JP2003523959A5 - - Google Patents
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- Publication number
- JP2003523959A5 JP2003523959A5 JP2001549640A JP2001549640A JP2003523959A5 JP 2003523959 A5 JP2003523959 A5 JP 2003523959A5 JP 2001549640 A JP2001549640 A JP 2001549640A JP 2001549640 A JP2001549640 A JP 2001549640A JP 2003523959 A5 JP2003523959 A5 JP 2003523959A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- lipid
- dry particles
- delivery system
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000725 suspension Substances 0.000 description 44
- 150000002632 lipids Chemical class 0.000 description 42
- 239000002245 particle Substances 0.000 description 38
- 238000000034 method Methods 0.000 description 22
- 238000012377 drug delivery Methods 0.000 description 18
- 239000003795 chemical substances by application Substances 0.000 description 17
- 239000007788 liquid Substances 0.000 description 15
- 239000004094 surface-active agent Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 238000000465 moulding Methods 0.000 description 8
- 229940126701 oral medication Drugs 0.000 description 8
- 230000009974 thixotropic effect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- 239000007909 solid dosage form Substances 0.000 description 7
- 239000000945 filler Substances 0.000 description 6
- 229940079832 sodium starch glycolate Drugs 0.000 description 5
- 229920003109 sodium starch glycolate Polymers 0.000 description 5
- 239000008109 sodium starch glycolate Substances 0.000 description 5
- 230000009172 bursting Effects 0.000 description 4
- 235000014121 butter Nutrition 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002327 cardiovascular agent Substances 0.000 description 2
- 229940125692 cardiovascular agent Drugs 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000004083 gastrointestinal agent Substances 0.000 description 2
- 229940127227 gastrointestinal drug Drugs 0.000 description 2
- 239000003629 gastrointestinal hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000008141 laxative Substances 0.000 description 2
- 229940125722 laxative agent Drugs 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 239000012169 petroleum derived wax Substances 0.000 description 2
- 235000019381 petroleum wax Nutrition 0.000 description 2
- 235000019871 vegetable fat Nutrition 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 1
- 238000007580 dry-mixing Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/476,483 | 1999-12-30 | ||
| US09/476,483 US6340471B1 (en) | 1999-12-30 | 1999-12-30 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US09/656,297 | 2000-09-06 | ||
| US09/656,297 US6541025B1 (en) | 1999-12-30 | 2000-09-06 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| PCT/US2000/034776 WO2001049272A2 (en) | 1999-12-30 | 2000-12-20 | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523959A JP2003523959A (ja) | 2003-08-12 |
| JP2003523959A5 true JP2003523959A5 (https=) | 2008-02-14 |
Family
ID=27045193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549640A Pending JP2003523959A (ja) | 1999-12-30 | 2000-12-20 | カプセル化及び非カプセル化薬剤の為の固体送達システムを調製する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6541025B1 (https=) |
| EP (1) | EP1246615B1 (https=) |
| JP (1) | JP2003523959A (https=) |
| AU (1) | AU780136B2 (https=) |
| CA (1) | CA2392621C (https=) |
| WO (1) | WO2001049272A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US7067148B2 (en) | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| SE0200154D0 (sv) * | 2002-01-21 | 2002-01-21 | Galenica Ab | New process |
| US20030190343A1 (en) * | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
| CO5400144A1 (es) | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
| US20040096498A1 (en) * | 2002-04-29 | 2004-05-20 | Alvin Kershman | Oral pharmaceutical delivery system with improved sustained release |
| US20030235613A1 (en) * | 2002-06-19 | 2003-12-25 | Cts Chemical Industries Ltd. | Popping oral administration form |
| EP1759692A3 (en) * | 2003-03-10 | 2007-09-12 | Novartis AG | Taste-masked solid veterinary compositions |
| US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| US20070122488A1 (en) * | 2004-02-25 | 2007-05-31 | Erich Windhab | Multi-functional microcapsules and method and device for manufacturing same |
