JP2004500308A5 - - Google Patents
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- JP2004500308A5 JP2004500308A5 JP2000535620A JP2000535620A JP2004500308A5 JP 2004500308 A5 JP2004500308 A5 JP 2004500308A5 JP 2000535620 A JP2000535620 A JP 2000535620A JP 2000535620 A JP2000535620 A JP 2000535620A JP 2004500308 A5 JP2004500308 A5 JP 2004500308A5
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- -1 5-tetrazolyl Chemical group 0.000 description 302
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Applications Claiming Priority (26)
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| HU (1) | HUP0102612A2 (de) |
| NO (1) | NO20004526L (de) |
| WO (1) | WO1999046237A1 (de) |
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| US6262044B1 (en) | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
| DE19814838C2 (de) | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| DE19946301A1 (de) | 1998-04-02 | 2001-04-19 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften |
| DE60012718T2 (de) * | 1999-04-09 | 2005-10-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Prognose von ptp lar vermittelten krankheiten |
| US6410556B1 (en) | 1999-09-10 | 2002-06-25 | Novo Nordisk A/S | Modulators of protein tyrosine phosphateses (PTPases) |
| WO2001019831A1 (en) * | 1999-09-10 | 2001-03-22 | Novo Nordisk A/S | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) |
| ATE329920T1 (de) * | 1999-09-10 | 2006-07-15 | Novo Nordisk As | Modulatoren der protein tyrosin phosphatase (ptpases) |
| US7115624B1 (en) | 1999-09-10 | 2006-10-03 | Novo Nordisk A/S | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 |
| AU7476800A (en) * | 1999-09-10 | 2001-04-10 | Novo Nordisk A/S | Method of inhibiting protein tyrosine phosphatase 1b and/or t-cell protein tyrosine phosphatase and/or other ptpases with an asp residue at position 48 |
| TWI269654B (en) * | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
| DE122008000018I1 (de) | 2000-01-21 | 2008-08-14 | Novartis Pharma Ag | Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica |
| US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| JP4993834B2 (ja) * | 2000-06-29 | 2012-08-08 | ノース ショア−ロング アイランド ジューイッシュ ヘルス システム | 細胞増殖および血管形成の調節物質、その使用方法および特定方法 |
| US6613903B2 (en) | 2000-07-07 | 2003-09-02 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPases) |
| WO2002004458A1 (en) * | 2000-07-07 | 2002-01-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| DE60118195T2 (de) * | 2000-07-07 | 2006-12-14 | Novo Nordisk A/S | Modulatoren von protein tyrosin phosphatasen (ptpasen) |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
| US6627767B2 (en) | 2000-08-29 | 2003-09-30 | Abbott Laboratories | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors |
| US6972340B2 (en) | 2000-08-29 | 2005-12-06 | Abbott Laboratories | Selective protein tyrosine phosphatatase inhibitors |
| US20020169157A1 (en) * | 2000-08-29 | 2002-11-14 | Gang Liu | Selective protein tyrosine phosphatatase inhibitors |
| US6569853B1 (en) | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| US20020152493A1 (en) * | 2000-12-06 | 2002-10-17 | Allen Keith D. | Transgenic mice containing PTP36 tyrosine phosphatase gene disruptions |
| US20020116729A1 (en) * | 2000-12-06 | 2002-08-22 | Allen Keith D. | Transgenic mice containing NTTP1 phosphatase gene disruptions |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| ATE304545T1 (de) * | 2001-06-29 | 2005-09-15 | Novo Nordisk As | Verfahren zur hemmung von tyrosinphosphatase 1b und/oder t-zellenprotein-tyrosinphosphatase und/oder anderen ptpasen mit einem asp-rest in position 48 |
| FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| AR047894A1 (es) | 2004-02-25 | 2006-03-01 | Wyeth Corp | Derivados de tiofeno como inhibidores de la proteina tirosina fosfatasa 1b (ptpasa 1b); metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por ptpasa 1b |
