JP2003523959A - カプセル化及び非カプセル化薬剤の為の固体送達システムを調製する方法 - Google Patents
カプセル化及び非カプセル化薬剤の為の固体送達システムを調製する方法Info
- Publication number
- JP2003523959A JP2003523959A JP2001549640A JP2001549640A JP2003523959A JP 2003523959 A JP2003523959 A JP 2003523959A JP 2001549640 A JP2001549640 A JP 2001549640A JP 2001549640 A JP2001549640 A JP 2001549640A JP 2003523959 A JP2003523959 A JP 2003523959A
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- Prior art keywords
- lipid
- suspension
- delivery system
- drug
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/476,483 | 1999-12-30 | ||
| US09/476,483 US6340471B1 (en) | 1999-12-30 | 1999-12-30 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US09/656,297 | 2000-09-06 | ||
| US09/656,297 US6541025B1 (en) | 1999-12-30 | 2000-09-06 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| PCT/US2000/034776 WO2001049272A2 (en) | 1999-12-30 | 2000-12-20 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523959A true JP2003523959A (ja) | 2003-08-12 |
| JP2003523959A5 JP2003523959A5 (https=) | 2008-02-14 |
Family
ID=27045193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549640A Pending JP2003523959A (ja) | 1999-12-30 | 2000-12-20 | カプセル化及び非カプセル化薬剤の為の固体送達システムを調製する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6541025B1 (https=) |
| EP (1) | EP1246615B1 (https=) |
| JP (1) | JP2003523959A (https=) |
| AU (1) | AU780136B2 (https=) |
| CA (1) | CA2392621C (https=) |
| WO (1) | WO2001049272A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US7067148B2 (en) | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| SE0200154D0 (sv) * | 2002-01-21 | 2002-01-21 | Galenica Ab | New process |
| US20030190343A1 (en) * | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
| CO5400144A1 (es) * | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
| US20040096498A1 (en) * | 2002-04-29 | 2004-05-20 | Alvin Kershman | Oral pharmaceutical delivery system with improved sustained release |
| US20030235613A1 (en) * | 2002-06-19 | 2003-12-25 | Cts Chemical Industries Ltd. | Popping oral administration form |
| EP1759692A3 (en) * | 2003-03-10 | 2007-09-12 | Novartis AG | Taste-masked solid veterinary compositions |
| US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| US20070122488A1 (en) * | 2004-02-25 | 2007-05-31 | Erich Windhab | Multi-functional microcapsules and method and device for manufacturing same |
| US8075910B2 (en) * | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| US20060067954A1 (en) * | 2004-09-24 | 2006-03-30 | Cottrell Ian W | Lipid stabilized formulations |
| US7956235B2 (en) * | 2004-12-29 | 2011-06-07 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a temperature change member |
| US8129582B2 (en) * | 2004-12-29 | 2012-03-06 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a temperature change member |
| US20060142716A1 (en) * | 2004-12-29 | 2006-06-29 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a non-abrasive temperature change member |
| US8318210B2 (en) | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US8486452B2 (en) | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| US8110226B2 (en) * | 2007-07-20 | 2012-02-07 | Mylan Pharmaceuticals Inc. | Drug formulations having inert sealed cores |
| GB0807605D0 (en) | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| EP3064064A1 (en) * | 2009-09-30 | 2016-09-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
| ES2699806T3 (es) | 2012-04-18 | 2019-02-12 | SpecGx LLC | Composiciones farmacéuticas, disuasivas del abuso, de liberación inmediata |
| BR112015000320B1 (pt) | 2012-07-12 | 2023-03-07 | SpecGx LLC | Composições farmacêuticas dissuasivas de abuso e seu processo de preparação |
| CN104936581A (zh) * | 2012-08-29 | 2015-09-23 | 萨利克斯药品有限公司 | 用于治疗便秘和相关胃肠道疾病和疾病状态的泻药组合物和方法 |
| MX366159B (es) | 2012-11-30 | 2019-07-01 | Acura Pharmaceuticals Inc | Liberacion autorregulada de ingrediente farmaceutico activo. |
| FR3002735B1 (fr) * | 2013-03-04 | 2015-07-03 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
| FR3002736B1 (fr) * | 2013-03-04 | 2015-06-26 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
| US10420729B2 (en) | 2013-03-15 | 2019-09-24 | R.P. Scherer Technologies, Llc | Abuse resistant capsule |
| ES2681952T3 (es) | 2013-03-15 | 2018-09-17 | SpecGx LLC | Forma farmacéutica sólida disuasoria del abuso de liberación inmediata con puntaje funcional |
