JP2003531857A5 - - Google Patents
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- JP2003531857A5 JP2003531857A5 JP2001579803A JP2001579803A JP2003531857A5 JP 2003531857 A5 JP2003531857 A5 JP 2003531857A5 JP 2001579803 A JP2001579803 A JP 2001579803A JP 2001579803 A JP2001579803 A JP 2001579803A JP 2003531857 A5 JP2003531857 A5 JP 2003531857A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- day
- medium
- use according
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 description 21
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 10
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 229940057917 medium chain triglycerides Drugs 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 230000003920 cognitive function Effects 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 235000015897 energy drink Nutrition 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000004140 ketosis Effects 0.000 description 1
- 201000010901 lateral sclerosis Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000005264 motor neuron disease Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20098000P | 2000-05-01 | 2000-05-01 | |
| US60/200,980 | 2000-05-01 | ||
| PCT/US2001/013955 WO2001082928A1 (en) | 2000-05-01 | 2001-05-01 | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012105692A Division JP5701245B2 (ja) | 2000-05-01 | 2012-05-07 | アルツハイマー病およびニューロンの代謝の減少によって引き起こされる他の病気を治療および予防するための中鎖トリグリセリドの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003531857A JP2003531857A (ja) | 2003-10-28 |
| JP2003531857A5 true JP2003531857A5 (https=) | 2008-03-13 |
Family
ID=22743976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001579803A Pending JP2003531857A (ja) | 2000-05-01 | 2001-05-01 | アルツハイマー病およびニューロンの代謝の減少によって引き起こされる他の病気を治療および予防するための中鎖トリグリセリドの使用 |
| JP2012105692A Expired - Lifetime JP5701245B2 (ja) | 2000-05-01 | 2012-05-07 | アルツハイマー病およびニューロンの代謝の減少によって引き起こされる他の病気を治療および予防するための中鎖トリグリセリドの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012105692A Expired - Lifetime JP5701245B2 (ja) | 2000-05-01 | 2012-05-07 | アルツハイマー病およびニューロンの代謝の減少によって引き起こされる他の病気を治療および予防するための中鎖トリグリセリドの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20020006959A1 (https=) |
| EP (3) | EP1292294B1 (https=) |
| JP (2) | JP2003531857A (https=) |
| AT (1) | ATE425750T1 (https=) |
| AU (1) | AU2001257451A1 (https=) |
| DE (1) | DE60138019D1 (https=) |
| DK (1) | DK1292294T3 (https=) |
| ES (2) | ES2752800T3 (https=) |
| PT (1) | PT1292294E (https=) |
| WO (1) | WO2001082928A1 (https=) |
Families Citing this family (102)
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| US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
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| US20080009467A1 (en) * | 2000-05-01 | 2008-01-10 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism |
| US20070179197A1 (en) * | 2000-05-01 | 2007-08-02 | Accera, Inc. | Compositions and methods for improving or preserving brain function |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| WO2007115282A2 (en) * | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
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| GB0306394D0 (en) | 2003-03-20 | 2003-04-23 | Univ Nottingham | Carnitine retention |
| EP1648952B1 (en) | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| GB0420856D0 (en) * | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
| EP1778615A4 (en) | 2004-07-20 | 2010-01-06 | Btg Int Ltd | OLIGOMERE KETONE COMPOUNDS |
| ES2574557T3 (es) * | 2004-09-21 | 2016-06-20 | Btg International Limited | Miméticos dopaminérgicos |
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-
2001
- 2001-05-01 AU AU2001257451A patent/AU2001257451A1/en not_active Abandoned
- 2001-05-01 PT PT01930965T patent/PT1292294E/pt unknown
- 2001-05-01 EP EP01930965A patent/EP1292294B1/en not_active Expired - Lifetime
- 2001-05-01 AT AT01930965T patent/ATE425750T1/de active
- 2001-05-01 ES ES09001380T patent/ES2752800T3/es not_active Expired - Lifetime
- 2001-05-01 EP EP09001380.6A patent/EP2065041B1/en not_active Expired - Lifetime
- 2001-05-01 JP JP2001579803A patent/JP2003531857A/ja active Pending
- 2001-05-01 US US09/845,741 patent/US20020006959A1/en not_active Abandoned
- 2001-05-01 EP EP10181854A patent/EP2319508A1/en not_active Withdrawn
- 2001-05-01 ES ES01930965T patent/ES2323940T3/es not_active Expired - Lifetime
- 2001-05-01 DE DE60138019T patent/DE60138019D1/de not_active Expired - Lifetime
- 2001-05-01 DK DK01930965T patent/DK1292294T3/da active
- 2001-05-01 WO PCT/US2001/013955 patent/WO2001082928A1/en not_active Ceased
-
2006
- 2006-01-13 US US11/331,673 patent/US20060122270A1/en not_active Abandoned
-
2012
- 2012-04-12 US US13/445,679 patent/US8426468B2/en not_active Expired - Fee Related
- 2012-05-07 JP JP2012105692A patent/JP5701245B2/ja not_active Expired - Lifetime
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