CA2341412A1 - Rationally designed heparinases derived from heparinase i and ii - Google Patents
Rationally designed heparinases derived from heparinase i and ii Download PDFInfo
- Publication number
- CA2341412A1 CA2341412A1 CA002341412A CA2341412A CA2341412A1 CA 2341412 A1 CA2341412 A1 CA 2341412A1 CA 002341412 A CA002341412 A CA 002341412A CA 2341412 A CA2341412 A CA 2341412A CA 2341412 A1 CA2341412 A1 CA 2341412A1
- Authority
- CA
- Canada
- Prior art keywords
- heparinase
- modified
- heparin
- seq
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9815398P | 1998-08-27 | 1998-08-27 | |
| US60/098,153 | 1998-08-27 | ||
| PCT/US1999/019841 WO2000012726A2 (en) | 1998-08-27 | 1999-08-27 | Rationally designed heparinases derived from heparinase i and ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2341412A1 true CA2341412A1 (en) | 2000-03-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341412A Abandoned CA2341412A1 (en) | 1998-08-27 | 1999-08-27 | Rationally designed heparinases derived from heparinase i and ii |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7560106B2 (https=) |
| EP (1) | EP1109919A2 (https=) |
| JP (1) | JP2003527822A (https=) |
| CA (1) | CA2341412A1 (https=) |
| WO (1) | WO2000012726A2 (https=) |
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| JP2003527822A (ja) | 1998-08-27 | 2003-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼiおよびii由来の合理的に設計されたヘパリナーゼ |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| CA2370539C (en) * | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
| US6979563B1 (en) * | 1999-11-17 | 2005-12-27 | Biomarin Enzymes, Inc. | Attenuation of tumor growth, metastasis and angiogenesis |
| CA2402160C (en) | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| DE60138115D1 (de) | 2000-09-12 | 2009-05-07 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2002224408B2 (en) | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| CA2484604C (en) * | 2002-05-03 | 2011-08-02 | Massachusetts Institute Of Technology | .delta. 4,5 glycuronidase and uses thereof |
| EP2301564A1 (en) | 2002-05-04 | 2011-03-30 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| JP4657726B2 (ja) | 2002-05-20 | 2011-03-23 | マサチューセッツ インスティテュート オブ テクノロジー | Nmrを使用する配列決定のための新規方法 |
| US20060153827A1 (en) * | 2002-08-15 | 2006-07-13 | Gruskin Elliott A | Chimeric protein |
| JP4606712B2 (ja) | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2−oスルファターゼ組成物および関連の方法 |
| EP3514238B1 (en) | 2003-05-16 | 2021-05-05 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| JP4754492B2 (ja) * | 2003-05-16 | 2011-08-24 | アコーダ セラピューティクス、インク. | 中枢神経系障害を治療するための組成物および方法 |
| EP1737954A2 (en) | 2004-03-10 | 2007-01-03 | The Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
| US20060057638A1 (en) | 2004-04-15 | 2006-03-16 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US8226941B2 (en) * | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
| EP1768687A2 (en) | 2004-06-29 | 2007-04-04 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
| US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| JP5189985B2 (ja) | 2005-09-26 | 2013-04-24 | アコーダ セラピューティクス、インク. | コンドロイチナーゼabci変異体を用いた組成物およびその使用方法 |
| US7691613B2 (en) | 2006-11-03 | 2010-04-06 | Momenta Pharmaceuticals, Inc. | Glycosaminoglycan lyase IV and uses thereof |
| US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| US7691612B2 (en) | 2005-11-03 | 2010-04-06 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| WO2007120478A2 (en) * | 2006-04-03 | 2007-10-25 | Massachusetts Institute Of Technology | Glycomic patterns for the detection of disease |
| US7722864B2 (en) | 2006-10-10 | 2010-05-25 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
| CA2674493C (en) | 2007-01-05 | 2017-05-09 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
| CN111304229A (zh) * | 2019-12-11 | 2020-06-19 | 泉州师范学院 | 一种肝素酶基因工程表达产物及其制备方法 |
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| US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
| US4443545A (en) * | 1980-08-25 | 1984-04-17 | Massachusetts Institute Of Technology | Process for producing heparinase |
| US4341869A (en) * | 1980-08-25 | 1982-07-27 | Massachusetts Institute Of Technology | Process for producing heparinase |
