JP2003532409A5 - - Google Patents

Download PDF

Info

Publication number
JP2003532409A5
JP2003532409A5 JP2001582397A JP2001582397A JP2003532409A5 JP 2003532409 A5 JP2003532409 A5 JP 2003532409A5 JP 2001582397 A JP2001582397 A JP 2001582397A JP 2001582397 A JP2001582397 A JP 2001582397A JP 2003532409 A5 JP2003532409 A5 JP 2003532409A5
Authority
JP
Japan
Prior art keywords
variable region
antigen
human
dendritic cells
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001582397A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003532409A (ja
JP5007409B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/015114 external-priority patent/WO2001085798A2/en
Publication of JP2003532409A publication Critical patent/JP2003532409A/ja
Publication of JP2003532409A5 publication Critical patent/JP2003532409A5/ja
Application granted granted Critical
Publication of JP5007409B2 publication Critical patent/JP5007409B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2001582397A 2000-05-08 2001-05-08 樹状細胞に対するヒトモノクローナル抗体 Expired - Fee Related JP5007409B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20312600P 2000-05-08 2000-05-08
US60/203,126 2000-05-08
US23073900P 2000-09-07 2000-09-07
US60/230,739 2000-09-07
PCT/US2001/015114 WO2001085798A2 (en) 2000-05-08 2001-05-08 Human monoclonal antibodies to dendritic cells

Publications (3)

Publication Number Publication Date
JP2003532409A JP2003532409A (ja) 2003-11-05
JP2003532409A5 true JP2003532409A5 (https=) 2008-06-19
JP5007409B2 JP5007409B2 (ja) 2012-08-22

Family

ID=26898333

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001582397A Expired - Fee Related JP5007409B2 (ja) 2000-05-08 2001-05-08 樹状細胞に対するヒトモノクローナル抗体

Country Status (13)

