JP2003525915A5 - - Google Patents
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- JP2003525915A5 JP2003525915A5 JP2001564805A JP2001564805A JP2003525915A5 JP 2003525915 A5 JP2003525915 A5 JP 2003525915A5 JP 2001564805 A JP2001564805 A JP 2001564805A JP 2001564805 A JP2001564805 A JP 2001564805A JP 2003525915 A5 JP2003525915 A5 JP 2003525915A5
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- JP
- Japan
- Prior art keywords
- embedded image
- group
- independently
- formula
- fifteen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 15
- 125000000217 alkyl group Chemical group 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- 238000002372 labelling Methods 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229930195733 hydrocarbon Natural products 0.000 description 4
- 150000002430 hydrocarbons Chemical class 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 0 CC*C(C1)(C1=C(C1(C)C)C=CC=CC=C(*2C*C)C(C)(C)c3c2ccc2c3C=CCC2)c2c1c(cccc1)c1cc2 Chemical compound CC*C(C1)(C1=C(C1(C)C)C=CC=CC=C(*2C*C)C(C)(C)c3c2ccc2c3C=CCC2)c2c1c(cccc1)c1cc2 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18668200P | 2000-03-03 | 2000-03-03 | |
| US60/186,682 | 2000-03-03 | ||
| PCT/US2001/006923 WO2001066153A1 (en) | 2000-03-03 | 2001-03-05 | Fluorescent membrane intercalating probes and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003525915A JP2003525915A (ja) | 2003-09-02 |
| JP2003525915A5 true JP2003525915A5 (https=) | 2008-04-24 |
Family
ID=22685883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001564805A Pending JP2003525915A (ja) | 2000-03-03 | 2001-03-05 | 蛍光膜インターカレーティングプローブおよびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7462347B2 (https=) |
| EP (1) | EP1265640B1 (https=) |
| JP (1) | JP2003525915A (https=) |
| AT (1) | ATE429932T1 (https=) |
| AU (2) | AU2001245424B2 (https=) |
| CA (1) | CA2402352C (https=) |
| DE (1) | DE60138531D1 (https=) |
| WO (1) | WO2001066153A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001245424B2 (en) * | 2000-03-03 | 2005-08-18 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| AU2005234696B2 (en) * | 2005-11-18 | 2012-02-16 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| EP2892569B1 (en) * | 2012-09-04 | 2018-12-12 | Given Imaging Ltd. | Luminal administration of tag molecules for diagnostic applications |
| EP2893032B1 (en) * | 2012-09-05 | 2018-01-17 | Maximus Diagnostic Technologies LLC | Methods and composition for detecting intestinal cell-barrier dysfunction |
| US9034596B1 (en) | 2014-04-17 | 2015-05-19 | Kuwait University | Method for fluorescent staining of cellular and intracellular membranes |
| CN104098500B (zh) * | 2014-07-08 | 2016-03-16 | 中国科学院烟台海岸带研究所 | 基于花青的有机化合物及其应用 |
| JP2019508395A (ja) | 2016-02-02 | 2019-03-28 | マキシマス ダイアグノスティック テクノロジーズ エルエルシー | 炎症性腸疾患の処置を改善するための腸管バリア機能の評価 |
| CN111315869A (zh) * | 2017-11-09 | 2020-06-19 | 精神免疫疗法公司 | 神经退行性疾病中树突状细胞从血液募集到脑 |
| RU2665628C1 (ru) * | 2018-01-25 | 2018-09-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Устройство для спектрально-флуоресцентного исследования содержания флуорохромов |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859584A (en) * | 1986-10-31 | 1989-08-22 | Smithkline Beckman Corporation | Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes |
| US4783401A (en) * | 1986-10-31 | 1988-11-08 | Smithkline Beckman Corporation | Viable cell labelling |
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| ATE145337T1 (de) * | 1988-05-02 | 1996-12-15 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
| ATE264694T1 (de) * | 1995-01-30 | 2004-05-15 | Daiichi Pure Chemicals Co Ltd | Diagnostisches markierungsmittel |
| JP3669752B2 (ja) * | 1995-01-30 | 2005-07-13 | 第一化学薬品株式会社 | 診断用マーカー |
| US6004536A (en) * | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| US5804389A (en) * | 1995-12-29 | 1998-09-08 | Phanos Technologies, Inc. | Method for detecting abnormal epithelial cell shedding |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| AU2001245424B2 (en) * | 2000-03-03 | 2005-08-18 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
-
2001
- 2001-03-05 AU AU2001245424A patent/AU2001245424B2/en not_active Expired
- 2001-03-05 AU AU4542401A patent/AU4542401A/xx active Pending
- 2001-03-05 AT AT01918334T patent/ATE429932T1/de not_active IP Right Cessation
- 2001-03-05 WO PCT/US2001/006923 patent/WO2001066153A1/en not_active Ceased
- 2001-03-05 EP EP01918334A patent/EP1265640B1/en not_active Expired - Lifetime
- 2001-03-05 DE DE60138531T patent/DE60138531D1/de not_active Expired - Lifetime
- 2001-03-05 CA CA2402352A patent/CA2402352C/en not_active Expired - Lifetime
- 2001-03-05 JP JP2001564805A patent/JP2003525915A/ja active Pending
-
2006
- 2006-02-03 US US11/346,554 patent/US7462347B2/en not_active Expired - Lifetime
-
2008
- 2008-12-08 US US12/330,073 patent/US8029767B2/en not_active Expired - Fee Related
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