| AU2015237721B2 (en) | 2014-03-26 | 2018-04-26 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
| PT3164117T (pt) | 2014-07-03 | 2023-12-12 | SpecGx LLC | Formulações de libertação imediata de dissuasão de abuso compreendendo polissacáridos não celulósicos |
| US9155704B1 (en) * | 2014-07-13 | 2015-10-13 | Jugal K. Taneja | More palatable, bioequivalent pharmaceutical composition of carprofen |
| WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| WO2020068510A1 (en) | 2018-09-25 | 2020-04-02 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
| US12514862B2 (en) | 2020-02-05 | 2026-01-06 | Neurocrine UK Limited | Testosterone containing pharmaceutical composition |
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| JPS60105612A (ja) * | 1983-10-03 | 1985-06-11 | バイオ・ダ−・リミテッド | 薬学的活性物質の経口摂取用投与物，その摂取方法，およびその製造方法 |
| US4581381A (en) * | 1983-11-14 | 1986-04-08 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| JPH07242568A (ja) * | 1994-03-04 | 1995-09-19 | Eisai Co Ltd | 苦味隠蔽製剤 |
| JPH092949A (ja) * | 1995-06-13 | 1997-01-07 | American Home Prod Corp | Ｓ（＋）−イブプロフェンの経口製剤 |
| WO1997034496A2 (en) * | 1996-03-15 | 1997-09-25 | Angelos Kontos | Process for addition of sterile gaseous nitrogen and pharmaceutically active substances to solid yoghurt |
| WO1998035672A1 (en) * | 1997-02-14 | 1998-08-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulations comprising amoxocyllin and clavulanate |
| WO1999047122A1 (en) * | 1998-03-16 | 1999-09-23 | Smtm Group, Llc | Chewable calcium supplement and method for making it |
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| US2238973A (en) | 1940-07-26 | 1941-04-22 | American Cyanamid Co | Sulphonamide compound in oil |
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| DE1482489A1 (de) | 1965-01-13 | 1970-03-12 | Boehringer Mannheim Gmbh | Vollautomatisches Dragierverfahren |
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| US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4749575A (en) | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
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| US5032404A (en) | 1989-02-23 | 1991-07-16 | Board Of Regents, The University Of Texas System | Lipsome-incorporation of polyenes |
| US5229131A (en) * | 1990-02-05 | 1993-07-20 | University Of Michigan | Pulsatile drug delivery system |
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| US6340471B1 (en) * | 1999-12-30 | 2002-01-22 | Alvin Kershman | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
-
2000
- 2000-09-06 US US09/656,297 patent/US6541025B1/en not_active Expired - Lifetime
- 2000-12-20 AU AU24463/01A patent/AU780136B2/en not_active Ceased
- 2000-12-20 JP JP2001549640A patent/JP2003523959A/ja active Pending
- 2000-12-20 EP EP00988234A patent/EP1246615B1/en not_active Expired - Lifetime
- 2000-12-20 WO PCT/US2000/034776 patent/WO2001049272A2/en not_active Ceased
- 2000-12-20 CA CA2392621A patent/CA2392621C/en not_active Expired - Lifetime
-
2006
- 2006-07-21 US US11/490,594 patent/US20070026066A1/en not_active Abandoned
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS60105612A (ja) * | 1983-10-03 | 1985-06-11 | バイオ・ダ−・リミテッド | 薬学的活性物質の経口摂取用投与物，その摂取方法，およびその製造方法 |
| US4581381A (en) * | 1983-11-14 | 1986-04-08 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| JPH07242568A (ja) * | 1994-03-04 | 1995-09-19 | Eisai Co Ltd | 苦味隠蔽製剤 |
| JPH092949A (ja) * | 1995-06-13 | 1997-01-07 | American Home Prod Corp | Ｓ（＋）−イブプロフェンの経口製剤 |
| WO1997034496A2 (en) * | 1996-03-15 | 1997-09-25 | Angelos Kontos | Process for addition of sterile gaseous nitrogen and pharmaceutically active substances to solid yoghurt |
| WO1998035672A1 (en) * | 1997-02-14 | 1998-08-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulations comprising amoxocyllin and clavulanate |
| WO1999047122A1 (en) * | 1998-03-16 | 1999-09-23 | Smtm Group, Llc | Chewable calcium supplement and method for making it |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2446301A (en) | 2001-07-16 |
| CA2392621C (en) | 2010-11-02 |
| EP1246615A2 (en) | 2002-10-09 |
| CA2392621A1 (en) | 2001-07-12 |
| WO2001049272A3 (en) | 2002-01-31 |
| WO2001049272A2 (en) | 2001-07-12 |
| US20070026066A1 (en) | 2007-02-01 |
| AU780136B2 (en) | 2005-03-03 |
| EP1246615B1 (en) | 2010-04-21 |
| US6541025B1 (en) | 2003-04-01 |
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