JP2003535868A5 - - Google Patents
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- Publication number
- JP2003535868A5 JP2003535868A5 JP2002501905A JP2002501905A JP2003535868A5 JP 2003535868 A5 JP2003535868 A5 JP 2003535868A5 JP 2002501905 A JP2002501905 A JP 2002501905A JP 2002501905 A JP2002501905 A JP 2002501905A JP 2003535868 A5 JP2003535868 A5 JP 2003535868A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 9
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 125000000304 alkynyl group Chemical group 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 239000001257 hydrogen Chemical group 0.000 description 2
- FMUSQJSIDCDCPB-UHFFFAOYSA-N 4-acetamidoicosan-5-yl acetate Chemical compound CCCCCCCCCCCCCCCC(OC(C)=O)C(CCC)NC(C)=O FMUSQJSIDCDCPB-UHFFFAOYSA-N 0.000 description 1
- SYFQZCUQZJXUQE-UHFFFAOYSA-N 4-aminoicosan-5-ol Chemical compound CCCCCCCCCCCCCCCC(O)C(N)CCC SYFQZCUQZJXUQE-UHFFFAOYSA-N 0.000 description 1
- UITJBVDUQMDHTE-UHFFFAOYSA-N 4-aminoicosan-5-ol;hydrochloride Chemical compound Cl.CCCCCCCCCCCCCCCC(O)C(N)CCC UITJBVDUQMDHTE-UHFFFAOYSA-N 0.000 description 1
- RCYFWNYHEBGXJX-UHFFFAOYSA-N 4-aminoicosan-5-one;hydrobromide Chemical compound Br.CCCCCCCCCCCCCCCC(=O)C(N)CCC RCYFWNYHEBGXJX-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0013783A GB0013783D0 (en) | 2000-06-06 | 2000-06-06 | New antitumoral derivatives of spisulosine-285 |
| GB0013783.6 | 2000-06-06 | ||
| GB0102472.8 | 2001-01-31 | ||
| GB0102472A GB0102472D0 (en) | 2001-01-31 | 2001-01-31 | New antitumoral derivatives of spisulosine-285 |
| GB0104732.3 | 2001-02-26 | ||
| GB0104732A GB0104732D0 (en) | 2001-02-26 | 2001-02-26 | New antitumoral derivatives of spisulosine-285 |
| PCT/GB2001/002487 WO2001094357A1 (en) | 2000-06-06 | 2001-06-06 | Antitumoral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535868A JP2003535868A (ja) | 2003-12-02 |
| JP2003535868A5 true JP2003535868A5 (enExample) | 2008-07-24 |
Family
ID=27255753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501905A Pending JP2003535868A (ja) | 2000-06-06 | 2001-06-06 | 抗腫瘍化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7138547B2 (enExample) |
| EP (1) | EP1287006B1 (enExample) |
| JP (1) | JP2003535868A (enExample) |
| AT (1) | ATE376552T1 (enExample) |
| AU (2) | AU6251801A (enExample) |
| BR (1) | BR0111505A (enExample) |
| CA (1) | CA2410409A1 (enExample) |
| DE (1) | DE60131076T2 (enExample) |
| ES (1) | ES2293996T3 (enExample) |
| IL (2) | IL153096A0 (enExample) |
| MX (1) | MXPA02012121A (enExample) |
| WO (1) | WO2001094357A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003005965A2 (en) * | 2001-07-11 | 2003-01-23 | Musc Foundation For Research Development | Modulators of ceramidase and methods of use based thereon |
| FR2847473B1 (fr) * | 2002-11-25 | 2007-06-29 | Expanscience Lab | Composition comprenant au moins une oxazolidinone, son utilisation cosmetique et comme medicament |
| US7960589B2 (en) * | 2006-09-06 | 2011-06-14 | Emory University | Synthesis of sphingosines and their derivatives |
| US8431733B2 (en) * | 2008-03-12 | 2013-04-30 | Virobay, Inc. | Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives |
| WO2014118556A2 (en) * | 2013-01-31 | 2014-08-07 | Research Foundation Of The City University Of New York | Selective inhibitors and allosteric activators of sphingosine kinase |
| JP6661192B2 (ja) * | 2016-01-19 | 2020-03-11 | 国立大学法人北海道大学 | Ｓｍｓ２阻害活性を有するセラミド誘導体 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB546383A (en) * | 1940-10-08 | 1942-07-10 | Frank Lodge | New wool dyestuffs |
| US2399118A (en) | 1942-02-13 | 1946-04-23 | Mallinckrodt Chemical Works | 2-oxazolidone compounds and method for preparing the same |
| US2363082A (en) * | 1943-01-20 | 1944-11-21 | Novocol Chemical Mfg Co Inc | Anesthetic compounds, intermediates, and processes therefor |
| US2424311A (en) * | 1943-11-10 | 1947-07-22 | Merck & Co Inc | Process for making esters of 7,8-diamino nonoic acid |
| DE828547C (de) * | 1949-08-21 | 1952-01-17 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von Komplexsalzbildnern |
| GB1057651A (en) * | 1963-01-16 | 1967-02-08 | Merck & Co Inc | Chlorinated amino acids and their preparation |
| GB1433920A (en) | 1973-10-01 | 1976-04-28 | Ici Ltd | Alkanolamine derivatives |
| US6800661B1 (en) * | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| US6107520A (en) * | 1997-04-15 | 2000-08-22 | The Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| US6756504B2 (en) * | 2000-04-19 | 2004-06-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sphingolipids |
| EP1363643A2 (en) * | 2000-12-22 | 2003-11-26 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor |
| JP3692492B2 (ja) * | 2001-05-01 | 2005-09-07 | 独立行政法人科学技術振興機構 | 新規なスフィンゴ脂質合成阻害剤 |
| WO2003045928A1 (en) * | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| BR0205172A (pt) * | 2001-12-20 | 2004-06-29 | Cosmoferm Bv | Processo para a sìntese de esfingosina |
-
2001
- 2001-06-06 CA CA002410409A patent/CA2410409A1/en not_active Abandoned
- 2001-06-06 EP EP01936649A patent/EP1287006B1/en not_active Expired - Lifetime
- 2001-06-06 AT AT01936649T patent/ATE376552T1/de not_active IP Right Cessation
- 2001-06-06 ES ES01936649T patent/ES2293996T3/es not_active Expired - Lifetime
- 2001-06-06 BR BR0111505-7A patent/BR0111505A/pt not_active IP Right Cessation
- 2001-06-06 AU AU6251801A patent/AU6251801A/xx active Pending
- 2001-06-06 MX MXPA02012121A patent/MXPA02012121A/es active IP Right Grant
- 2001-06-06 DE DE60131076T patent/DE60131076T2/de not_active Expired - Lifetime
- 2001-06-06 IL IL15309601A patent/IL153096A0/xx unknown
- 2001-06-06 JP JP2002501905A patent/JP2003535868A/ja active Pending
- 2001-06-06 US US10/297,352 patent/US7138547B2/en not_active Expired - Fee Related
- 2001-06-06 AU AU2001262518A patent/AU2001262518B2/en not_active Ceased
- 2001-06-06 WO PCT/GB2001/002487 patent/WO2001094357A1/en not_active Ceased
-
2002
- 2002-11-26 IL IL153096A patent/IL153096A/en unknown
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