JP2004123760A5 - - Google Patents
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- Publication number
- JP2004123760A5 JP2004123760A5 JP2004005518A JP2004005518A JP2004123760A5 JP 2004123760 A5 JP2004123760 A5 JP 2004123760A5 JP 2004005518 A JP2004005518 A JP 2004005518A JP 2004005518 A JP2004005518 A JP 2004005518A JP 2004123760 A5 JP2004123760 A5 JP 2004123760A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- carbohydrate
- glutamine
- composition according
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 21
- 150000001720 carbohydrates Chemical class 0.000 claims 7
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 230000004700 cellular uptake Effects 0.000 claims 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 239000004302 potassium sorbate Substances 0.000 claims 1
- 235000010241 potassium sorbate Nutrition 0.000 claims 1
- 229940069338 potassium sorbate Drugs 0.000 claims 1
- 229940083037 simethicone Drugs 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13444299P | 1999-05-17 | 1999-05-17 | |
| US60/134,442 | 1999-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Division JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004123760A JP2004123760A (ja) | 2004-04-22 |
| JP2004123760A5 true JP2004123760A5 (enExample) | 2007-06-28 |
| JP5015411B2 JP5015411B2 (ja) | 2012-08-29 |
Family
ID=22463417
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Expired - Fee Related JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
| JP2004005518A Expired - Fee Related JP5015411B2 (ja) | 1999-05-17 | 2004-01-13 | 生体活性剤の改良された細胞取り込み |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Expired - Fee Related JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US6734170B2 (enExample) |
| EP (1) | EP1206283A2 (enExample) |
| JP (2) | JP4698843B2 (enExample) |
| AU (1) | AU779783B2 (enExample) |
| CA (1) | CA2374003C (enExample) |
| WO (1) | WO2000069470A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1206283A2 (en) * | 1999-05-17 | 2002-05-22 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
| IT1318427B1 (it) * | 2000-03-27 | 2003-08-25 | A C R Applied Coating Res S A | Gomma da masticare contenente composti aminoacidi solforati. |
| WO2004012662A2 (en) * | 2002-08-01 | 2004-02-12 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
| AU2003282619A1 (en) * | 2002-10-11 | 2004-05-04 | University Of Virginia Patent Foundation | Use of stable glutamine derivatives to improve drug absorption |
| US20040265359A1 (en) * | 2003-04-17 | 2004-12-30 | Sacks Gordon S. | Oral delivery formulations of L-glutamine |
| US7186517B2 (en) * | 2003-08-01 | 2007-03-06 | Aesgen, Inc. | Compositions and methods for monitoring breast cancer treatment |
| KR20050104152A (ko) | 2004-04-28 | 2005-11-02 | 최승호 | 경구용 약물의 흡수를 증진하는 약제학적 조성물 |
| WO2005110046A2 (en) * | 2004-05-10 | 2005-11-24 | Aesgen, Inc. | Method of enhancing uptake of keratinocyte growth factor |
| JP4804728B2 (ja) * | 2004-07-23 | 2011-11-02 | 株式会社ファンケル | Ｄｆａ含有経皮吸収促進剤 |
| KR100699279B1 (ko) | 2005-04-28 | 2007-03-23 | 학교법인 포항공과대학교 | 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법 |
| US7973084B2 (en) | 2005-04-28 | 2011-07-05 | Postech Academy-Industrial Foundation | Molecular transporters based on alditol or inositol and processes for the preparation thereof |
| US7767248B2 (en) * | 2007-02-02 | 2010-08-03 | Overly Iii Harry J | Soft chew confectionary with high fiber and sugar content and method for making same |
| US20100168074A1 (en) * | 2007-04-13 | 2010-07-01 | Christopher Culligan | Freezable Unit Dosage Delivery System and Method of Preparation |
