JP2004182726A - ２−オキソインドリン誘導体 - Google Patents
２−オキソインドリン誘導体 Download PDFInfo
- Publication number
- JP2004182726A JP2004182726A JP2003389523A JP2003389523A JP2004182726A JP 2004182726 A JP2004182726 A JP 2004182726A JP 2003389523 A JP2003389523 A JP 2003389523A JP 2003389523 A JP2003389523 A JP 2003389523A JP 2004182726 A JP2004182726 A JP 2004182726A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- ylidene
- compound
- salt
- oxoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims description 33
- -1 3- (1,5-Naphthyridine-2 (1H) -ylidene) -2-oxoindoline-6-carbaldehyde O- (pyridin-2-ylmethyl) oxime Chemical compound 0.000 claims description 14
- UAPRJYCQVCMMCM-UHFFFAOYSA-N CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CCCN1CCC(CC1)CCC(=O)O Chemical compound CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CCCN1CCC(CC1)CCC(=O)O UAPRJYCQVCMMCM-UHFFFAOYSA-N 0.000 claims description 2
- SPQSCLNSYWLMOP-UHFFFAOYSA-N N1=C(C=CC=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)C Chemical compound N1=C(C=CC=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)C SPQSCLNSYWLMOP-UHFFFAOYSA-N 0.000 claims description 2
- AIDKNQFNJKZSEH-UHFFFAOYSA-N N1=C(C=CC=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)CC Chemical compound N1=C(C=CC=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)CC AIDKNQFNJKZSEH-UHFFFAOYSA-N 0.000 claims description 2
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- ZUTVOZVAKWWUKC-UHFFFAOYSA-N S1C=NC(=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)C Chemical compound S1C=NC(=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)C ZUTVOZVAKWWUKC-UHFFFAOYSA-N 0.000 claims description 2
- JIIJXZMYPABECK-UHFFFAOYSA-N S1C=NC(=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)CC Chemical compound S1C=NC(=C1)CON=CC1=CC=C2C(C(NC2=C1)=O)=C1NC2=CC=C(C=C2C=C1)CN1CCN(CC1)CC JIIJXZMYPABECK-UHFFFAOYSA-N 0.000 claims description 2
- OBNCKNCVKJNDBV-UHFFFAOYSA-N butanoic acid ethyl ester Natural products CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 claims description 2
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| JP2003389523A JP2004182726A (ja) | 2002-11-22 | 2003-11-19 | ２−オキソインドリン誘導体 |
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| JP2002339847 | 2002-11-22 | ||
| JP2003389523A JP2004182726A (ja) | 2002-11-22 | 2003-11-19 | ２−オキソインドリン誘導体 |
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| JP2004182726A true JP2004182726A (ja) | 2004-07-02 |
| JP2004182726A5 JP2004182726A5 (enExample) | 2006-11-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501910A (ja) * | 2015-12-24 | 2019-01-24 | レスピバート・リミテツド | インドリノン化合物および線維性疾患の処置におけるそれらの使用 |
| US11208381B2 (en) | 2016-03-08 | 2021-12-28 | Respivert Limited | Indole derivatives and their use as protein kinase inhibitors |
-
2003
- 2003-11-19 JP JP2003389523A patent/JP2004182726A/ja not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501910A (ja) * | 2015-12-24 | 2019-01-24 | レスピバート・リミテツド | インドリノン化合物および線維性疾患の処置におけるそれらの使用 |
| US11046672B2 (en) | 2015-12-24 | 2021-06-29 | Respivert Limited | Indolinones compounds and their use in the treatment of fibrotic diseases |
| JP7068172B2 (ja) | 2015-12-24 | 2022-05-16 | レスピバート・リミテツド | インドリノン化合物および線維性疾患の処置におけるそれらの使用 |
| US11208381B2 (en) | 2016-03-08 | 2021-12-28 | Respivert Limited | Indole derivatives and their use as protein kinase inhibitors |
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