JP2003528871A5 - - Google Patents

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Publication number
JP2003528871A5
JP2003528871A5 JP2001570654A JP2001570654A JP2003528871A5 JP 2003528871 A5 JP2003528871 A5 JP 2003528871A5 JP 2001570654 A JP2001570654 A JP 2001570654A JP 2001570654 A JP2001570654 A JP 2001570654A JP 2003528871 A5 JP2003528871 A5 JP 2003528871A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halo
independently hydrogen
pyrrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2001570654A
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English (en)
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JP2003528871A (ja
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Publication date
Priority claimed from US09/814,787 external-priority patent/US6525051B2/en
Application filed filed Critical
Publication of JP2003528871A publication Critical patent/JP2003528871A/ja
Publication of JP2003528871A5 publication Critical patent/JP2003528871A5/ja
Ceased legal-status Critical Current

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Description

個々のR1及びR3は独立して、水素、ハロ、アルキル、ハロアルキル、ニトロ、アラルコキシ、-OR 8 , -R11-OR 8 , -N(R8)R9, -C(O)OR8, -R11-C(O)OR8, -C(O)N(R8)R9, -R11-C(O)N(R8)R9, -C(O)N(R8)CH2C(O)N(R8)R9, -N(R8)C(O)N(R8)R9, -N(R8)C(O)R9, -N(R8)S(O)2R10及び-N(R8)C(O)N(R8)-CH2C(O)N(R8)R9から成る群から選択され；
R2は、水素、アルキル、ブロモ、ヨード、-N(R7)-(CH2)p-N(R8)R9（ここでｐは１〜４）である）、-(CH2)q-N(R7)-CH2-C(O)-OR8（ここでｑは０〜３である）、４−モルホリニル、１−ピペリジニル、１−ピペラジニル又は１−ピロリジニルであり；
個々のR4は独立して、水素又はアルキルであり；
個々のR5は独立して、水素、ハロ、ハロアルキル、アルキル、ニトロ、-OR8, -C(O)OR8, -C(O)N(R8)R9, -N(R8)R9, -N(R8)C(O)R8又は-N(H)S(O)2R10であり；
個々のR6は独立して、水素、アルキル、アリール、アラルキル、ハロ、-N(R8)R9, -N(R7)-(CH2)p-N(R8)R9（ここでｐは１〜４である）、-(CH2)q-N(R7)-CH2-C(O)OR8（ここでｑは０〜３である）、４−モルホリニル、１−ピペリジニル、１−ピペラジニル又は１−ピロリジニルであり；
個々のR7は、水素又はアルキルである；
R2が、水素、アルキル、ブロモ、ヨード、-N(R7)-(CH2)p-N(R8)R9（ここでｐは１〜４である）、-(CH2)q-N(R7)-CH2-C(O)-OR8（ここでｑは０〜３である）、４−モルホリニル、１−ピペリジニル、１−ピペラジニル又は１−ピロリジニルであり；
R4が、水素又はアルキルであり；
R5が、水素、ハロ、ハロアルキル、アルキル、ニトロ、-OR8, -C(O)OR8, -C(O)N(R8)R9, -N(R8)R9, -N(R8)C(O)R8又は-N(H)S(O)2R10であり；
個々のR7が、水素又はアルキルであり；そして
個々のR8及びR9が独立して、水素又はアルキルであるそのサブグループの化合物である。
JP2001570654A 2000-03-27 2001-03-26 Ｎｏｓインヒビターとしてのｎ−複素環式誘導体 Ceased JP2003528871A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19216800P 2000-03-27 2000-03-27
US60/192,168 2000-03-27
US09/814,787 US6525051B2 (en) 2000-03-27 2001-03-22 N-heterocyclic derivatives as NOS inhibitors
US09/814,787 2001-03-22
PCT/US2001/009481 WO2001072744A1 (en) 2000-03-27 2001-03-26 N-heterocyclic derivatives as nos inhibitors

Publications (2)

Publication Number Publication Date
JP2003528871A JP2003528871A (ja) 2003-09-30
JP2003528871A5 true JP2003528871A5 (ja) 2011-12-15

Family

ID=26887800

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001570654A Ceased JP2003528871A (ja) 2000-03-27 2001-03-26 Ｎｏｓインヒビターとしてのｎ−複素環式誘導体

Country Status (13)

Country Link
US (1) US6525051B2 (ja)
EP (1) EP1268471B1 (ja)
JP (1) JP2003528871A (ja)
AT (1) ATE252097T1 (ja)
AU (1) AU2001245972A1 (ja)
DE (1) DE60101000T2 (ja)
DK (1) DK1268471T3 (ja)
ES (1) ES2208578T3 (ja)
HK (1) HK1053834A1 (ja)
NO (1) NO20024614L (ja)
PT (1) PT1268471E (ja)
TR (1) TR200302268T4 (ja)
WO (1) WO2001072744A1 (ja)

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MXPA05001096A (es) * 2002-07-29 2005-11-23 Rigel Pharmaceuticals Inc Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina.
WO2004056807A1 (en) 2002-12-20 2004-07-08 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
US7109337B2 (en) 2002-12-20 2006-09-19 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
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JP2007537235A (ja) 2004-05-14 2007-12-20 ファイザー・プロダクツ・インク 異常細胞増殖の治療用ピリミジン誘導体
MXPA06013165A (es) 2004-05-14 2007-02-13 Pfizer Prod Inc Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
EP1751142A1 (en) 2004-05-14 2007-02-14 Pfizer Products Incorporated Pyrimidines derivatives for the treatment of abnormal cell growth
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CA2584295C (en) * 2004-11-24 2014-08-26 Rigel Pharmaceuticals, Inc. Spiro-2, 4-pyrimidinediamine compounds and their uses
ES2440965T3 (es) * 2005-01-14 2014-01-31 Chemocentryx, Inc. Heteroaril-sulfonamidas y CCR2
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
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PT2323993E (pt) 2008-04-16 2015-10-12 Portola Pharm Inc 2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
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