Country Link
US (1) US7563876B2 (https=)
EP (1) EP1282646B1 (https=)
JP (1) JP5007409B2 (https=)
KR (2) KR100643818B1 (https=)
CN (1) CN1452636B (https=)
AT (1) ATE553131T1 (https=)
AU (2) AU2001261383B2 (https=)
CA (1) CA2408594A1 (https=)
DK (1) DK1282646T3 (https=)
IL (2) IL152652A0 (https=)
MX (1) MXPA02010869A (https=)
NZ (1) NZ534864A (https=)
WO (1) WO2001085798A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE553131T1 (de) 2000-05-08 2012-04-15 Celldex Res Corp Humane monoklonale antikörper gegen dendritische zellen
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
US20060222633A1 (en) * 2000-05-11 2006-10-05 Yale University Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CN1312181C (zh) 2001-02-12 2007-04-25 米德列斯公司 抗Fcα受体(CD89)的人单克隆抗体
US20050215472A1 (en) 2001-10-23 2005-09-29 Psma Development Company, Llc PSMA formulations and uses thereof
WO2003034903A2 (en) 2001-10-23 2003-05-01 Psma Development Company, L.L.C. Psma antibodies and protein multimers
US9238081B2 (en) 2002-06-14 2016-01-19 Immunomedics, Inc. Detection of early-stage pancreatic adenocarcinoma
CA2514979A1 (en) * 2003-01-31 2004-09-02 Celldex Therapeutics, Inc. Antibody vaccine conjugates and uses therefor
US9259459B2 (en) * 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
JP2007537753A (ja) * 2004-05-17 2007-12-27 ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 抗原でパルスされた、二重特異性抗体（ＢｉＡｂ）でコーティングされた樹状細胞の使用
WO2006073921A2 (en) * 2004-12-30 2006-07-13 The Rockefeller University Compositions and methods for enhanced dendritic cell maturation and function
HRP20140338T1 (hr) 2005-07-25 2014-06-20 Emergent Product Development Seattle, Llc Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20
WO2007146968A2 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
JP2008029319A (ja) * 2006-06-28 2008-02-14 Yoichiro Iwakura 樹状細胞免疫受容体遺伝子ノックアウト疾患モデル動物
NZ599777A (en) 2007-11-07 2013-09-27 Celldex Therapeutics Inc Antibodies that bind human dendritic and epithelial cell 205 (DEC-205)
EP2365003A1 (en) 2008-04-11 2011-09-14 Emergent Product Development Seattle, LLC CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
WO2010022225A1 (en) * 2008-08-20 2010-02-25 Ibc Pharmaceuticals, Inc. Dock-and-lock (dnl) vaccines for cancer therapy
EP2326350B1 (en) 2008-09-08 2013-09-04 Psma Development Company, L.L.C. Compounds for killing psma-expressing, taxane-resistant cancer cells
DK2406286T3 (en) 2009-03-10 2016-08-22 Baylor Res Inst Anti-cd40 antibodies and uses thereof
EP2406289B1 (en) 2009-03-10 2017-02-22 Baylor Research Institute Antigen presenting cell targeted anti-viral vaccines
JP2013504599A (ja) * 2009-09-14 2013-02-07 ベイラー リサーチ インスティテュート ランゲルハンス細胞に向けられたワクチン
CN113461819B (zh) 2011-04-29 2024-01-02 埃派斯进有限公司 抗-cd40抗体及其使用方法
MX2014004521A (es) * 2011-10-20 2014-05-28 Esbatech A Novartis Co Llc Anticuerpo estable de union a antigenos multiples.
WO2014066271A1 (en) * 2012-10-22 2014-05-01 Becton, Dickinson And Company Non-b-lineage cells capable of producing antibody
AU2013337903B2 (en) 2012-10-30 2018-08-16 Apexigen, Inc. Anti-CD40 antibodies and methods of use
JP7037884B2 (ja) 2014-01-13 2022-03-17 ベイラー リサーチ インスティテュート Ｈｐｖ及びｈｐｖ関連疾患に対する新規のワクチン
EP3352760B1 (en) 2015-09-21 2026-03-11 Aptevo Research and Development LLC Cd3 binding polypeptides
US10610585B2 (en) 2017-09-26 2020-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating and preventing HIV
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
KR20210089659A (ko) * 2018-10-05 2021-07-16 제노세라퓨틱스, 인코포레이티드 이종이식 생성물 및 방법
CN113429481B (zh) * 2021-07-07 2022-05-31 江苏农牧科技职业学院 一种靶向树突状细胞的纳米抗体分子及应用
WO2023070317A1 (zh) * 2021-10-26 2023-05-04 江苏省农业科学院 基于dc细胞的双功能纳米抗体及其构建方法和应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865689A (en) * 1972-11-09 1975-02-11 Hoffmann La Roche Method of producing carcinoembryonic antigens
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5053224A (en) * 1983-11-07 1991-10-01 Hilary Koprowski Induction of antibody response to solid tumors with anti-idiotype antibodies
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
AU613590B2 (en) * 1986-11-19 1991-08-08 Bristol-Myers Squibb Company Hybridomas producing monoclonal antibodies to new mucin epitopes
US5683674A (en) * 1987-01-07 1997-11-04 Imperial Cancer Research Technology Ltd. Antibody against human mucin core protein and method of preparing and using same
ATE243754T1 (de) * 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
EP0491867B1 (en) * 1989-09-15 1996-11-27 Genetic Systems Corporation Hybridoma ct43 producing a monoclonal antibody to a mucin epitope of colorectal cancer
US5165922A (en) * 1990-05-22 1992-11-24 Bristol-Myers Squibb Company Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy
JPH06501620A (ja) 1990-11-06 1994-02-24 ザ・チルドレンズ・メディカル・センター・コーポレイション 可溶性マンノース受容体ペプチド
GB9117522D0 (en) 1991-08-14 1991-10-02 Medical Res Council Ligands for dendritic cells, their uses and production
DE4133791A1 (de) * 1991-10-11 1993-04-15 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung
AU8068694A (en) * 1993-11-04 1995-05-23 Canterbury Health Limited Dendritic cell-specific antibodies and methods for their preparation
WO1995015340A1 (en) * 1993-12-03 1995-06-08 The Board Of Trustees Of Leland Stanford Junior University Monoclonal antibodies to antigens expressed by human dendritic cells
AU716056B2 (en) 1995-01-31 2000-02-17 Rockefeller University, The Identification of DEC, (dentritic and epithelial cells, 205 kDa), a receptor with C-type lectin domains, nucleic acids encoding DEC, and uses thereof
US20020187131A1 (en) * 1995-01-31 2002-12-12 Daniel Hawiger Enhanced antigen delivery and modulation of the immune response therefrom
US5773292A (en) * 1995-06-05 1998-06-30 Cornell University Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
US5869057A (en) * 1995-06-07 1999-02-09 Rock; Edwin P. Recombinant vaccines to break self-tolerance
US6080409A (en) * 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
EP1015489B1 (en) 1996-05-29 2006-07-05 Derek Nigel John Hart Dendritic cell receptor
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
WO1998015579A1 (en) * 1996-10-09 1998-04-16 Canterbury Health Limited Dendritic cell-specific antibodies
AR014891A1 (es) 1997-07-09 2001-04-11 Schering Corp Genes aislados de proteinas de membranas de mamiferos; reactivos relacionados
DK1027063T3 (da) 1997-09-29 2009-06-02 Macfarlane Burnet Inst For Med Mannosereceptorbærende cellelinje og antigensammensætning
AU1457199A (en) 1997-11-12 1999-05-31 University Of Pittsburgh Isolation, characterization, and identification of dendritic like cells and methods of using same
JP2002506645A (ja) 1998-03-17 2002-03-05 シェーリング コーポレイション 単離された哺乳動物膜タンパク質遺伝子および関連試薬
WO1999055369A1 (en) * 1998-04-28 1999-11-04 Smithkline Beecham Corporation Monoclonal antibodies with reduced immunogenicity
EP1078060B1 (en) 1998-05-11 2007-01-10 E.P. Prof. Dr. Rieber Antibodies to dendritic cells and human dendritic cell populations and uses thereof
WO2000000156A2 (en) 1998-06-26 2000-01-06 Trustees Of Dartmouth College Methods for modulating immunological responses by targeting antigen to apcs in conjuction with anti-cd40 ligands
KR100295558B1 (ko) 1998-06-27 2001-07-12 김기태 1차면역세포들중덴드리틱세포(dendriticcell)표면에특이하게작용하는단클론항체3-6-a
EP0997476A3 (en) 1998-09-25 2000-07-19 Schering-Plough Antibodies to a mammalian Langerhans cell antigen and their uses
EP1046651A1 (en) * 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
ATE553131T1 (de) 2000-05-08 2012-04-15 Celldex Res Corp Humane monoklonale antikörper gegen dendritische zellen

