JP3618736B2 - トロンビン由来ペプチドを使用した治療法 - Google Patents

トロンビン由来ペプチドを使用した治療法 Download PDF

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Publication number
JP3618736B2
JP3618736B2 JP2002508462A JP2002508462A JP3618736B2 JP 3618736 B2 JP3618736 B2 JP 3618736B2 JP 2002508462 A JP2002508462 A JP 2002508462A JP 2002508462 A JP2002508462 A JP 2002508462A JP 3618736 B2 JP3618736 B2 JP 3618736B2
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Japanese (ja)
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JP2004502739A (ja
JP2004502739A5 (enExample
Inventor
カーニー，ダレル，エイチ．
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ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
JP2002508462A 2000-07-12 2001-07-12 トロンビン由来ペプチドを使用した治療法 Expired - Fee Related JP3618736B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21758300P 2000-07-12 2000-07-12
PCT/US2001/021944 WO2002004008A2 (en) 2000-07-12 2001-07-12 Methods of therapy with thrombin derived peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004232356A Division JP2005036007A (ja) 2000-07-12 2004-08-09 トロンビン由来ペプチドを使用した治療法

Publications (3)

Publication Number Publication Date
JP2004502739A JP2004502739A (ja) 2004-01-29
JP2004502739A5 JP2004502739A5 (enExample) 2005-01-06
JP3618736B2 true JP3618736B2 (ja) 2005-02-09

Family

ID=22811661

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002508462A Expired - Fee Related JP3618736B2 (ja) 2000-07-12 2001-07-12 トロンビン由来ペプチドを使用した治療法
JP2004232356A Withdrawn JP2005036007A (ja) 2000-07-12 2004-08-09 トロンビン由来ペプチドを使用した治療法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004232356A Withdrawn JP2005036007A (ja) 2000-07-12 2004-08-09 トロンビン由来ペプチドを使用した治療法

Country Status (10)

