JP2004166690A - 抗酸化作用を有する亜鉛含有物 - Google Patents
抗酸化作用を有する亜鉛含有物 Download PDFInfo
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- JP2004166690A JP2004166690A JP2003363204A JP2003363204A JP2004166690A JP 2004166690 A JP2004166690 A JP 2004166690A JP 2003363204 A JP2003363204 A JP 2003363204A JP 2003363204 A JP2003363204 A JP 2003363204A JP 2004166690 A JP2004166690 A JP 2004166690A
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- Prior art keywords
- vitamin
- zinc
- complex
- food
- acid
- Prior art date
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- Granted
Links
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Abstract
【解決手段】本発明は、ヒスチジンを除くアミノ酸類、ビタミンCおよびUなどのビタミン類とそれらの誘導体からなる化合物を配位子として含有する亜鉛(II)有機錯体からなる抗酸化作用を有する栄養機能食品、特定保健用食品および健康補助食品などに関する。
【選択図】 なし
Description
一方、亜鉛(II)イオン(硫酸亜鉛、酢酸亜鉛、や塩化亜鉛)は無機塩であるため、生体膜の通過が難しく、生体内へ取り込まれにくい。そのような課題を克服するために、ほど良い安定性をもち、ほど良い脂溶性をもつ抗酸化作用を有する亜鉛(II)錯体としては、唯一、ビス(ヒスチジン)/亜鉛(II)錯体が知られている(非特許文献1参照)。
E. Vera C., R. Andreas R., and R.-E. Catherine A., The mechanism of action of zinc-histidine complex (Curazinc) as an antioxidant, Free Radical Res., 36, 717-8 (2002)
大気中の酸素分子は基底状態にあり反応性は低い。しかし、この酸素分子が還元されると反応性の高い活性酸素となり、組織障害性を示す。生体必須微量金属である亜鉛は、生体における様々な機能調節に必須の金属であり、生体での活性酸素消去酵素であるスーパーオキシドジスムターゼ(SOD)の活性部位に含まれており、その活性を調節する役割を担っている。したがって、亜鉛が不足すると生体内での活性酸素消去能が低下する可能性が考えられる
この発明が解決しようとしている課題は、前記、亜鉛(II)錯体を有効成分として含有する食品であり、抗酸化作用を有する組成物に関する。
本発明の食品は、前記した亜鉛(II)錯体のほかに、さらに食品上許容される単体及びそれらの混合物を含有してなる食品が好ましい。
亜鉛の鉱産塩としては、例えば、酢酸亜鉛、塩化亜鉛、硫酸亜鉛、硝酸亜鉛等が挙げられる。なお、亜鉛源として亜鉛の鉱産塩を使用した場合には、pH調整剤として、例えば、水酸化カリウム、水酸化ナトリウム、水酸化リチウム、水酸化バリウム等の塩基性水溶液や、クエン酸緩衝液、リン酸緩衝液等の緩衝液を併用してもよい。亜鉛(II)有機錯体としては、例えば、ビタミン類、ヒスチジンを除くアミノ酸類、及びそれらの誘導体からなる群より選ばれた化合物を配位子として有する亜鉛(II)有機錯体が好ましいものとして挙げられる。
本発明にかかる食品の形状は、粉末状、顆粒状、錠剤型、カプセル、液状、ゲル状、その他いずれのものでもよい。
キサンチンと酸素分子からキサンチン酸化酵素の触媒により、生成されるスーパーオキシドアニオン(O2 −)とウミホタルルシフェリン誘導体(MCLA)が反応すると化学発光を生じることを利用して、被験物質による化学発光強度の減弱をO2 −消去能として測定した。すなわち、キサンチンーキサンチン酸化酵素系で生成されたO2 −を化学発光法で測定し、対照値を100%として、SOD、ビタミン、アミノ酸などの配位子をもつ亜鉛(II)錯体、ビタミン、アミノ酸などの配位子のみ、および塩化亜鉛による化学発光強度の減弱の程度(対照に対する%)を抗酸化能として示す。
これらのことから、Zn/L-スレオニン錯体、Zn/ビタミンC錯体、およびZn/ビタミンU錯体は、活性酸素を消去する抗酸化能を有しており、それらの配位子のみと同程度の抗酸化能を有することが証明された。
以上の結果から、Zn/L-スレオニン錯体、Zn/ビタミンC錯体、およびZn/ビタミンU錯体は、亜鉛の補給と抗酸化能の両方を兼ね備えた化合物であり、生体内での抗酸化能を高める効果が期待される。
抗癌剤シスプラチンは重篤な副作用として急性腎不全を引き起こし、その発症には活性酸素が関与しているシスプラチンによる急性腎不全に対する抗酸化作用を有するZn/ビタミンC錯体の影響について調べた。実験方法は、シスプラチン(CDDP, 7.5 mg/kg, i.v.)をSD系雄性ラットに静脈内(i.v.)投与し、投与4日後に18時間採尿および採血を行った。その腎障害の程度は、血中尿素窒素(BUN)および尿中へ漏出した酵素N-acetyl-b-D-glucosaminidase(NAG)やグルコースを測定し評価した。Zn/ビタミンC錯体(100 mg/kg)は、蒸留水に溶解させ(100 mg/8mL、用時調製)ラットにCDDP投与2日前より1日1回、実験終了前日(CDDP投与3日後)まで経口投与(p.o.)した。
CDDPによる急性腎不全に対して、Zn/ビタミンC錯体は、軽減効果を示した。CDDPによる急性腎不全の発症に活性酸素が関わる事から、Zn/ビタミンC錯体による抗酸化作用で障害が軽減されたと考えられる。このことは、CDDPのみならず活性酸素が関わる腎障害に対してZn/ビタミンC錯体が、予防および治療に効果が期待出来る化合物である可能性を示唆するものである。
Claims (5)
