JP2003525945A5 - - Google Patents
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- Publication number
- JP2003525945A5 JP2003525945A5 JP2001565370A JP2001565370A JP2003525945A5 JP 2003525945 A5 JP2003525945 A5 JP 2003525945A5 JP 2001565370 A JP2001565370 A JP 2001565370A JP 2001565370 A JP2001565370 A JP 2001565370A JP 2003525945 A5 JP2003525945 A5 JP 2003525945A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- support
- mol
- alkyl
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 description 35
- 239000003153 chemical reaction reagent Substances 0.000 description 25
- 238000000034 method Methods 0.000 description 12
- 125000001424 substituent group Chemical group 0.000 description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 239000000178 monomer Substances 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000005466 alkylenyl group Chemical group 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 150000001282 organosilanes Chemical class 0.000 description 4
- -1 polypropylene Polymers 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 238000010532 solid phase synthesis reaction Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/521,552 | 2000-03-09 | ||
| US09/521,552 US6410643B1 (en) | 2000-03-09 | 2000-03-09 | Solid phase synthesis method and reagent |
| PCT/US2001/003780 WO2001066554A2 (en) | 2000-03-09 | 2001-02-06 | Solid phase synthesis method and reagent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003525945A JP2003525945A (ja) | 2003-09-02 |
| JP2003525945A5 true JP2003525945A5 (enExample) | 2008-03-27 |
| JP5048193B2 JP5048193B2 (ja) | 2012-10-17 |
Family
ID=24077178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001565370A Expired - Lifetime JP5048193B2 (ja) | 2000-03-09 | 2001-02-06 | 固相合成法及び試薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6410643B1 (enExample) |
| EP (1) | EP1268505B1 (enExample) |
| JP (1) | JP5048193B2 (enExample) |
| AT (1) | ATE323098T1 (enExample) |
| AU (1) | AU3484501A (enExample) |
| CA (1) | CA2399043C (enExample) |
| DE (1) | DE60118714T2 (enExample) |
| MX (1) | MXPA02007445A (enExample) |
| WO (1) | WO2001066554A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030099949A1 (en) * | 2001-10-05 | 2003-05-29 | Surmodics, Inc. | Arrays having clustered arrangements and methods of making and using |
| EP1394196A1 (en) * | 2002-08-16 | 2004-03-03 | Rohm And Haas Company | Resin for solid phase synthesis |
| EP1391465B1 (en) * | 2002-08-16 | 2008-07-09 | Rohm And Haas Company | Low void space resins and method of preparation |
| US20040063856A1 (en) * | 2002-09-30 | 2004-04-01 | Bohling James Charles | Resin for solid phase synthesis |
| EP1567569B1 (en) | 2002-11-29 | 2008-07-23 | Marcella Chiari | Method for immobilizing biologic molecules on solid surfaces |
| WO2004076511A2 (en) * | 2003-02-21 | 2004-09-10 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel surface coatings |
| US7309593B2 (en) * | 2003-10-01 | 2007-12-18 | Surmodics, Inc. | Attachment of molecules to surfaces |
| WO2005037338A1 (en) * | 2003-10-14 | 2005-04-28 | Cook Incorporated | Hydrophilic coated medical device |
| US20110059865A1 (en) | 2004-01-07 | 2011-03-10 | Mark Edward Brennan Smith | Modified Molecular Arrays |
| US20060018948A1 (en) * | 2004-06-24 | 2006-01-26 | Guire Patrick E | Biodegradable implantable medical devices, methods and systems |
| WO2006002366A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable ocular devices, methods and systems |
| US20060147847A1 (en) * | 2004-12-30 | 2006-07-06 | Guire Patrick E | Antimicrobial compositions and methods |
| EP1979023B1 (en) | 2006-01-17 | 2015-07-22 | Transcend Medical, Inc. | Glaucoma treatment device |
| US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| US8664463B2 (en) | 2010-10-06 | 2014-03-04 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Reversible adhesives |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| EP3785668A1 (en) | 2013-03-15 | 2021-03-03 | Alcon Inc. | Intraocular lens storage and loading devices and methods of use |
| CN103360807A (zh) * | 2013-07-01 | 2013-10-23 | 恒昌涂料（惠阳）有限公司 | 一种含氟光固化水性涂料及其制备方法 |
| ES2962463T3 (es) | 2015-06-10 | 2024-03-19 | Alcon Inc | Materiales y componentes de lentes intraoculares |
| EP3409695A4 (en) * | 2016-01-26 | 2019-10-16 | Kyoto University | LOW DENSITY GEL ARTICLES AND METHOD FOR PRODUCING A LOW DENSITY GEL ARTICLE |
| CN110494514A (zh) * | 2017-04-10 | 2019-11-22 | 默克专利有限公司 | 有机功能材料的制剂 |
| WO2020102583A1 (en) * | 2018-11-14 | 2020-05-22 | Synthomics, Inc. | Methods, devices, and systems for biopolymer synthesis |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1206457A (en) | 1981-10-07 | 1986-06-24 | Alan Rosevear | Synthesis of compounds |
| US5512329A (en) | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| US5217492A (en) | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
| US4722906A (en) | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
| US4705753A (en) * | 1984-06-08 | 1987-11-10 | Gregor Harry P | Biologically active acrylonitrile-based copolymeric membrane |
| US5296572A (en) | 1986-04-30 | 1994-03-22 | James Sparrow | Large pore polyamide resin and method of preparation thereof |
