JP2003528614A5 - - Google Patents

Info

Publication number

JP2003528614A5

JP2003528614A5 JP2001570795A JP2001570795A JP2003528614A5 JP 2003528614 A5 JP2003528614 A5 JP 2003528614A5 JP 2001570795 A JP2001570795 A JP 2001570795A JP 2001570795 A JP2001570795 A JP 2001570795A JP 2003528614 A5 JP2003528614 A5 JP 2003528614A5

Authority

JP

Japan

Prior art keywords

nucleic acid

seq

processing component

antigenic polypeptide

processing

Prior art date

2001-03-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 102000039446 nucleic acids Human genes 0.000 description 16
• 108020004707 nucleic acids Proteins 0.000 description 16
• 150000007523 nucleic acids Chemical class 0.000 description 16
• 108090000765 processed proteins & peptides Proteins 0.000 description 15
• 230000000890 antigenic effect Effects 0.000 description 11
• 229920001184 polypeptide Polymers 0.000 description 11
• 102000004196 processed proteins & peptides Human genes 0.000 description 11
• 210000004027 cell Anatomy 0.000 description 5
• 239000002773 nucleotide Substances 0.000 description 5
• 125000003729 nucleotide group Chemical group 0.000 description 5
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 4
• 125000003275 alpha amino acid group Chemical group 0.000 description 3
• 108020001507 fusion proteins Proteins 0.000 description 3
• 102000037865 fusion proteins Human genes 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 241000724675 Hepatitis E virus Species 0.000 description 2
• 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 229940023146 nucleic acid vaccine Drugs 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 230000003612 virological effect Effects 0.000 description 2
• 210000000612 antigen-presenting cell Anatomy 0.000 description 1
• 210000000234 capsid Anatomy 0.000 description 1
• 210000000172 cytosol Anatomy 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 230000004044 response Effects 0.000 description 1
• 230000004960 subcellular localization Effects 0.000 description 1