| CN101006076B (zh) | 2004-06-24 | 2010-09-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| EP1888548B1 (de) | 2005-05-26 | 2012-08-22 | Neuron Systems, Inc | Chinolinderivat zur Behandlung von Netzhauterkrankungen |
| CA2622608C (en) | 2005-09-14 | 2014-08-19 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| DK3219705T3 (da) | 2005-12-28 | 2020-04-14 | Vertex Pharma | Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid |
| PT2408750E (pt) | 2009-03-20 | 2015-10-15 | Vertex Pharma | Processo para a produção de modeladores do regulador de condutância transmembranar da fibrose cística |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| BR122021013836B1 (pt) | 2009-12-04 | 2022-05-24 | Sunovion Pharmaceuticals, Inc. | Composto e seu uso, composição farmacêutica |
| US9814701B2 (en) | 2009-12-11 | 2017-11-14 | Aldeyra Therapeutics, Inc. | Compositions and methods for the treatment of macular degeneration |
| CN102834393B (zh) | 2010-02-03 | 2015-07-22 | 武田药品工业株式会社 | 细胞凋亡信号调节激酶1抑制剂 |
| EP2819670A1 (de) | 2012-02-27 | 2015-01-07 | Vertex Pharmaceuticals Incorporated | Pharmazeutische zusammensetzung und verabreichung davon |
| RU2015120478A (ru) | 2012-12-20 | 2017-01-25 | Альдейра Терапьютикс, Инк. | Пери-карбинолы |
| US9687481B2 (en) | 2013-01-23 | 2017-06-27 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| AU2014209585A1 (en) | 2013-01-25 | 2015-07-23 | Aldeyra Therapeutics, Inc. | Novel traps in the treatment of macular degeneration |
| DK3030568T3 (en) | 2013-08-08 | 2019-01-07 | Galapagos Nv | THIENO [2,3-C] PYRANES AS CFTR MODULATORS |
| RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
| AU2016311158A1 (en) | 2015-08-21 | 2018-04-05 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| MX2018013472A (es) | 2016-05-09 | 2019-02-28 | Aldeyra Therapeutics Inc | Tratamiento de combinacion de trastornos y enfermedades inflamatorios oculares. |
| MX2019000980A (es) | 2016-07-29 | 2019-07-04 | Sunovion Pharmaceuticals Inc | Compuestos y composiciones y usos de los mismos. |
| JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 化合物および組成物ならびにそれらの使用 |
| JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
| EP3596040B1 (de) | 2017-03-16 | 2023-10-11 | Aldeyra Therapeutics, Inc. | Polymorphe salze von 6-chlor-3amino-2-(2-hydroxypropyl)chinolin und verwendungen davon |
| MX2020000523A (es) | 2017-08-02 | 2020-08-20 | Sunovion Pharmaceuticals Inc | Compuestos de isocromano y usos de los mismos. |
| AU2018348174A1 (en) | 2017-10-10 | 2020-04-23 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
| KR102294974B1 (ko) * | 2017-12-19 | 2021-08-27 | 와커 헤미 아게 | 옥사미도 에스테르기를 포함하는 실록산의 제조 방법 |
| CN118406063A (zh) | 2018-02-16 | 2024-07-30 | 赛诺维信制药公司 | 盐、晶型及其制备方法 |
| CN112714762A (zh) | 2018-08-06 | 2021-04-27 | 奥尔德拉医疗公司 | 多晶型化合物及其用途 |
| US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| EP3962894A4 (de) | 2019-05-02 | 2023-01-11 | Aldeyra Therapeutics, Inc. | Polymorphe verbindungen und verwendungen davon |
| MX2022012833A (es) | 2020-04-14 | 2022-11-07 | Sunovion Pharmaceuticals Inc | (s)-(4,5-dihidro-7h-tieno[2,3-c]piran-7-il)-n-metilmetanamina para tratar trastornos neurologicos y psiquiatricos. |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0831795A2 (de) * | 1995-06-07 | 1998-04-01 | Sugen, Inc. | Phosphatase inhibitoren |
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1999
- 1999-03-12 JP JP2000535620A patent/JP2004500308A/ja active Pending
- 1999-03-12 HU HU0102612A patent/HUP0102612A2/hu unknown
- 1999-03-12 EP EP99907336A patent/EP1080068A1/de not_active Withdrawn
- 1999-03-12 KR KR1020007010089A patent/KR20010041811A/ko not_active Application Discontinuation
- 1999-03-12 WO PCT/DK1999/000126 patent/WO1999046237A1/en not_active Application Discontinuation
-
2000
- 2000-09-11 NO NO20004526A patent/NO20004526L/no unknown
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