Similar Documents

Publication Publication Date Title
JP2003532409A5 (https=)
US11981733B2 (en) LAG-3 antibody, antigen-binding fragment thereof, and pharmaceutical application thereof
US20230303718A1 (en) Modified Antibody
JP2008543339A5 (https=)
KR100483494B1 (ko) 감마 인터페론에 대한 인간화 항체
JP3665316B2 (ja) 抗ｔｒａｉｌ−ｒ抗体
CN1518458B (zh) 移植物排斥反应抑制剂
JP2020528768A5 (https=)
JP2005508176A5 (https=)
KR20210032311A (ko) Cd19에 결합하는 중쇄 항체
JP2012526558A5 (https=)
CZ292295B6 (cs) Rekombinantní protilátková molekula, DNA sekvence, terapeutická nebo diagnostická kompozice a použití protilátkové molekuly
RU2011110169A (ru) Антитела против ccr2
CN1344275A (zh) 用淀粉样蛋白抗体除去淀粉样蛋白的方法
HRP20120701T1 (hr) Humana monoklonska protutijela protiv fukozil-gm1 i postupci za uporabu antifukozil-gm1
CN111683966A (zh) 与cd22结合的重链抗体
TW200416044A (en) Humanized anti-lymphotoxin β receptor antibodies
Couto et al. Anti-BA46 monoclonal antibody Mc3: humanization using a novel positional consensus and in vivo and in vitro characterization
KR20240099351A (ko) Gprc5d에 결합하는 항체 및 그 용도
CN121263449A (zh) Cd19/cd38多特异性抗体
CN104829716A (zh) 用于治疗疾病的抗人sema4A抗体
US20030180799A1 (en) Antibodies against plasma cells
KR100250832B1 (ko) 비형 간염 바이러스의 표면 항원 프리-에스1 에피토프를 인식하는 생쥐 단일클론항체의 가변 영역,이를 암호하는 유전자 및 그의 염기 서열
WO2023232023A1 (en) Molecules binding pd-l1 and uses thereof
Scheinberg et al. Radioimmunotherapy in experimental animal models: principles derived from models