JP2004501955A - リポソーム抗新生物薬剤およびその使用 - Google Patents

リポソーム抗新生物薬剤およびその使用 Download PDF

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Publication number
JP2004501955A
JP2004501955A JP2002506699A JP2002506699A JP2004501955A JP 2004501955 A JP2004501955 A JP 2004501955A JP 2002506699 A JP2002506699 A JP 2002506699A JP 2002506699 A JP2002506699 A JP 2002506699A JP 2004501955 A JP2004501955 A JP 2004501955A
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drug
liposome
active agent
liposomes
ratio
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Japanese (ja)
Inventor
マデン，　トーマス　ディー．
センプル，　シーン　シー．
アーコン，　クエト　エフ．
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アイネックス　ファーマシューティカルズ　コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002506699A 2000-06-30 2001-06-29 リポソーム抗新生物薬剤およびその使用 Withdrawn JP2004501955A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21555600P 2000-06-30 2000-06-30
US26461601P 2001-01-26 2001-01-26
PCT/CA2001/000925 WO2002002077A2 (en) 2000-06-30 2001-06-29 Liposomal antineoplastic drugs and uses thereof

Related Child Applications (1)

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JP2012025785A Division JP2012092148A (ja) 2000-06-30 2012-02-09 リポソーム抗新生物薬剤およびその使用

Publications (1)

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JP2004501955A true JP2004501955A (ja) 2004-01-22

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JP2002506699A Withdrawn JP2004501955A (ja) 2000-06-30 2001-06-29 リポソーム抗新生物薬剤およびその使用
JP2012025785A Pending JP2012092148A (ja) 2000-06-30 2012-02-09 リポソーム抗新生物薬剤およびその使用
JP2014027576A Pending JP2014088444A (ja) 2000-06-30 2014-02-17 リポソーム抗新生物薬剤およびその使用

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JP2012025785A Pending JP2012092148A (ja) 2000-06-30 2012-02-09 リポソーム抗新生物薬剤およびその使用
JP2014027576A Pending JP2014088444A (ja) 2000-06-30 2014-02-17 リポソーム抗新生物薬剤およびその使用

Country Status (12)

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US (7) US7244448B2 (enExample)
EP (2) EP1299085B1 (enExample)
JP (3) JP2004501955A (enExample)
CN (1) CN1245977C (enExample)
AT (2) ATE309787T1 (enExample)
AU (3) AU7038501A (enExample)
CA (2) CA2412790C (enExample)
DE (2) DE60115044T2 (enExample)
ES (1) ES2253398T3 (enExample)
IL (2) IL153676A0 (enExample)
MX (1) MXPA02012817A (enExample)
WO (2) WO2002002077A2 (enExample)

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JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
JP2008519045A (ja) * 2004-11-05 2008-06-05 イネックス ファーマシューティカルズ コーポレイション 薬物リポソーム製剤を安定化するための組成物および方法
JP2009520774A (ja) 2005-12-22 2009-05-28 アバンテイス・フアルマ・エス・アー コンブレタスタチンおよび抗癌剤を含む組合せ
JP2012092148A (ja) * 2000-06-30 2012-05-17 Tekmira Pharmaceuticals Corp リポソーム抗新生物薬剤およびその使用
US9801874B2 (en) 2012-11-20 2017-10-31 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine for therapeutic use
US11559486B2 (en) 2015-07-22 2023-01-24 Acrotech Biopharma, LLC Ready-to-use formulation for Vincristine Sulfate Liposome Injection

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US7452550B2 (en) * 2000-06-30 2008-11-18 Hana Biosciences, Inc. Liposomal antineoplastic drugs and uses thereof
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ATE434431T1 (de) * 2003-11-14 2009-07-15 Het Nl Kanker I The Netherland Pharmazeutische formulierungen mit kurzketten- sphingolipiden und ihre verwendung
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JP2009520774A (ja) 2005-12-22 2009-05-28 アバンテイス・フアルマ・エス・アー コンブレタスタチンおよび抗癌剤を含む組合せ
US9801874B2 (en) 2012-11-20 2017-10-31 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine for therapeutic use
US11559486B2 (en) 2015-07-22 2023-01-24 Acrotech Biopharma, LLC Ready-to-use formulation for Vincristine Sulfate Liposome Injection

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US7244448B2 (en) 2007-07-17
DE60115044T2 (de) 2006-08-03
WO2002002077A3 (en) 2002-12-12
WO2002002077A2 (en) 2002-01-10
US20020110586A1 (en) 2002-08-15
CA2412790A1 (en) 2002-01-10
EP1299084B1 (en) 2005-11-16
US20060093662A1 (en) 2006-05-04
ES2253398T3 (es) 2006-06-01
DE60115044D1 (de) 2005-12-22
CN1245977C (zh) 2006-03-22
MXPA02012817A (es) 2004-07-30
US20040170678A1 (en) 2004-09-02
ATE309786T1 (de) 2005-12-15
AU7038501A (en) 2002-01-14
IL153676A0 (en) 2003-07-06
US20130136787A1 (en) 2013-05-30
US20110086826A1 (en) 2011-04-14
ATE309787T1 (de) 2005-12-15
AU2001270385B2 (en) 2006-05-25
US7060828B2 (en) 2006-06-13
EP1299085A2 (en) 2003-04-09
EP1299085B1 (en) 2005-11-16
US20020119990A1 (en) 2002-08-29
WO2002002078A3 (en) 2002-12-27
CN1446079A (zh) 2003-10-01
CA2412795A1 (en) 2002-01-10
JP2014088444A (ja) 2014-05-15
WO2002002078A2 (en) 2002-01-10
US20060269594A1 (en) 2006-11-30
CA2412790C (en) 2012-11-06
DE60115045D1 (de) 2005-12-22
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