JP2003527822A - ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ - Google Patents
ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼInfo
- Publication number
- JP2003527822A JP2003527822A JP2000567712A JP2000567712A JP2003527822A JP 2003527822 A JP2003527822 A JP 2003527822A JP 2000567712 A JP2000567712 A JP 2000567712A JP 2000567712 A JP2000567712 A JP 2000567712A JP 2003527822 A JP2003527822 A JP 2003527822A
- Authority
- JP
- Japan
- Prior art keywords
- heparinase
- modified
- heparin
- seq
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9815398P | 1998-08-27 | 1998-08-27 | |
| US60/098,153 | 1998-08-27 | ||
| PCT/US1999/019841 WO2000012726A2 (en) | 1998-08-27 | 1999-08-27 | Rationally designed heparinases derived from heparinase i and ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527822A true JP2003527822A (ja) | 2003-09-24 |
| JP2003527822A5 JP2003527822A5 (https=) | 2006-10-19 |
Family
ID=22267548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567712A Pending JP2003527822A (ja) | 1998-08-27 | 1999-08-27 | ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7560106B2 (https=) |
| EP (1) | EP1109919A2 (https=) |
| JP (1) | JP2003527822A (https=) |
| CA (1) | CA2341412A1 (https=) |
| WO (1) | WO2000012726A2 (https=) |
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| JP2003527822A (ja) | 1998-08-27 | 2003-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| CA2370539C (en) * | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
| US6979563B1 (en) * | 1999-11-17 | 2005-12-27 | Biomarin Enzymes, Inc. | Attenuation of tumor growth, metastasis and angiogenesis |
| CA2402160C (en) | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| DE60138115D1 (de) | 2000-09-12 | 2009-05-07 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2002224408B2 (en) | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| CA2484604C (en) * | 2002-05-03 | 2011-08-02 | Massachusetts Institute Of Technology | .delta. 4,5 glycuronidase and uses thereof |
| EP2301564A1 (en) | 2002-05-04 | 2011-03-30 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| JP4657726B2 (ja) | 2002-05-20 | 2011-03-23 | マサチューセッツ インスティテュート オブ テクノロジー | Ｎｍｒを使用する配列決定のための新規方法 |
| US20060153827A1 (en) * | 2002-08-15 | 2006-07-13 | Gruskin Elliott A | Chimeric protein |
| JP4606712B2 (ja) | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | ２−ｏスルファターゼ組成物および関連の方法 |
| EP3514238B1 (en) | 2003-05-16 | 2021-05-05 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| JP4754492B2 (ja) * | 2003-05-16 | 2011-08-24 | アコーダ セラピューティクス、インク． | 中枢神経系障害を治療するための組成物および方法 |
| EP1737954A2 (en) | 2004-03-10 | 2007-01-03 | The Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
| US20060057638A1 (en) | 2004-04-15 | 2006-03-16 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US8226941B2 (en) * | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
| EP1768687A2 (en) | 2004-06-29 | 2007-04-04 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
| US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| JP5189985B2 (ja) | 2005-09-26 | 2013-04-24 | アコーダ セラピューティクス、インク． | コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法 |
| US7691613B2 (en) | 2006-11-03 | 2010-04-06 | Momenta Pharmaceuticals, Inc. | Glycosaminoglycan lyase IV and uses thereof |
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-
1999
- 1999-08-27 JP JP2000567712A patent/JP2003527822A/ja active Pending
- 1999-08-27 EP EP99945315A patent/EP1109919A2/en not_active Withdrawn
- 1999-08-27 CA CA002341412A patent/CA2341412A1/en not_active Abandoned
- 1999-08-27 WO PCT/US1999/019841 patent/WO2000012726A2/en not_active Ceased
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2005
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2006
- 2006-12-20 US US11/643,631 patent/US20070148158A1/en not_active Abandoned
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| EP1109919A2 (en) | 2001-06-27 |
| WO2000012726A3 (en) | 2000-06-29 |
| US7560106B2 (en) | 2009-07-14 |
| WO2000012726A2 (en) | 2000-03-09 |
| CA2341412A1 (en) | 2000-03-09 |
| US20060105430A1 (en) | 2006-05-18 |
| US20070148158A1 (en) | 2007-06-28 |
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