| US4373023A (en) * | 1980-10-14 | 1983-02-08 | Massachusetts Institute Of Technology | Process for neutralizing heparin |
| US4396762A (en) * | 1981-08-24 | 1983-08-02 | Massachusetts Institute Of Technology | Heparinase derived anticoagulants |
| US4551296A (en) | 1982-03-19 | 1985-11-05 | Allied Corporation | Producing high tenacity, high modulus crystalline article such as fiber or film |
| EP0114589B1 (en) | 1982-12-20 | 1987-09-23 | The President And Fellows Of Harvard College | Inhibition of angiogenesis |
| FR2553287B1 (fr) | 1983-10-18 | 1986-09-12 | Choay Sa | Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire |
| US4757056A (en) * | 1984-03-05 | 1988-07-12 | Hepar Industries, Inc. | Method for tumor regression in rats, mice and hamsters using hexuronyl hexosaminoglycan-containing compositions |
| DE3422518A1 (de) * | 1984-06-16 | 1985-12-19 | B. Braun Melsungen Ag, 3508 Melsungen | Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen |
| US5262403A (en) | 1986-03-10 | 1993-11-16 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II |
| DK196986D0 (da) | 1986-04-30 | 1986-04-30 | Novo Industri As | Fremstilling af polysaccharider |
| US5106734A (en) * | 1986-04-30 | 1992-04-21 | Novo Nordisk A/S | Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin |
| US4942156A (en) * | 1986-08-20 | 1990-07-17 | Hepar Industries, Inc. | Low molecular weight heparin derivatives having improved anti-Xa specificity |
| US4745105A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Low molecular weight heparin derivatives with improved permeability |
| US4830013A (en) * | 1987-01-30 | 1989-05-16 | Minnesota Mining And Manufacturing Co. | Intravascular blood parameter measurement system |
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| US5217705A (en) | 1987-09-25 | 1993-06-08 | Neorx Corporation | Method of diagnosing blood clots using fibrin-binding proteins |
| US5169772A (en) | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
| WO1989012692A1 (en) | 1988-06-06 | 1989-12-28 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase |
| IT1234508B (it) * | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| US5204323B1 (en) * | 1988-10-06 | 1995-07-18 | Ciba Geigy Corp | Hirudin antidotal compositions and methods |
| GB8826448D0 (en) | 1988-11-11 | 1988-12-14 | Thrombosis Res Inst | Improvements in/relating to organic compounds |
| JPH0693836B2 (ja) * | 1988-11-25 | 1994-11-24 | 新技術事業団 | バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法 |
| PT93847A (pt) | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| CA1340966C (en) * | 1989-05-19 | 2000-04-18 | Thomas R. Covey | Method of protein analysis |
| IT1237518B (it) | 1989-11-24 | 1993-06-08 | Renato Conti | Eparine supersolfatate |
| GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| US5152784A (en) * | 1989-12-14 | 1992-10-06 | Regents Of The University Of Minnesota | Prosthetic devices coated with a polypeptide with type IV collagen activity |
| IT1245761B (it) * | 1991-01-30 | 1994-10-14 | Alfa Wassermann Spa | Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. |
| JP3110064B2 (ja) * | 1991-03-06 | 2000-11-20 | 生化学工業株式会社 | 新規ヘパリチナーゼ、その製造法及びその生産菌 |
| US5262325A (en) | 1991-04-04 | 1993-11-16 | Ibex Technologies, Inc. | Method for the enzymatic neutralization of heparin |
| SK120193A3 (en) | 1991-05-02 | 1994-07-06 | Yeda Res & Dev | Pharmaceutical composition for the prevention and/or treatment of pathological processes |
| AU2561792A (en) | 1991-09-06 | 1993-04-05 | Children's Medical Center Corporation | Cell-type specific heparan sulfate proteoglycans and their uses |
| US5714376A (en) | 1991-10-23 | 1998-02-03 | Massachusetts Institute Of Technology | Heparinase gene from flavobacterium heparinum |
| EP0641438A1 (en) | 1991-11-21 | 1995-03-08 | Glyko, Inc. | Fluorophore-assisted therapeutic drug monitoring |
| GB9202019D0 (en) | 1992-01-30 | 1992-03-18 | Imperial College | Methods and apparatus for assay of sulphated polysaccharides |
| IT1254216B (it) | 1992-02-25 | 1995-09-14 | Opocrin Spa | Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| US5453171A (en) * | 1992-03-10 | 1995-09-26 | The Board Of Regents Of The University Of Michigan | Heparin-selective polymeric membrane electrode |
