JP2003535965A5 - - Google Patents
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- JP2003535965A5 JP2003535965A5 JP2002503303A JP2002503303A JP2003535965A5 JP 2003535965 A5 JP2003535965 A5 JP 2003535965A5 JP 2002503303 A JP2002503303 A JP 2002503303A JP 2002503303 A JP2002503303 A JP 2002503303A JP 2003535965 A5 JP2003535965 A5 JP 2003535965A5
- Authority
- JP
- Japan
- Prior art keywords
- neunac
- linked
- bond
- residue
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 25
- 239000000126 substance Substances 0.000 description 23
- PNIWLNAGKUGXDO-LNCRCTFVSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical group O[C@@H]1[C@@H](N)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 PNIWLNAGKUGXDO-LNCRCTFVSA-N 0.000 description 17
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 16
- 150000002482 oligosaccharides Polymers 0.000 description 12
- 241000712461 unidentified influenza virus Species 0.000 description 11
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 206010022000 influenza Diseases 0.000 description 8
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 3
- 229930186217 Glycolipid Natural products 0.000 description 3
- 229940123424 Neuraminidase inhibitor Drugs 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 239000002911 sialidase inhibitor Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20001477A FI20001477A7 (fi) | 2000-06-21 | 2000-06-21 | Influenssavirusta sitova aine ja sen käyttö |
| FI20001477 | 2000-06-21 | ||
| PCT/FI2001/000587 WO2001097819A1 (en) | 2000-06-21 | 2001-06-20 | Influenza virus binding, sialylated oligosaccharide substance and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535965A JP2003535965A (ja) | 2003-12-02 |
| JP2003535965A5 true JP2003535965A5 (enExample) | 2008-07-31 |
Family
ID=8558611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002503303A Pending JP2003535965A (ja) | 2000-06-21 | 2001-06-20 | インフルエンザウイルス結合性シアル化オリゴ糖含有物質およびその用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7902170B2 (enExample) |
| EP (1) | EP1320374A1 (enExample) |
| JP (1) | JP2003535965A (enExample) |
| AU (1) | AU7257101A (enExample) |
| FI (1) | FI20001477A7 (enExample) |
| WO (1) | WO2001097819A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20031536A0 (fi) * | 2003-10-20 | 2003-10-20 | Biotie Therapies Oyj | Korkean affiniteetin ligandit influenssavirukselle ja menetelmät niiden valmistamiseen |
| WO2006025443A1 (ja) | 2004-08-31 | 2006-03-09 | National Institute Of Advanced Industrial Scienceand Technology | ラクトシルセラミドを生産する遺伝子組換え植物、およびその利用 |
| JP2006288210A (ja) | 2005-04-05 | 2006-10-26 | National Institute Of Advanced Industrial & Technology | 糖転移酵素遺伝子の導入による生体内糖鎖伸長の技術 |
| FI20060200A0 (fi) * | 2005-04-20 | 2006-02-27 | Glykos Finland Oy | Menetelmä ihmisen influenssaviruksen sialihahappositoumisspesifisyyden analysoimiseksi |
| WO2007026669A1 (ja) * | 2005-09-02 | 2007-03-08 | Shizuoka Prefectural Universities Corporation | ウイルスレセプター糖鎖認識特異性の判別方法 |
| EP2060257A1 (en) * | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
| US20250302865A1 (en) * | 2022-03-16 | 2025-10-02 | Pharmalectin, Inc. | Lectin-binding carbohydrates for treating viral infections |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0508493A1 (en) * | 1986-08-06 | 1992-10-14 | Mect Corporation | Ganglioside related compounds and method of producing the same |
| US5254676A (en) * | 1991-11-22 | 1993-10-19 | E. I. Du Pont De Nemours And Company | Oligosaccharide inhibitors for influenza virus |
| US5220008A (en) * | 1991-11-22 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Oligosaccharide inhibitors for influenza virus |
| US5736533A (en) * | 1995-06-07 | 1998-04-07 | Neose Technologies, Inc. | Bacterial inhibition with an oligosaccharide compound |
| CA2261877C (en) * | 1996-07-23 | 2009-04-07 | Seikagaku Corporation | Novel lactosamine oligosaccharide and method for producing the same |
-
2000
- 2000-06-21 FI FI20001477A patent/FI20001477A7/fi unknown
-
2001
- 2001-06-20 JP JP2002503303A patent/JP2003535965A/ja active Pending
- 2001-06-20 EP EP01951715A patent/EP1320374A1/en not_active Withdrawn
- 2001-06-20 AU AU72571/01A patent/AU7257101A/en not_active Abandoned
- 2001-06-20 US US10/311,713 patent/US7902170B2/en not_active Expired - Fee Related
- 2001-06-20 WO PCT/FI2001/000587 patent/WO2001097819A1/en not_active Ceased
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