JP2003525915A - 蛍光膜インターカレーティングプローブおよびその使用方法 - Google Patents

蛍光膜インターカレーティングプローブおよびその使用方法

Info

Publication number
JP2003525915A
JP2003525915A JP2001564805A JP2001564805A JP2003525915A JP 2003525915 A JP2003525915 A JP 2003525915A JP 2001564805 A JP2001564805 A JP 2001564805A JP 2001564805 A JP2001564805 A JP 2001564805A JP 2003525915 A JP2003525915 A JP 2003525915A
Authority
JP
Japan
Prior art keywords
group
compound
independently
cells
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001564805A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003525915A5 (https=
Inventor
ブライアン・ディ・グレイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phanos Tech Inc
Original Assignee
Phanos Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phanos Tech Inc filed Critical Phanos Tech Inc
Publication of JP2003525915A publication Critical patent/JP2003525915A/ja
Publication of JP2003525915A5 publication Critical patent/JP2003525915A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0016—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
JP2001564805A 2000-03-03 2001-03-05 蛍光膜インターカレーティングプローブおよびその使用方法 Pending JP2003525915A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18668200P 2000-03-03 2000-03-03
US60/186,682 2000-03-03
PCT/US2001/006923 WO2001066153A1 (en) 2000-03-03 2001-03-05 Fluorescent membrane intercalating probes and methods for their use

Publications (2)

Publication Number Publication Date
JP2003525915A true JP2003525915A (ja) 2003-09-02
JP2003525915A5 JP2003525915A5 (https=) 2008-04-24

Family

ID=22685883

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001564805A Pending JP2003525915A (ja) 2000-03-03 2001-03-05 蛍光膜インターカレーティングプローブおよびその使用方法

Country Status (8)

Country Link
US (2) US7462347B2 (https=)
EP (1) EP1265640B1 (https=)
JP (1) JP2003525915A (https=)
AT (1) ATE429932T1 (https=)
AU (2) AU4542401A (https=)
CA (1) CA2402352C (https=)
DE (1) DE60138531D1 (https=)
WO (1) WO2001066153A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009524580A (ja) * 2005-11-18 2009-07-02 ファノス・テクノロジーズ・インコーポレイテッド 蛍光性膜インターカレート・プローブおよびその使用方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4542401A (en) * 2000-03-03 2001-09-17 Phanos Tech Inc Fluorescent membrane intercalating probes and methods for their use
US20150223675A1 (en) * 2012-09-04 2015-08-13 Given Imaging Ltd. Luminal administration of tag molecules for diagnostic applications
CA2901116C (en) * 2012-09-05 2021-11-09 Randall Thomas Irvin Methods and composition for detecting intestinal cell-barrier dysfunction
US9034596B1 (en) 2014-04-17 2015-05-19 Kuwait University Method for fluorescent staining of cellular and intracellular membranes
CN104098500B (zh) * 2014-07-08 2016-03-16 中国科学院烟台海岸带研究所 基于花青的有机化合物及其应用
US10663473B2 (en) 2016-02-02 2020-05-26 Maximus Diagnostic Technologies Llc Method of identifying a status of a mucosal intestinal epithelial barrier to improve treatment of inflammatory bowel disease
US20210181185A1 (en) * 2017-11-09 2021-06-17 Mindimmune Therapeutics, Inc. Dendritic cell recruitment from blood to brain in neurodegenerative disease
RU2665628C1 (ru) * 2018-01-25 2018-09-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Устройство для спектрально-флуоресцентного исследования содержания флуорохромов