| US20090011079A1 (en) * | 2007-07-02 | 2009-01-08 | Bestsweet, Inc. | Hard Coated Confectionary Having A Consumable Soft Chewing Core With An Active And Method For Making Same |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| CA2702604C (en) | 2008-09-22 | 2013-12-03 | Biochemics, Inc. | Transdermal drug delivery using an osmolyte and vasoactive agent |
| US8236768B2 (en) | 2008-10-03 | 2012-08-07 | 3B Pharmaceuticals, Inc. | Topical antiviral formulations |
| US12016950B2 (en) | 2010-09-01 | 2024-06-25 | Try This First, Inc. | Devices and methods for treating ear pain |
| WO2012031123A2 (en) | 2010-09-01 | 2012-03-08 | Trythisfirst, Inc. | Method of treating ear infections |
| AU2012242565B2 (en) | 2011-04-13 | 2017-05-11 | Thermolife International, Llc | N-Acetyl Beta Alanine methods of use |
| WO2013133691A1 (en) * | 2012-03-09 | 2013-09-12 | N.V. Nutricia | Liquid nutritional composition comprising free amino acids |
| US9849144B2 (en) | 2013-09-16 | 2017-12-26 | Healios Oncology Nutrition, LLC | Glutamine and trehalose compositions |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US11052094B2 (en) | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| US11154619B2 (en) | 2017-02-17 | 2021-10-26 | Creighton University | Liposomal compositions with light illumination-induced drug release |
| JP2023505841A (ja) * | 2019-12-16 | 2023-02-13 | シドネキシス，インク． | Ｄ２ｏを含む眼科用組成物 |
| WO2022104157A1 (en) | 2020-11-12 | 2022-05-19 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| IL315206A (en) | 2021-02-11 | 2024-10-01 | Thermolife Int Llc | A method of administering nitric oxide gas |
| TWI810852B (zh) | 2022-03-18 | 2023-08-01 | 生展生物科技股份有限公司 | 凝結芽孢桿菌bc198或其代謝產物用於預防或輔助治療化療導致腸道受損相關病變或菌叢失衡之用途 |
| CN119584988A (zh) * | 2022-07-19 | 2025-03-07 | 成瘾与精神健康中心 | 氨基酸口服液组合物 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3058942A (en) * | 1958-07-07 | 1962-10-16 | Standard Oil Company Of Chicag | Polyvinyl chloride homogenized with triisobutyl trimesate and method of preparation |
| US3085942A (en) * | 1960-12-28 | 1963-04-16 | Hoffmann La Roche | Antitussive compositions and preparation |
| US3957964A (en) * | 1974-01-30 | 1976-05-18 | Colgate-Palmolive Company | Dentifrice containing encapsulated flavoring |
| US4071614A (en) * | 1975-06-03 | 1978-01-31 | Colgate Palmolive Company | Dentifrice containing encapsulated flavoring |
| US4348378A (en) * | 1979-08-09 | 1982-09-07 | Kosti Carl M | Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye |
| JPS6030650B2 (ja) * | 1979-10-26 | 1985-07-17 | 日本油脂株式会社 | 座薬基剤組成物 |
| US4352825A (en) * | 1981-02-23 | 1982-10-05 | Nabisco Brands, Inc. | Coextruded chewing gum containing a soft core portion |
| US4352823A (en) * | 1981-04-13 | 1982-10-05 | Nabisco Brands, Inc. | Coextruded chewing gum containing a soft non-SBR gum core portion |
| US4439194A (en) * | 1981-09-08 | 1984-03-27 | Merck & Co., Inc. | Water and drug delivery system for suppository use |
| US4559157A (en) * | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| US4647459A (en) * | 1983-07-20 | 1987-03-03 | Warner-Lambert Company | Confectionery compositions containing magnesium trisilicate adsorbates |
| LU84979A1 (fr) * | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4885173A (en) * | 1985-05-01 | 1989-12-05 | University Of Utah | Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities |
| US4671953A (en) * | 1985-05-01 | 1987-06-09 | University Of Utah Research Foundation | Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics |
| US5763485A (en) | 1985-09-12 | 1998-06-09 | Brigham And Women's Hospital | Method of treating catabolic, gut-associated pathological processes and impaired host defenses |
| US5397803A (en) | 1985-09-12 | 1995-03-14 | Brigham And Women's Hospital | Use of glutamine to reduce rate of pathogenic microorganism infection |
| US5684045A (en) | 1985-09-12 | 1997-11-04 | Brigham And Women's Hospital | Method of treating pancreatic atrophy |