| US5856928A (en) * | 1992-03-13 | 1999-01-05 | Yan; Johnson F. | Gene and protein representation, characterization and interpretation process |
| GB9206291D0 (en) | 1992-03-23 | 1992-05-06 | Cancer Res Campaign Tech | Oligosaccharides having growth factor binding affinity |
| AU3938093A (en) | 1992-04-02 | 1993-11-08 | Baker Norton Pharmaceuticals, Inc. | Method and composition for treating antigen-induced and exercise-induced asthma |
| US5389539A (en) * | 1992-11-30 | 1995-02-14 | Massachusetts Institute Of Technology | Purification of heparinase I, II, and III from Flavobacterium heparinum |
| US5696100A (en) * | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
| GB9306255D0 (en) | 1993-03-25 | 1993-05-19 | Cancer Res Campaign Tech | Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity |
| FR2704861B1 (fr) * | 1993-05-07 | 1995-07-28 | Sanofi Elf | Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant. |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| CA2176934A1 (en) * | 1993-11-17 | 1995-05-26 | Ramnath Sasisekharan | Method for inhibiting angiogenesis using heparinase |
| US6013628A (en) * | 1994-02-28 | 2000-01-11 | Regents Of The University Of Minnesota | Method for treating conditions of the eye using polypeptides |
| US5607859A (en) * | 1994-03-28 | 1997-03-04 | Massachusetts Institute Of Technology | Methods and products for mass spectrometric molecular weight determination of polyionic analytes employing polyionic reagents |
| US5753445A (en) * | 1994-04-26 | 1998-05-19 | The Mount Sinai Medical Center Of The City University Of New York | Test for the detection of anti-heparin antibodies |
| AU2435795A (en) * | 1994-05-06 | 1995-11-29 | Glycomed Incorporated | O-desulfated heparin derivatives, methods of making and uses thereof |
| US5681733A (en) * | 1994-06-10 | 1997-10-28 | Ibex Technologies | Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum |
| US5619421A (en) * | 1994-06-17 | 1997-04-08 | Massachusetts Institute Of Technology | Computer-implemented process and computer system for estimating the three-dimensional shape of a ring-shaped molecule and of a portion of a molecule containing a ring-shaped structure |
| US5997863A (en) | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| FR2723847A1 (fr) * | 1994-08-29 | 1996-03-01 | Debiopharm Sa | Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques. |
| US5687090A (en) | 1994-09-01 | 1997-11-11 | Aspen Technology, Inc. | Polymer component characterization method and process simulation apparatus |
| JPH10509696A (ja) * | 1994-10-12 | 1998-09-22 | フォーカル, インコーポレイテッド | 生分解性ポリマーを介する標的化送達 |
| US5569366A (en) * | 1995-01-27 | 1996-10-29 | Beckman Instruments, Inc. | Fluorescent labelled carbohydrates and their analysis |
| US5618917A (en) * | 1995-02-15 | 1997-04-08 | Arch Development Corporation | Methods and compositions for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells |
| US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| JP3318578B2 (ja) * | 1995-05-26 | 2002-08-26 | サーモディックス,インコーポレイティド | 内皮化を促進するための方法及び移植用製品 |
| US5824299A (en) * | 1995-06-22 | 1998-10-20 | President & Fellows Of Harvard College | Modulation of endothelial cell proliferation with IP-10 |
| US5690910A (en) | 1995-08-18 | 1997-11-25 | Baker Norton Pharmaceuticals, Inc. | Method for treating asthma |
| JP3713276B2 (ja) | 1995-09-29 | 2005-11-09 | バイオマリン ファーマシューティカル インコーポレイテッド | 炎症反応の軽減のためのヘパリナーゼの使用 |
| US6217863B1 (en) * | 1995-10-30 | 2001-04-17 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase I |
| US5752019A (en) * | 1995-12-22 | 1998-05-12 | International Business Machines Corporation | System and method for confirmationally-flexible molecular identification |
| GB9606188D0 (en) | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| AU3892297A (en) | 1996-07-26 | 1998-02-20 | Ikonos Corporation | Sensor for detecting heparin and other analytes |
| ES2231880T3 (es) | 1996-07-29 | 2005-05-16 | Paringenix, Inc. | Procedimiento para tratar el asma con heparina o-desulfatada. |
