JP2003532735A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003532735A5 JP2003532735A5 JP2001582349A JP2001582349A JP2003532735A5 JP 2003532735 A5 JP2003532735 A5 JP 2003532735A5 JP 2001582349 A JP2001582349 A JP 2001582349A JP 2001582349 A JP2001582349 A JP 2001582349A JP 2003532735 A5 JP2003532735 A5 JP 2003532735A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound according
- halogen
- furanosyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 26
- 125000000217 alkyl group Chemical group 0.000 description 19
- 229910052736 halogen Inorganic materials 0.000 description 14
- 150000002367 halogens Chemical class 0.000 description 14
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 208000036142 Viral infection Diseases 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000009385 viral infection Effects 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 150000001345 alkine derivatives Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 150000001356 alkyl thiols Chemical class 0.000 description 1
- 150000001504 aryl thiols Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical group [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0011203.7 | 2000-05-09 | ||
| GBGB0011203.7A GB0011203D0 (en) | 2000-05-09 | 2000-05-09 | Chemical compounds |
| PCT/GB2001/002004 WO2001085749A1 (en) | 2000-05-09 | 2001-05-08 | Anti-viral pyrimidine nucleoside analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003532735A JP2003532735A (ja) | 2003-11-05 |
| JP2003532735A5 true JP2003532735A5 (enExample) | 2008-04-03 |
Family
ID=9891276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001582349A Pending JP2003532735A (ja) | 2000-05-09 | 2001-05-08 | 抗ウイルスピリミジンヌクレオシド類 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7019135B2 (enExample) |
| EP (1) | EP1280813B1 (enExample) |
| JP (1) | JP2003532735A (enExample) |
| AT (1) | ATE254132T1 (enExample) |
| AU (1) | AU780879B2 (enExample) |
| CA (1) | CA2406633A1 (enExample) |
| DE (1) | DE60101223T2 (enExample) |
| DK (1) | DK1280813T3 (enExample) |
| ES (1) | ES2210153T3 (enExample) |
| GB (1) | GB0011203D0 (enExample) |
| NZ (1) | NZ521877A (enExample) |
| PT (1) | PT1280813E (enExample) |
| TR (1) | TR200302313T4 (enExample) |
| WO (1) | WO2001085749A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| EP1167972B1 (en) | 1998-01-23 | 2017-03-08 | Kiadis Pharma Intellectual Property B.V. | Enzyme catalyzed therapeutic agents |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| CA2378187C (en) | 1999-07-22 | 2011-09-13 | Newbiotics, Inc. | Methods for treating therapy-resistant tumors |
| GB0009486D0 (en) * | 2000-04-17 | 2000-06-07 | Univ Cardiff | Chemical compounds |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| GB0609178D0 (en) | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| CN103842369A (zh) | 2011-03-31 | 2014-06-04 | 埃迪尼克斯医药公司 | 用于治疗病毒感染的化合物和药物组合物 |
| GB201111779D0 (en) * | 2011-07-08 | 2011-08-24 | Univ Cardiff | Chemical compounds |
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的３’，５’－環磷酸酯及用於治療病毒感染之醫藥組成物 |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| EP2852604B1 (en) | 2012-05-22 | 2017-04-12 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| HK1203514A1 (en) | 2012-05-22 | 2015-10-30 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| PT2861611T (pt) | 2012-05-25 | 2016-10-11 | Janssen Sciences Ireland Uc | Nucleósidos de espirooxetano de uracilo |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| CN104936970A (zh) | 2012-10-08 | 2015-09-23 | 埃迪尼克斯医药公司 | 用于hcv感染的2′-氯核苷类似物 |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| EP2970358B1 (en) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy nucleosides for the treatment of hcv |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62255499A (ja) * | 1986-04-28 | 1987-11-07 | Teijin Ltd | 螢光性ヌクレオシド又はヌクレオチド |
| GB9708611D0 (en) * | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
| GB9716231D0 (en) * | 1997-07-31 | 1997-10-08 | Amersham Int Ltd | Base analogues |
-
2000
- 2000-05-09 GB GBGB0011203.7A patent/GB0011203D0/en not_active Ceased
-
2001
- 2001-05-08 PT PT01928079T patent/PT1280813E/pt unknown
- 2001-05-08 AT AT01928079T patent/ATE254132T1/de not_active IP Right Cessation
- 2001-05-08 DE DE60101223T patent/DE60101223T2/de not_active Expired - Fee Related
- 2001-05-08 CA CA002406633A patent/CA2406633A1/en not_active Abandoned
- 2001-05-08 AU AU54945/01A patent/AU780879B2/en not_active Ceased
- 2001-05-08 JP JP2001582349A patent/JP2003532735A/ja active Pending
- 2001-05-08 ES ES01928079T patent/ES2210153T3/es not_active Expired - Lifetime
- 2001-05-08 TR TR2003/02313T patent/TR200302313T4/xx unknown
- 2001-05-08 EP EP01928079A patent/EP1280813B1/en not_active Expired - Lifetime
- 2001-05-08 WO PCT/GB2001/002004 patent/WO2001085749A1/en not_active Ceased
- 2001-05-08 NZ NZ521877A patent/NZ521877A/en unknown
- 2001-05-08 DK DK01928079T patent/DK1280813T3/da active
- 2001-05-08 US US10/275,635 patent/US7019135B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003532735A5 (enExample) | ||
| JP4959900B2 (ja) | 抗ウイルスピリミジンヌクレオシド類 | |
| JP2004506606A5 (enExample) | ||
| JPH11193282A5 (enExample) | ||
| JP2005511531A5 (enExample) | ||
| JP2005510476A5 (enExample) | ||
| JP2001525411A5 (enExample) | ||
| CA2545427A1 (en) | Selective kinase inhibitors | |
| TR200102490T2 (tr) | Fenil ve piridinil türevleri | |
| MXPA04003532A (es) | Pirimidinonas como receptor 1 de la hormona concentradora de melanina. | |
| AP1753A (en) | Thiophene derivatives as antiviral agents for flavvivirus infection | |
| WO2005084192A3 (en) | Novel 2’-c-methyl nucleoside derivatives | |
| JP2008526999A5 (enExample) | ||
| JP2003532735A (ja) | 抗ウイルスピリミジンヌクレオシド類 | |
| CA2468649A1 (en) | Adenosine a2a receptor antagonists | |
| JP2002520282A5 (enExample) | ||
| JP2006515339A5 (enExample) | ||
| EP1125936A3 (en) | Aryl substituted azabenzimidazoles and their use in the treatment of HIV and AIDS related diseases | |
| JP2002525323A5 (enExample) | ||
| JP2004503564A5 (enExample) | ||
| LU91178I2 (fr) | Emtricitabine / Tenofovir Disoproxil et ses dérivés pharmaceutiquement acceptables (TRUVADA). | |
| NO20052074L (no) | Substituerte benzoksazinoner og anvendelser derav. | |
| JP2002506864A5 (enExample) | ||
| CY1105752T1 (el) | Παραγωγα ιμιδαζοπυριδινης μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα πepιεχουν | |
| WO2003059878A3 (en) | Thieno (3, 2-b) pyridones as antiviral compounds |