Country Link
US (5) US6867190B2 (enExample)
EP (1) EP1253937B1 (enExample)
JP (2) JP3618736B2 (enExample)
CN (1) CN100500211C (enExample)
AT (1) ATE249238T1 (enExample)
AU (2) AU7890701A (enExample)
CA (1) CA2415778A1 (enExample)
DE (2) DE60100740T4 (enExample)
TW (1) TWI257307B (enExample)
WO (1) WO2002004008A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
AU2002241917B2 (en) * 2000-07-12 2006-06-15 The Board Of Regents, The University Of Texas System Thrombin derived peptides for promoting cardiac tissue repair
TWI257307B (en) * 2000-07-12 2006-07-01 Orthologic Corp Pharmaceutical composition for cardiac tissue repair
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
JP4205592B2 (ja) * 2002-01-16 2009-01-07 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 心臓組織修復を促進するためのトロンビン由来ペプチド
ATE362939T1 (de) * 2002-07-02 2007-06-15 Orthologic Corp Dimere von thrombinpeptidderivaten
EP1539214A4 (en) * 2002-07-02 2008-01-02 Orthologic Corp Thrombin
AU2003256540B2 (en) * 2002-07-12 2008-12-11 Cook Medical Technologies Llc Coated medical device
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
US7381861B2 (en) 2003-02-12 2008-06-03 Monsanto Technology Llc Cotton event MON 88913 and compositions and methods for detection thereof
US7641643B2 (en) * 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
PL1559431T3 (pl) * 2003-12-31 2007-10-31 Orthologic Corp Kompozycja farmaceutyczna dla pochodnych peptydu trombiny
CA2576971A1 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
JP2006321740A (ja) * 2005-05-18 2006-11-30 Kanazawa Univ 虚血後血管新生促進剤
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8334259B2 (en) 2006-09-22 2012-12-18 The Board Of Regents, The University Of Texas System Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8227412B2 (en) * 2007-03-29 2012-07-24 Tsopanoglou Nikos E Bioactive parstatin peptides and methods of use
US20100303793A1 (en) * 2007-04-10 2010-12-02 The Board Of Regents, The University Of Texas Syst Combination therapy for cardiac revascularization and cardiac repair
US8202528B2 (en) * 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
GB2450747A (en) * 2007-07-06 2009-01-07 Univ Sheffield Treatment of sensorineural hearing loss
US8586398B2 (en) * 2008-01-18 2013-11-19 Miasole Sodium-incorporation in solar cell substrates and contacts
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
CA2719940A1 (en) * 2008-03-26 2009-11-26 Orthologic Corp. Methods for treating acute myocardial infarction
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
US20110117075A1 (en) * 2008-03-26 2011-05-19 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
WO2010033862A2 (en) * 2008-09-19 2010-03-25 The Board Of Regents, The University Of Texas System Methods for treating cancer
US20130101574A1 (en) * 2010-06-11 2013-04-25 Darrell H. Carney Methods of using thrombin peptide derivatives
GB201314312D0 (en) * 2013-08-09 2013-09-25 Regentec Ltd Composition and delivery system
US9321812B2 (en) 2014-03-28 2016-04-26 Perle Bioscience Insulin independence among patients with diabetes utilizing an optimized hamster REG3 gamma peptide
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma
WO2020210087A1 (en) * 2019-04-12 2020-10-15 Affirmed Pharma, Llc Rusalatide acetate compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352664A (en) 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
US5244460A (en) * 1991-11-27 1993-09-14 The United States Of America As Represented By The Department Of Health And Human Services Method to foster myocardial blood vessel growth and improve blood flow to the heart
JPH08508511A (ja) 1993-04-29 1996-09-10 ワシントン・ユニバーシテイー 副行循環の改善への血小板由来成長因子の使用
EP0867450B1 (en) * 1995-10-24 2004-08-11 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute TFPI-related Peptides which inhibit growth of smooth muscle cells
US5912229A (en) * 1996-03-01 1999-06-15 Novo Nordisk Als Use of a pharmaceutical composition comprising an appetite-suppressing peptide
US6197751B1 (en) * 1997-11-10 2001-03-06 The United States Of America As Represented By The Department Of Health And Human Services Thymosin α1 promotes tissue repair, angiogenesis and cell migration
US6033436A (en) * 1998-02-17 2000-03-07 Md3, Inc. Expandable stent
JP2002512200A (ja) 1998-04-17 2002-04-23 アンジオジェニックス， インコーポレイテッド 治療的な脈管形成因子およびその使用方法
WO2000024412A2 (en) 1998-10-26 2000-05-04 Ludwig Institute For Cancer Research Use of vegf-c or vegf-d gene or protein to prevent restenosis
US6363938B2 (en) * 1998-12-22 2002-04-02 Angiotrax, Inc. Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth
TWI257307B (en) * 2000-07-12 2006-07-01 Orthologic Corp Pharmaceutical composition for cardiac tissue repair

Also Published As

Publication number Publication date
US20080131474A1 (en) 2008-06-05
JP2005036007A (ja) 2005-02-10
CN100500211C (zh) 2009-06-17
JP2004502739A (ja) 2004-01-29
EP1253937A2 (en) 2002-11-06
EP1253937B1 (en) 2003-09-10
AU2001278907B2 (en) 2004-10-21
DE60100740D1 (de) 2003-10-16
US20020187933A1 (en) 2002-12-12
WO2002004008A3 (en) 2002-08-22
CA2415778A1 (en) 2002-01-17
US7034001B2 (en) 2006-04-25
US7214661B2 (en) 2007-05-08
US6867190B2 (en) 2005-03-15
US7732411B2 (en) 2010-06-08
DE60100740T4 (de) 2005-01-27
US6861407B2 (en) 2005-03-01
HK1060302A1 (zh) 2004-08-06
US20020061852A1 (en) 2002-05-23
AU7890701A (en) 2002-01-21
DE60100740T2 (de) 2004-07-01
US20050153884A1 (en) 2005-07-14
CN1455678A (zh) 2003-11-12
TWI257307B (en) 2006-07-01
ATE249238T1 (de) 2003-09-15
WO2002004008A2 (en) 2002-01-17
US20060134167A1 (en) 2006-06-22

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