| US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
| NZ224284A (en) | 1987-04-24 | 1990-11-27 | Unilever Plc | Porous substrate containing gel for use in chemical synthesis, separation etc |
| DE4011084A1 (de) | 1990-04-05 | 1991-10-10 | Boehringer Mannheim Gmbh | Saccharid-modifizierte, wasserloesliche proteine |
| IT1252628B (it) | 1991-12-06 | 1995-06-19 | Pier Giorgio Righetti | Formulazioni per matrici poliacrilamidiche in metodiche elettrocinetiche |
| JP3455217B2 (ja) | 1992-02-13 | 2003-10-14 | バイオ−メトリック システムズ インコーポレイテッド | 架橋マトリックス中の化学種の固定 |
| JPH06130671A (ja) * | 1992-10-21 | 1994-05-13 | Mitsubishi Paper Mills Ltd | 平版印刷版 |
| US5414075A (en) | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
| US5221598A (en) | 1992-11-23 | 1993-06-22 | Eastman Kodak Company | Photographic support material comprising an antistatic layer and a heat-thickening barrier layer |
| DE69400177T2 (de) | 1993-02-05 | 1996-11-14 | Mitsubishi Paper Mills Ltd | Lithographische Druckplatte |
| US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| GB9406510D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Bump mapping in 3-d computer graphics |
| GB9406512D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Texture mapping in 3-d computer graphics |
| GB9406515D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Texture mapping for 3-d computer graphics |
| GB9406584D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Clipping in 3-d computer graphics |
| GB9406509D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Rendering 3-d scenes in computer graphics |
| GB9406511D0 (en) | 1994-03-31 | 1994-05-25 | Argonaut Software Limited | Z-buffering in 3-d computer graphics |
| WO1996037165A1 (en) | 1995-05-26 | 1996-11-28 | Bsi Corporation | Method and implantable article for promoting endothelialization |
| US5783502A (en) | 1995-06-07 | 1998-07-21 | Bsi Corporation | Virus inactivating coatings |
| US5785832A (en) | 1995-07-26 | 1998-07-28 | Chiari; Marcella | Covalently cross-linked, mixed-bed agarose-polyacrylamide matrices for electrophoresis and chromatography |
| IT1276957B1 (it) * | 1995-10-18 | 1997-11-03 | Pier Giorgio Righetti | Acrilamido derivati e formulazioni per matrici poliacrilamidiche in metodiche elettrocinetiche e cromatografiche |
| US5714360A (en) | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| US5765591A (en) | 1995-11-20 | 1998-06-16 | Argonaut Technologies, Inc. | Valve apparatus and method for distributing fluids |
| US5711607A (en) | 1995-12-04 | 1998-01-27 | Argonaut Technologies, Inc. | Temperature measurement technique with automatic verification of contact between probe and object |
| AU1834697A (en) | 1996-01-23 | 1997-08-20 | Argonaut Technologies, Inc. | Highly functionalized polyethylene glycol grafted polystyrene supports |
| US5942555A (en) | 1996-03-21 | 1999-08-24 | Surmodics, Inc. | Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom |
| AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| AUPO093296A0 (en) | 1996-07-10 | 1996-08-01 | University Of Melbourne, The | Electrophoresis gels and crosslinking agents for their preparation |
| US5806573A (en) | 1996-08-13 | 1998-09-15 | Argonaut Technologies Incorporated | Closure device and method for venting, cannulating and pressurizing a vessel |
| US6126904A (en) | 1997-03-07 | 2000-10-03 | Argonaut Technologies, Inc. | Apparatus and methods for the preparation of chemical compounds |
| WO1998041534A2 (en) | 1997-03-19 | 1998-09-24 | Biosepra Inc. | Multifunctional ceramic particles as supports for solid phase and combinatorial synthesis |
| US6190619B1 (en) | 1997-06-11 | 2001-02-20 | Argonaut Technologies, Inc. | Systems and methods for parallel synthesis of compounds |
| WO1999004895A1 (en) | 1997-07-24 | 1999-02-04 | Argonaut Technologies, Inc. | Compositions for the storage and delivery of solid phase reactive particles and methods of using the same |
| JP4330268B2 (ja) | 1997-09-03 | 2009-09-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 新規な生体模倣ヒドロゲル材料 |
| US5858653A (en) | 1997-09-30 | 1999-01-12 | Surmodics, Inc. | Reagent and method for attaching target molecules to a surface |
| US6465525B1 (en) | 1998-03-18 | 2002-10-15 | Surmodics, Inc. | Latent reactive blood compatible agents |
| JP2001206912A (ja) * | 2000-01-25 | 2001-07-31 | Oji Paper Co Ltd | 活性エネルギー線硬化重合体及びそれを用いたインクジェット記録シート |
-
2000
- 2000-03-09 US US09/521,552 patent/US6410643B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 AT AT01907009T patent/ATE323098T1/de not_active IP Right Cessation
- 2001-02-06 WO PCT/US2001/003780 patent/WO2001066554A2/en not_active Ceased
- 2001-02-06 EP EP01907009A patent/EP1268505B1/en not_active Expired - Lifetime
- 2001-02-06 DE DE60118714T patent/DE60118714T2/de not_active Expired - Lifetime
- 2001-02-06 MX MXPA02007445A patent/MXPA02007445A/es unknown
- 2001-02-06 CA CA2399043A patent/CA2399043C/en not_active Expired - Fee Related
- 2001-02-06 JP JP2001565370A patent/JP5048193B2/ja not_active Expired - Lifetime
- 2001-02-06 AU AU34845/01A patent/AU3484501A/en not_active Abandoned
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