NO20004526L - Modulatorer for proteintyrosinfosfataser - Google Patents

Modulatorer for proteintyrosinfosfataser

Info

Publication number
NO20004526L
NO20004526L NO20004526A NO20004526A NO20004526L NO 20004526 L NO20004526 L NO 20004526L NO 20004526 A NO20004526 A NO 20004526A NO 20004526 A NO20004526 A NO 20004526A NO 20004526 L NO20004526 L NO 20004526L
Authority
NO
Norway
Prior art keywords
ptp
compounds
protein tyrosine
tyrosine phosphatases
diseases
Prior art date
Application number
NO20004526A
Other languages
English (en)
Other versions
NO20004526D0 (no
Inventor
Henrik Sune Andersen
Josef Vagner
Claus Bekker Jeppesen
Niels Peter Hundahl Moeller
Sven Branner
Lone Jeppesen
Ole Hvilsted Olsen
Lars Fogh Iversen
Daniel Dale Holsworth
Frank Urban Axe
Yu Ge
Todd Kevin Jones
William Charles Ripka
Roy Teruyuki Uyeda
Jing Su
Farid Bakir
Luke Milburn Judge
Original Assignee
Novo Nordisk As
Ontogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Ontogen Corp filed Critical Novo Nordisk As
Publication of NO20004526D0 publication Critical patent/NO20004526D0/no
Publication of NO20004526L publication Critical patent/NO20004526L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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Abstract

Foreliggende oppfinnelse tilveie- bringer nye forbindelser, nye prepa- rater, fremgangsmåter for deres anven- delse, og fremgangsmåter for deres fremstilling, hvor slike forbindelser er farmakologisk anvendbare inhibitorer for proteintyrosinfosfataser (PTPaser, PTP-er), slik som PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPa, PTPS, PTPu, PTP5, PTPa, PTPq, PTP(3, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR og HePTP. Disse for- bindelsene er indikert for håndteringen eller behandlingen av et bredt spekter av sykdommer, slik som autoimmunsykdom- mer, akutt og kronisk betennelse, osteoporose, forskjellige former av kreft og maligne sykdommer, og sukker- syke av type I og sukkersyke av type II.
NO20004526A 1998-03-12 2000-09-11 Modulatorer for proteintyrosinfosfataser NO20004526L (no)

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US8291298P 1998-04-24 1998-04-24
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