSRAM) |
| PL (1) | PL360098A1 (OSRAM) |
| PT (1) | PT1303509E (OSRAM) |
| SK (1) | SK632003A3 (OSRAM) |
| SV (1) | SV2002000522A (OSRAM) |
| WO (1) | WO2002006276A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1303509T3 (da) * | 2000-07-13 | 2013-01-02 | Lilly Co Eli | Beta3 adrenerge agonister |
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| US7208505B2 (en) * | 2001-08-14 | 2007-04-24 | Eli Lilly And Company | β3 adrenergic agonists |
| US6911463B2 (en) | 2001-08-14 | 2005-06-28 | Eli Lilly And Company | 3-substituted oxindole β-3 agonists |
| SE0103325D0 (sv) | 2001-10-04 | 2001-10-04 | Astrazeneca Ab | Novel compounds |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| JP2005514366A (ja) | 2001-11-20 | 2005-05-19 | イーライ・リリー・アンド・カンパニー | ３−置換オキシインドールβ３アゴニスト |
| DE60225174T2 (de) | 2001-11-20 | 2009-02-12 | Eli Lilly And Co., Indianapolis | Beta-3 adrenergische agonisten |
| US7009060B2 (en) | 2002-01-11 | 2006-03-07 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists |
| WO2003068744A1 (en) * | 2002-02-18 | 2003-08-21 | Ishihara Sangyo Kaisha, Ltd. | Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same |
| ES2305491T3 (es) * | 2002-09-19 | 2008-11-01 | Eli Lilly And Company | Eteres de diarilo como antagonistas de receptores de opioides. |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| EP1778638A1 (en) | 2004-07-21 | 2007-05-02 | Theravance, Inc. | Diaryl ether beta2 adrenergic receptor agonists |
| EP2064199A1 (en) | 2006-09-08 | 2009-06-03 | Pfizer Products Inc. | Diaryl ether derivatives and uses thereof |
| EP1947103A1 (en) | 2007-01-22 | 2008-07-23 | 4Sc Ag | Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments |
| CN103265501B (zh) * | 2007-03-27 | 2015-06-03 | 盐野义制药株式会社 | N-苯基-n’-苯磺酰基哌嗪衍生物的制造方法 |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| US9718816B2 (en) | 2013-03-15 | 2017-08-01 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof |
| EA201591532A1 (ru) | 2013-03-15 | 2016-03-31 | Эпизим, Инк. | Ингибиторы carm1 и их применение |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| CA2996879C (en) * | 2015-10-05 | 2020-04-21 | Elanco Us Inc. | Methods and formulations for reducing ammonia emissions from bovines |
| CN112255349A (zh) * | 2020-10-14 | 2021-01-22 | 青岛天祥食品集团有限公司 | 一种检测食用植物油中缩水甘油及缩水甘油酯的快速检测方法 |
| CN114380811A (zh) * | 2021-12-29 | 2022-04-22 | 天和药业股份有限公司 | 一种卢巴贝隆的合成方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6010021B2 (ja) * | 1979-01-31 | 1985-03-14 | 田辺製薬株式会社 | 新規ベンジルアルコ−ル誘導体及びその製法 |
| JPS5724375A (en) * | 1980-07-21 | 1982-02-08 | Shionogi & Co Ltd | Isoxazolyl-aminopropoxybenzene derivative |
| JPS58164583A (ja) * | 1982-03-18 | 1983-09-29 | Nippon Shinyaku Co Ltd | フエノキシプロパノ−ルアミン誘導体 |
| EP0096006A3 (de) * | 1982-05-28 | 1984-12-19 | Ciba-Geigy Ag | 3-(Ureidocyclohexylamino)-propan-1,2-diolderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung |
| DE3423429A1 (de) * | 1984-06-26 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Substituierte phenoxyalkylaminopropanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
| DE3426419A1 (de) * | 1984-07-18 | 1986-01-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| GB8528633D0 (en) * | 1985-11-21 | 1985-12-24 | Beecham Group Plc | Compounds |
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| US5480908A (en) * | 1993-12-13 | 1996-01-02 | American Cyanamid Company | β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions |
| IL113084A (en) * | 1994-03-23 | 1999-01-26 | Sankyo Co | Thiazolidine and oxazolidine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| IL113410A (en) * | 1994-04-26 | 1999-11-30 | Merck & Co Inc | Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them |
| WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| AU7692696A (en) | 1995-12-01 | 1997-06-27 | Novartis Ag | Heteroaryl derivatives |
