JP2004502739A5 - - Google Patents

Info

Publication number

JP2004502739A5

JP2004502739A5 JP2002508462A JP2002508462A JP2004502739A5 JP 2004502739 A5 JP2004502739 A5 JP 2004502739A5 JP 2002508462 A JP2002508462 A JP 2002508462A JP 2002508462 A JP2002508462 A JP 2002508462A JP 2004502739 A5 JP2004502739 A5 JP 2004502739A5

Authority

JP

Japan

Prior art keywords

gly

asp

peptide

ala

glu

Prior art date

2001-07-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 21
• 239000000203 mixture Substances 0.000 claims 17
• 239000003869 thrombin derivative Substances 0.000 claims 14
• 230000002491 angiogenic effect Effects 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 150000001413 amino acids Chemical group 0.000 claims 4
• 210000005003 heart tissue Anatomy 0.000 claims 4
• 108020002447 serine esterase Proteins 0.000 claims 4
• 102000005428 serine esterase Human genes 0.000 claims 4
• 108091036078 conserved sequence Proteins 0.000 claims 3
• HZKLCOYAVAAQRD-VGMNWLOBSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1r)-1-carboxyethyl]amino]-4-oxobutanoic acid Chemical compound OC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N HZKLCOYAVAAQRD-VGMNWLOBSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• IEHDJWSAXBGJIP-RYUDHWBXSA-N Phe-Val Chemical compound CC(C)[C@@H](C([O-])=O)NC(=O)[C@@H]([NH3+])CC1=CC=CC=C1 IEHDJWSAXBGJIP-RYUDHWBXSA-N 0.000 claims 2
• 102000003790 Thrombin receptors Human genes 0.000 claims 2
• 108090000166 Thrombin receptors Proteins 0.000 claims 2
• 238000002399 angioplasty Methods 0.000 claims 2
• 108010086780 arginyl-glycyl-aspartyl-alanine Proteins 0.000 claims 2
• 210000004204 blood vessel Anatomy 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 239000003405 delayed action preparation Substances 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 108010084572 phenylalanyl-valine Proteins 0.000 claims 2
• 230000004936 stimulating effect Effects 0.000 claims 2
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 206010053648 Vascular occlusion Diseases 0.000 claims 1
• 238000007675 cardiac surgery Methods 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 239000011859 microparticle Substances 0.000 claims 1
• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
• 239000004633 polyglycolic acid Substances 0.000 claims 1
• 239000004626 polylactic acid Substances 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 230000008929 regeneration Effects 0.000 claims 1
• 238000011069 regeneration method Methods 0.000 claims 1
• 208000037803 restenosis Diseases 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1
• 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
• 208000021331 vascular occlusion disease Diseases 0.000 claims 1