| CA2266581C (en) | 1996-09-19 | 2007-03-13 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| US5759767A (en) * | 1996-10-11 | 1998-06-02 | Joseph R. Lakowicz | Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids |
| US6642360B2 (en) * | 1997-12-03 | 2003-11-04 | Genentech, Inc. | Secreted polypeptides that stimulate release of proteoglycans from cartilage |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| US6190875B1 (en) * | 1997-09-02 | 2001-02-20 | Insight Strategy & Marketing Ltd. | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
| US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
| US6268146B1 (en) * | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| JP2003527822A (ja) * | 1998-08-27 | 2003-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼiおよびii由来の合理的に設計されたヘパリナーゼ |
| US7056504B1 (en) * | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| US6291439B1 (en) * | 1998-09-02 | 2001-09-18 | Biomarin Pharmaceuticals | Methods for diagnosing atherosclerosis by measuring endogenous heparin and methods for treating atherosclerosis using heparin |
| US6333051B1 (en) | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
| CA2370539C (en) * | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
| CA2402160C (en) | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| DE60138115D1 (de) * | 2000-09-12 | 2009-05-07 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2002224408B2 (en) | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| WO2002077199A2 (en) | 2001-03-27 | 2002-10-03 | Massachusetts Institute Of Technology | Methods and products related to fgf dimerization |
| CA2484604C (en) * | 2002-05-03 | 2011-08-02 | Massachusetts Institute Of Technology | .delta. 4,5 glycuronidase and uses thereof |
| JP4657726B2 (ja) | 2002-05-20 | 2011-03-23 | マサチューセッツ インスティテュート オブ テクノロジー | Nmrを使用する配列決定のための新規方法 |
| DE60334220D1 (de) * | 2002-06-03 | 2010-10-28 | Massachusetts Inst Technology | Rationell konstruierte, von chondroitinase b abgeleitete lyasen |
| JP4606712B2 (ja) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2−oスルファターゼ組成物および関連の方法 |
| EP1737954A2 (en) * | 2004-03-10 | 2007-01-03 | The Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
| WO2005110438A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060057638A1 (en) * | 2004-04-15 | 2006-03-16 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| EP1768687A2 (en) * | 2004-06-29 | 2007-04-04 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
| US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| CA2594013A1 (en) * | 2005-01-12 | 2006-07-20 | Massachusetts Institute Of Technology | Methods and compositions related to modulating the extracellular stem cell environment |
| KR100965692B1 (ko) * | 2005-02-01 | 2010-06-24 | 삼성전자주식회사 | 이동통신 단말기의 부가서비스 상태를 표시하는 장치 및방법 |
| US20060183712A1 (en) * | 2005-02-17 | 2006-08-17 | The Texas A&M University System | Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor |
| US20090156477A1 (en) | 2005-03-29 | 2009-06-18 | Massachusetts Institute Of Technology | Compositions and Methods for Regulating Inflammatory Responses |
| WO2006105313A2 (en) | 2005-03-29 | 2006-10-05 | Massachusetts Institute Of Technology | Compositions of and methods of using oversulfated glycosaminoglycans |
| WO2007120478A2 (en) | 2006-04-03 | 2007-10-25 | Massachusetts Institute Of Technology | Glycomic patterns for the detection of disease |
-
1999
- 1999-08-27 JP JP2000567712A patent/JP2003527822A/ja active Pending
- 1999-08-27 EP EP99945315A patent/EP1109919A2/en not_active Withdrawn
- 1999-08-27 CA CA002341412A patent/CA2341412A1/en not_active Abandoned
- 1999-08-27 WO PCT/US1999/019841 patent/WO2000012726A2/en not_active Ceased
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2005
- 2005-07-27 US US11/191,144 patent/US7560106B2/en not_active Expired - Fee Related
-
2006
- 2006-12-20 US US11/643,631 patent/US20070148158A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1109919A2 (en) | 2001-06-27 |
| WO2000012726A3 (en) | 2000-06-29 |
| JP2003527822A (ja) | 2003-09-24 |
| US7560106B2 (en) | 2009-07-14 |
| WO2000012726A2 (en) | 2000-03-09 |
| US20060105430A1 (en) | 2006-05-18 |
| US20070148158A1 (en) | 2007-06-28 |
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