JP2003525915A5 - - Google Patents
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- Publication number
- JP2003525915A5 JP2003525915A5 JP2001564805A JP2001564805A JP2003525915A5 JP 2003525915 A5 JP2003525915 A5 JP 2003525915A5 JP 2001564805 A JP2001564805 A JP 2001564805A JP 2001564805 A JP2001564805 A JP 2001564805A JP 2003525915 A5 JP2003525915 A5 JP 2003525915A5
- Authority
- JP
- Japan
- Prior art keywords
- embedded image
- group
- independently
- formula
- fifteen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 15
- 125000000217 alkyl group Chemical group 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- 238000002372 labelling Methods 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229930195733 hydrocarbon Natural products 0.000 description 4
- 150000002430 hydrocarbons Chemical class 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 0 CC*C(C1)(C1=C(C1(C)C)C=CC=CC=C(*2C*C)C(C)(C)c3c2ccc2c3C=CCC2)c2c1c(cccc1)c1cc2 Chemical compound CC*C(C1)(C1=C(C1(C)C)C=CC=CC=C(*2C*C)C(C)(C)c3c2ccc2c3C=CCC2)c2c1c(cccc1)c1cc2 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18668200P | 2000-03-03 | 2000-03-03 | |
| US60/186,682 | 2000-03-03 | ||
| PCT/US2001/006923 WO2001066153A1 (en) | 2000-03-03 | 2001-03-05 | Fluorescent membrane intercalating probes and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003525915A JP2003525915A (ja) | 2003-09-02 |
| JP2003525915A5 true JP2003525915A5 (https=) | 2008-04-24 |
Family
ID=22685883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001564805A Pending JP2003525915A (ja) | 2000-03-03 | 2001-03-05 | 蛍光膜インターカレーティングプローブおよびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7462347B2 (https=) |
| EP (1) | EP1265640B1 (https=) |
| JP (1) | JP2003525915A (https=) |
| AT (1) | ATE429932T1 (https=) |
| AU (2) | AU4542401A (https=) |
| CA (1) | CA2402352C (https=) |
| DE (1) | DE60138531D1 (https=) |
| WO (1) | WO2001066153A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4542401A (en) * | 2000-03-03 | 2001-09-17 | Phanos Tech Inc | Fluorescent membrane intercalating probes and methods for their use |
| AU2005234696B2 (en) * | 2005-11-18 | 2012-02-16 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| US20150223675A1 (en) * | 2012-09-04 | 2015-08-13 | Given Imaging Ltd. | Luminal administration of tag molecules for diagnostic applications |
| CA2901116C (en) * | 2012-09-05 | 2021-11-09 | Randall Thomas Irvin | Methods and composition for detecting intestinal cell-barrier dysfunction |
| US9034596B1 (en) | 2014-04-17 | 2015-05-19 | Kuwait University | Method for fluorescent staining of cellular and intracellular membranes |
| CN104098500B (zh) * | 2014-07-08 | 2016-03-16 | 中国科学院烟台海岸带研究所 | 基于花青的有机化合物及其应用 |
| US10663473B2 (en) | 2016-02-02 | 2020-05-26 | Maximus Diagnostic Technologies Llc | Method of identifying a status of a mucosal intestinal epithelial barrier to improve treatment of inflammatory bowel disease |
| US20210181185A1 (en) * | 2017-11-09 | 2021-06-17 | Mindimmune Therapeutics, Inc. | Dendritic cell recruitment from blood to brain in neurodegenerative disease |
| RU2665628C1 (ru) * | 2018-01-25 | 2018-09-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Устройство для спектрально-флуоресцентного исследования содержания флуорохромов |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| US4783401A (en) * | 1986-10-31 | 1988-11-08 | Smithkline Beckman Corporation | Viable cell labelling |
| US4859584A (en) * | 1986-10-31 | 1989-08-22 | Smithkline Beckman Corporation | Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes |
| JP3038339B2 (ja) * | 1988-05-02 | 2000-05-08 | ザイナクシス・テクノロジーズ・インコーポレーテッド | バイオ粒子の表面膜に対してバイオアフェクティング物質を結合する化合物 |
| KR100397020B1 (ko) * | 1995-01-30 | 2004-04-29 | 다이이치 가가쿠 야쿠힝 가부시키가이샤 | 진단용마커 |
| JP3669752B2 (ja) * | 1995-01-30 | 2005-07-13 | 第一化学薬品株式会社 | 診断用マーカー |
| US6004536A (en) * | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| US5804389A (en) * | 1995-12-29 | 1998-09-08 | Phanos Technologies, Inc. | Method for detecting abnormal epithelial cell shedding |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| AU4542401A (en) * | 2000-03-03 | 2001-09-17 | Phanos Tech Inc | Fluorescent membrane intercalating probes and methods for their use |
-
2001
- 2001-03-05 AU AU4542401A patent/AU4542401A/xx active Pending
- 2001-03-05 AT AT01918334T patent/ATE429932T1/de not_active IP Right Cessation
- 2001-03-05 JP JP2001564805A patent/JP2003525915A/ja active Pending
- 2001-03-05 WO PCT/US2001/006923 patent/WO2001066153A1/en not_active Ceased
- 2001-03-05 EP EP01918334A patent/EP1265640B1/en not_active Expired - Lifetime
- 2001-03-05 DE DE60138531T patent/DE60138531D1/de not_active Expired - Lifetime
- 2001-03-05 AU AU2001245424A patent/AU2001245424B2/en not_active Expired
- 2001-03-05 CA CA2402352A patent/CA2402352C/en not_active Expired - Lifetime
-
2006
- 2006-02-03 US US11/346,554 patent/US7462347B2/en not_active Expired - Lifetime
-
2008
- 2008-12-08 US US12/330,073 patent/US8029767B2/en not_active Expired - Fee Related
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