| WO1997020820A1 (en) | 1995-12-01 | 1997-06-12 | Novartis Ag | Heteroaryl compounds |
| WO1997019682A1 (en) | 1995-12-01 | 1997-06-05 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
| WO1997020822A1 (en) | 1995-12-01 | 1997-06-12 | Novartis Ag | Quinazolin-2,4-diazirines as npy receptor antagonist |
| AU7692996A (en) | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| JP2000504021A (ja) | 1996-02-02 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 糖尿病及び関連疾患状態を治療する方法 |
| JP2002503203A (ja) | 1996-02-02 | 2002-01-29 | メルク エンド カンパニー インコーポレーテッド | 抗糖尿病薬及び抗肥満症薬としての複素環誘導体 |
| JP2002515865A (ja) | 1996-02-02 | 2002-05-28 | メルク エンド カンパニー インコーポレーテッド | 抗糖尿病薬 |
| WO1997028115A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Antidiabetic agents |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| JP2000511903A (ja) * | 1996-06-07 | 2000-09-12 | メルク エンド カンパニー インコーポレーテッド | 糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド |
| US5808080A (en) * | 1996-09-05 | 1998-09-15 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| ES2171839T3 (es) | 1996-09-05 | 2002-09-16 | Lilly Co Eli | Analogos de carbazol como agonistas adrenergicos selectivos de beta3. |
| US6011048A (en) * | 1997-01-28 | 2000-01-04 | Merck & Co., Inc. | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity |
| WO1998032753A1 (en) | 1997-01-28 | 1998-07-30 | Merck & Co., Inc. | THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY |
| AU751015B2 (en) * | 1997-12-19 | 2002-08-08 | Bayer Corporation | Novel sulfonamide substituted chroman derivatives useful as beta-3 adrenoreceptor agonists |
| FR2780057B1 (fr) * | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AUPP796798A0 (en) | 1998-12-30 | 1999-01-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| DK1303509T3 (da) * | 2000-07-13 | 2013-01-02 | Lilly Co Eli | Beta3 adrenerge agonister |
-
2001
- 2001-07-09 DK DK01952125.1T patent/DK1303509T3/da active
- 2001-07-09 PE PE2001000679A patent/PE20020195A1/es not_active Application Discontinuation
- 2001-07-09 EP EP01952125A patent/EP1303509B1/en not_active Expired - Lifetime
- 2001-07-09 CN CN01812754A patent/CN1441800A/zh active Pending
- 2001-07-09 JP JP2002512179A patent/JP4988128B2/ja not_active Expired - Lifetime
- 2001-07-09 PT PT1952125T patent/PT1303509E/pt unknown
- 2001-07-09 CA CA002415331A patent/CA2415331A1/en not_active Abandoned
- 2001-07-09 US US10/311,112 patent/US6730792B2/en not_active Expired - Lifetime
- 2001-07-09 SK SK63-2003A patent/SK632003A3/sk unknown
- 2001-07-09 AU AU2001272917A patent/AU2001272917A1/en not_active Abandoned
- 2001-07-09 EA EA200300145A patent/EA200300145A1/ru unknown
- 2001-07-09 HU HU0301329A patent/HUP0301329A2/hu unknown
- 2001-07-09 IL IL15252801A patent/IL152528A0/xx unknown
- 2001-07-09 MX MXPA03000308A patent/MXPA03000308A/es unknown
- 2001-07-09 BR BR0112409-9A patent/BR0112409A/pt not_active Application Discontinuation
- 2001-07-09 PL PL36009801A patent/PL360098A1/xx not_active Application Discontinuation
- 2001-07-09 KR KR10-2003-7000447A patent/KR20030016396A/ko not_active Ceased
- 2001-07-09 SV SV2001000522A patent/SV2002000522A/es not_active Application Discontinuation
- 2001-07-09 CZ CZ2003106A patent/CZ2003106A3/cs unknown
- 2001-07-09 ES ES01952125T patent/ES2398097T3/es not_active Expired - Lifetime
- 2001-07-09 HR HR20030018A patent/HRP20030018A2/hr not_active Application Discontinuation
- 2001-07-09 WO PCT/US2001/016519 patent/WO2002006276A1/en not_active Ceased
-
2002
- 2002-10-28 IL IL152528A patent/IL152528A/en active IP Right Grant
-
2003
- 2003-01-09 NO NO20030098A patent/NO20030098D0/no unknown
-
2004
- 2004-05-04 US US10/838,904 patent/US20040242633A1/en not_active Abandoned
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