JP2004089204A5 - - Google Patents

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Publication number
JP2004089204A5
JP2004089204A5 JP2003398813A JP2003398813A JP2004089204A5 JP 2004089204 A5 JP2004089204 A5 JP 2004089204A5 JP 2003398813 A JP2003398813 A JP 2003398813A JP 2003398813 A JP2003398813 A JP 2003398813A JP 2004089204 A5 JP2004089204 A5 JP 2004089204A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003398813A
Other languages
Japanese (ja)
Other versions
JP2004089204A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2004089204A publication Critical patent/JP2004089204A/ja
Publication of JP2004089204A5 publication Critical patent/JP2004089204A5/ja
Pending legal-status Critical Current

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JP2003398813A 1990-05-03 2003-11-28 遺伝病を検出するための熱安定リガーゼによるdna増幅系 Pending JP2004089204A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51844790A 1990-05-03 1990-05-03

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP50889191A Division JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Publications (2)

Publication Number Publication Date
JP2004089204A JP2004089204A (ja) 2004-03-25
JP2004089204A5 true JP2004089204A5 (enExample) 2005-05-26

Family

ID=24063976

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50889191A Expired - Lifetime JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2001060432A Pending JP2001269187A (ja) 1990-05-03 2001-03-05 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2003398813A Pending JP2004089204A (ja) 1990-05-03 2003-11-28 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP50889191A Expired - Lifetime JP3889807B2 (ja) 1990-05-03 1991-04-29 遺伝病を検出するための熱安定リガーゼによるdna増幅系
JP2001060432A Pending JP2001269187A (ja) 1990-05-03 2001-03-05 遺伝病を検出するための熱安定リガーゼによるdna増幅系

Country Status (7)

Country Link
EP (2) EP1507000B1 (enExample)
JP (3) JP3889807B2 (enExample)
AT (2) ATE375392T1 (enExample)
DE (2) DE69133629D1 (enExample)
DK (1) DK0528882T3 (enExample)
ES (1) ES2294777T3 (enExample)
WO (1) WO1991017239A1 (enExample)

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DE4217134A1 (de) * 1992-05-23 1993-11-25 Boehringer Mannheim Gmbh Thermostabile Ligase aus Archaebakterien
US5700672A (en) * 1992-07-23 1997-12-23 Stratagene Purified thermostable pyrococcus furiousus DNA ligase
DE69329824T2 (de) * 1992-08-03 2001-08-09 Abbott Laboratories, Abbott Park Nachweis und amplifikation bestimmter nukleinsäuren mittels exonukleolytischer aktivität
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
US5462854A (en) * 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
WO1995027078A1 (en) * 1994-04-04 1995-10-12 Ciba Corning Diagnostics Corp. Hibridization-ligation assays for the detection of specific nucleic acid sequences
WO1996012824A2 (en) * 1994-10-21 1996-05-02 Abbott Laboratories Use of spermidine to relieve inhibition of ligase chain reaction in a clinical test sample
WO1996014403A1 (en) * 1994-11-04 1996-05-17 Genis Hf. A gene from the bacterium rhodothermus marinus, coding for the amino acid sequence of dna-ligase, produced in escherichia coli or some other suitable host organism
CA2244891C (en) 1996-02-09 2008-12-30 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
JP4468488B2 (ja) 1996-05-29 2010-05-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
AU776810B2 (en) * 1996-07-19 2004-09-23 Cornell Research Foundation Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
AU776820B2 (en) * 1998-10-30 2004-09-23 Cornell Research Foundation Inc. High fidelity thermostable ligase and uses thereof
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
DE50001774D1 (de) 1999-09-29 2003-05-22 Tecan Trading Ag Maennedorf Thermocycler sowie Hebeelement für Mikrotiterplatte
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
CA2405412A1 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US6942836B2 (en) 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US7309575B2 (en) * 2002-01-16 2007-12-18 The University Of North Carolina At Chapel Hill Protein purification and detection methods
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
US7364855B2 (en) 2004-04-30 2008-04-29 Applera Corporation Methods and kits for methylation detection
US7427479B2 (en) 2004-04-30 2008-09-23 Applera Corporation Methods and kits for identifying target nucleotides in mixed populations
US7709201B2 (en) 2004-08-24 2010-05-04 Cornell Research Foundation, Inc. Detection of nucleic acid differences using endonuclease cleavage/ligase resealing reactions and capillary electrophoresis or microarrays
US7807370B2 (en) 2005-08-16 2010-10-05 Merlogen, Llc Methods for identification of merle gene
US7285388B1 (en) 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
WO2009087687A1 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection process and uses thereof
WO2009087686A2 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection methods
CA3187713A1 (en) 2014-10-08 2016-04-14 Cornell University Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention
WO2025197400A1 (ja) * 2024-03-19 2025-09-25 デンカ株式会社 高い正確性で、ミスマッチ塩基対を有さない配列を接合するリガーゼ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
WO1989009835A1 (en) * 1988-04-08 1989-10-19 The Salk Institute For Biological Studies Ligase-based amplification method
US4879214A (en) * 1988-11-15 1989-11-07 E. I. Du Pont De Nemours And Company Differentiation of nucleic acid segments on the basis of nucleotide differences
AU627809B2 (en) * 1988-12-16 1992-09-03 Abbott Laboratories Isolating thermostable enzymes from engineered mesophiles

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