| DE3601398A1 (de) * | 1986-01-18 | 1987-07-23 | Fresenius Ag | Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen |
| US4983595A (en) * | 1986-05-22 | 1991-01-08 | Syntex (U.S.A.) Inc. | Aqueous steroid formulations for nasal administration |
| US4820508A (en) * | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) * | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US5744166A (en) * | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
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| US5438075A (en) * | 1993-03-30 | 1995-08-01 | Skubitz; Keith M. | Oral glutamine to reduce stomatitis |
| US5438042B1 (en) * | 1993-10-08 | 1997-08-26 | Sandoz Nutrition Ltd | Enteral nutritional composition having amino acid profile |
| US5726146A (en) * | 1994-12-06 | 1998-03-10 | Natural Supplement Association, Incorporated | Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass |
| US5569466A (en) * | 1995-05-17 | 1996-10-29 | R. P. Scherer Corporation | Fill compositions for soft elastic gel capsules |
| JPH11292787A (ja) * | 1995-08-15 | 1999-10-26 | Asahi Chem Ind Co Ltd | 生理活性ペプチドを含有する経粘膜投与製剤 |
| WO1997014310A1 (en) * | 1995-10-13 | 1997-04-24 | Novo Nordisk A/S | Fungicidal carbohydrate preparations |
| GB9523833D0 (en) * | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
| KR100611516B1 (ko) * | 1996-01-12 | 2007-04-25 | 테이코쿠메딕스 가부시키가이샤 | 젤리상경구의약조성물 |
| US5716959A (en) * | 1996-02-13 | 1998-02-10 | T. Ronald Theodore | Method of treating disease with piperazine zwitterion compounds |
| US5891467A (en) * | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| US5849335A (en) * | 1997-06-02 | 1998-12-15 | Nestec S.A. | Composition and method for providing glutamine |
| JPH11302200A (ja) * | 1998-04-15 | 1999-11-02 | Sumitomo Pharmaceut Co Ltd | 崩壊性の改善されたｌ−グルタミン及びメタケイ酸アルミン酸マグネシウム含有製剤 |
| JP4231940B2 (ja) * | 1998-04-15 | 2009-03-04 | 大日本除蟲菊株式会社 | ゲファルナート及びｌ−グルタミン含有製剤 |
| JP4423682B2 (ja) * | 1998-04-20 | 2010-03-03 | 味の素株式会社 | 輸液用グルタミン凍結乾燥物の調製法 |
| US6159492A (en) * | 1999-03-04 | 2000-12-12 | Manzone; Cheryl | Drug storage and delivery system containing a medicated lollipop |
| EP1206283A2 (en) * | 1999-05-17 | 2002-05-22 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
| US6391332B1 (en) * | 2000-04-20 | 2002-05-21 | Baxter International, Inc. | Therapeutic micronutrient composition for severe trauma, burns and critical illness |
| US6479068B1 (en) * | 2000-06-30 | 2002-11-12 | Baxter International Inc. | Therapeutic nutrient regimen for alleviating mucositis, stomatitis and cachexia in oncology patients |
| ATE410459T1 (de) * | 2002-01-14 | 2008-10-15 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
| WO2004012662A2 (en) * | 2002-08-01 | 2004-02-12 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
| US20040265359A1 (en) * | 2003-04-17 | 2004-12-30 | Sacks Gordon S. | Oral delivery formulations of L-glutamine |
-
2000
- 2000-05-15 EP EP00930732A patent/EP1206283A2/en not_active Withdrawn
- 2000-05-15 CA CA002374003A patent/CA2374003C/en not_active Expired - Fee Related
- 2000-05-15 WO PCT/US2000/013260 patent/WO2000069470A2/en not_active Ceased
- 2000-05-15 AU AU48501/00A patent/AU779783B2/en not_active Ceased
- 2000-05-15 JP JP2000617930A patent/JP4698843B2/ja not_active Expired - Fee Related
-
2001
- 2001-11-14 US US09/993,465 patent/US6734170B2/en not_active Expired - Lifetime
-
2004
- 2004-01-13 JP JP2004005518A patent/JP5015411B2/ja not_active Expired - Fee Related
- 2004-03-09 US US10/796,261 patent/US7041651B2/en not_active Expired - Lifetime
-
2005
- 2005-10-21 US US11/255,771 patent/US20060121091A1/en not_active Abandoned
-
2007
- 2007-02-27 US US11/679,517 patent/US20080021106A1/en not_active Abandoned
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