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63122954A (ja) * 1986-10-31 1988-05-26 ファノス・テクノロジーズ・インコーポレイテッド 生育可能細胞の標識
JPS63122955A (ja) * 1986-10-31 1988-05-26 スミスクライン・ベックマン・コーポレイション 細胞増殖速度測定
JPS63126833A (ja) * 1986-10-31 1988-05-30 ファノス・テクノロジーズ・インコーポレイテッド ｉｎ　ｖｉｖｏ細胞追跡
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
JPH09299372A (ja) * 1995-12-29 1997-11-25 Fuanosu Deiberotsupumento:Kk 異常上皮細胞剥離の検出方法
WO1998030992A2 (en) * 1997-01-10 1998-07-16 Li-Cor, Inc. Fluorescent cyanine dyes
US6004536A (en) * 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3038339B2 (ja) * 1988-05-02 2000-05-08 ザイナクシス・テクノロジーズ・インコーポレーテッド バイオ粒子の表面膜に対してバイオアフェクティング物質を結合する化合物
KR100397020B1 (ko) * 1995-01-30 2004-04-29 다이이치 가가쿠 야쿠힝 가부시키가이샤 진단용마커
AU4542401A (en) * 2000-03-03 2001-09-17 Phanos Tech Inc Fluorescent membrane intercalating probes and methods for their use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63122954A (ja) * 1986-10-31 1988-05-26 ファノス・テクノロジーズ・インコーポレイテッド 生育可能細胞の標識
JPS63122955A (ja) * 1986-10-31 1988-05-26 スミスクライン・ベックマン・コーポレイション 細胞増殖速度測定
JPS63126833A (ja) * 1986-10-31 1988-05-30 ファノス・テクノロジーズ・インコーポレイテッド ｉｎ　ｖｉｖｏ細胞追跡
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
US6004536A (en) * 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
JPH09299372A (ja) * 1995-12-29 1997-11-25 Fuanosu Deiberotsupumento:Kk 異常上皮細胞剥離の検出方法
WO1998030992A2 (en) * 1997-01-10 1998-07-16 Li-Cor, Inc. Fluorescent cyanine dyes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009524580A (ja) * 2005-11-18 2009-07-02 ファノス・テクノロジーズ・インコーポレイテッド 蛍光性膜インターカレート・プローブおよびその使用方法
US8894976B2 (en) 2005-11-18 2014-11-25 Phanos Technologies, Inc. Fluorescent membrane intercalating probes and methods for their use
US9597416B2 (en) 2005-11-18 2017-03-21 Phanos Technologies, Inc. Fluorescent membrane intercalating probes and methods for their use

Also Published As

Publication number Publication date
DE60138531D1 (de) 2009-06-10
WO2001066153A1 (en) 2001-09-13
US8029767B2 (en) 2011-10-04
US20100003196A1 (en) 2010-01-07
AU4542401A (en) 2001-09-17
EP1265640B1 (en) 2009-04-29
AU2001245424B2 (en) 2005-08-18
EP1265640A4 (en) 2003-07-09
CA2402352C (en) 2012-08-28
US7462347B2 (en) 2008-12-09
ATE429932T1 (de) 2009-05-15
US20060193780A1 (en) 2006-08-31
EP1265640A1 (en) 2002-12-18
CA2402352A1 (en) 2001-09-13

Similar Documents

Publication Publication Date Title
US9597416B2 (en) Fluorescent membrane intercalating probes and methods for their use
US8029767B2 (en) Fluorescent membrane intercalating probes and methods for their use
CN108440475B (zh) 一种区分不同极性脂滴的比率型荧光探针及其制备方法和应用
TWI499427B (zh) Fluorescent probes for imaging lymph nodes
WO2023087169A1 (zh) 两种前列腺特异性膜抗原靶向荧光探针及其制备方法与应用
KR20230058122A (ko) 종양 조영 화합물, 이의 제조 방법 및 종양 진단 이미징에서의 응용
CA3177944A1 (en) Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
CN121443611A (zh) 用于肿瘤靶向成像的荧光探针化合物及其合成方法和应用
AU2001245424A1 (en) Fluorescent membrane intercalating probes and methods for their use
US8916137B2 (en) Monofunctional carbocyanine dyes for in vivo and in vitro imaging
US20220163545A1 (en) Reagent for fluorescence imaging of lipid droplets in cell and tissue
CN105061515A (zh) 一种磷光铱配合物的合成及其用于血吸虫尾蚴荧光标记
CN113563298B (zh) 一类含水溶性取代基罗丹明荧光染料其制备方法和应用
US20030223935A1 (en) Fluorescent membrane intercalating probes and methods for their use
JP7537194B2 (ja) 蛍光標識剤およびフタロシアニン
WO2021177060A1 (ja) Ｌｔａ１基質となる蛍光プローブ
CN112851575B (zh) 具有聚集诱导发光性质的比率型溶酶体pH探针及应用
CN114058369B (zh) 基于苯乙烯噁唑酮类化合物的荧光探针及其生物应用
WO2023074778A1 (ja) 細胞および組織内脂質滴の蛍光イメージング試薬

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080305

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080305

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110719

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110927

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111018

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111025

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111213