- 亜鉛と錯体を形成し得る、ヒスチジンを除く基本アミノ酸、ビタミン及びそれらの誘導体からなる有機化合物を配位子とする亜鉛源とを含んでなる食品。
- 亜鉛源が亜鉛の鉱産塩又は有機錯体である請求項1に記載の食品。
- アミノ酸類が、スレオニン、バリン、ロイシン、イソロイシン、グリシン、プロリン、アルギニン、グルタミン、グルタミン酸、アスパラギン、アスパラギン酸、アラニン、リジン、セリン、メチオニン、フェニルアラニン、チロシン、システイン、トリプトファン、ベタイン、テアニン、及びそれらアミド類などの誘導体からなる群より選ばれた1種又は2種以上の化合物である請求項1に記載の食品。
- ビタミン類が、ビタミンB複合体であるニコチン酸やニコチンアミド、ビタミンU、アスコルビン酸(ビタミンC)、カルニチン(ビタミンBT)、葉酸、リボフラビン及びそれらの混合物からなる請求項1に記載の食品。
- 更に、他の食品類、食品添加物類、ビタミン類又は/及びミネラル類を含んでなる抗酸化剤として安全に予防できる食品。
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JP2009545590A (ja) * | 2006-08-03 | 2009-12-24 | グリゴリエヴィッチ ギトリン,イザーク | 酸化ストレスによる疾病の予防及び治療のための抗酸化剤 |
CN112739706A (zh) * | 2018-09-21 | 2021-04-30 | 朴来玉 | 包含柠檬酸及精氨酸配体的锌络合物 |
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CN103549378B (zh) * | 2013-10-28 | 2015-08-19 | 饶攀 | 一种功能蛋白酱的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5379009A (en) * | 1976-12-17 | 1978-07-13 | Ashmead H H | Method and composition for increasing essencial bivalent metal level within warm blood animal tissue |
JPH11511337A (ja) * | 1995-10-27 | 1999-10-05 | ザ プロクター アンド ギャンブル カンパニー | 鉄、亜鉛、およびビタミンで栄養強化した、色の安定な乾燥ドリンク・ミックス |
WO2000078161A2 (en) * | 1999-06-18 | 2000-12-28 | Albion International, Inc. | Cereal grain kernels fortified with amino acid chelates |
WO2002004505A1 (fr) * | 2000-06-19 | 2002-01-17 | Biowindow Gene Development Inc. Shanghai | Nouveau polypeptide, semaphorine humaine 9, et polynucleotide codant ce polypeptide |
JP2002531108A (ja) * | 1998-12-09 | 2002-09-24 | エヌ.ヴイ.ヌトゥリシア | 胸腺の成長を刺激するベビーフード |
-
2003
- 2003-10-23 JP JP2003363204A patent/JP3824604B2/ja not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5379009A (en) * | 1976-12-17 | 1978-07-13 | Ashmead H H | Method and composition for increasing essencial bivalent metal level within warm blood animal tissue |
JPH11511337A (ja) * | 1995-10-27 | 1999-10-05 | ザ プロクター アンド ギャンブル カンパニー | 鉄、亜鉛、およびビタミンで栄養強化した、色の安定な乾燥ドリンク・ミックス |
JP2002531108A (ja) * | 1998-12-09 | 2002-09-24 | エヌ.ヴイ.ヌトゥリシア | 胸腺の成長を刺激するベビーフード |
WO2000078161A2 (en) * | 1999-06-18 | 2000-12-28 | Albion International, Inc. | Cereal grain kernels fortified with amino acid chelates |
WO2002004505A1 (fr) * | 2000-06-19 | 2002-01-17 | Biowindow Gene Development Inc. Shanghai | Nouveau polypeptide, semaphorine humaine 9, et polynucleotide codant ce polypeptide |
Non-Patent Citations (2)
Title |
---|
日本栄養・食糧学会総会講演要旨集 VOL.57 P.243 (2003.04.01), JPN4006004612, ISSN: 0000720558 * |
日本栄養・食糧学会総会講演要旨集 VOL.57 P.243 (2003.04.01), JPNX006026755, ISSN: 0000747934 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009545590A (ja) * | 2006-08-03 | 2009-12-24 | グリゴリエヴィッチ ギトリン,イザーク | 酸化ストレスによる疾病の予防及び治療のための抗酸化剤 |
CN112739706A (zh) * | 2018-09-21 | 2021-04-30 | 朴来玉 | 包含柠檬酸及精氨酸配体的锌络合物 |
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