| US8075910B2 (en) * | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| WO2006036624A2 (en) * | 2004-09-24 | 2006-04-06 | The Hartz Mountain Corporation | Lipid stabilized formulations |
| US7956235B2 (en) * | 2004-12-29 | 2011-06-07 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a temperature change member |
| US20060142716A1 (en) * | 2004-12-29 | 2006-06-29 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a non-abrasive temperature change member |
| US8129582B2 (en) * | 2004-12-29 | 2012-03-06 | Kimberly-Clark Worldwide, Inc. | Absorbent article featuring a temperature change member |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US8486452B2 (en) * | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| US8110226B2 (en) * | 2007-07-20 | 2012-02-07 | Mylan Pharmaceuticals Inc. | Drug formulations having inert sealed cores |
| GB0807605D0 (en) | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| AU2010300641B2 (en) * | 2009-09-30 | 2016-03-17 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
| US9993422B2 (en) | 2012-04-18 | 2018-06-12 | SpecGx LLC | Immediate release, abuse deterrent pharmaceutical compositions |
| EP2872121B1 (en) | 2012-07-12 | 2018-09-05 | SpecGx LLC | Extended release, abuse deterrent pharmaceutical compositions |
| MX2015002210A (es) * | 2012-08-29 | 2015-05-08 | Salix Pharmaceuticals Inc | Composiciones laxantes y metodos para tratar estreñimiento y enfermedades y condiciones gastrointestinales relacionadas. |
| MX366159B (es) | 2012-11-30 | 2019-07-01 | Acura Pharmaceuticals Inc | Liberacion autorregulada de ingrediente farmaceutico activo. |
| FR3002735B1 (fr) | 2013-03-04 | 2015-07-03 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
| FR3002736B1 (fr) | 2013-03-04 | 2015-06-26 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
| CA2901802C (en) | 2013-03-15 | 2021-03-02 | Mallinckrodt Llc | Abuse deterrent solid dosage form for immediate release with functional score |
| US10420729B2 (en) | 2013-03-15 | 2019-09-24 | R.P. Scherer Technologies, Llc | Abuse resistant capsule |
| WO2015145461A1 (en) | 2014-03-26 | 2015-10-01 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release biphasic matrix solid dosage form |
| WO2016004170A1 (en) | 2014-07-03 | 2016-01-07 | Mallinckrodt Llc | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
| US9155704B1 (en) * | 2014-07-13 | 2015-10-13 | Jugal K. Taneja | More palatable, bioequivalent pharmaceutical composition of carprofen |
| US11103581B2 (en) | 2015-08-31 | 2021-08-31 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| EP3856160A4 (en) | 2018-09-25 | 2022-07-06 | SpecGx LLC | ABUSE-PROOF IMMEDIATE RELEASE CAPSULE DOSAGE FORMS |
| AU2021216630A1 (en) | 2020-02-05 | 2022-09-22 | Neurocrine UK Limited | Testosterone containing pharmaceutical composition |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2238973A (en) | 1940-07-26 | 1941-04-22 | American Cyanamid Co | Sulphonamide compound in oil |
| US3238103A (en) | 1961-04-26 | 1966-03-01 | Clarence A Vogenthaler | Therapeutic composition and method of making it |
| US3253988A (en) | 1962-11-20 | 1966-05-31 | Robert I Pearlman | Antacid composition and method of using same |
| DE1482489A1 (de) | 1965-01-13 | 1970-03-12 | Boehringer Mannheim Gmbh | Vollautomatisches Dragierverfahren |
| US3843778A (en) | 1970-04-28 | 1974-10-22 | Rorer Inc William H | Antacids |
| US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| SE8404808L (sv) * | 1983-10-03 | 1985-04-04 | Avner Rotman | Mikrokapslat lekemedel i sot matris |
| US4749575A (en) | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
| US4581381A (en) | 1983-11-14 | 1986-04-08 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| US4981690A (en) | 1987-10-27 | 1991-01-01 | Board Of Regents, The University Of Texas System | Liposome-incorporated mepartricin |
| US5032404A (en) | 1989-02-23 | 1991-07-16 | Board Of Regents, The University Of Texas System | Lipsome-incorporation of polyenes |
| US5229131A (en) * | 1990-02-05 | 1993-07-20 | University Of Michigan | Pulsatile drug delivery system |
| JPH06501354A (ja) * | 1990-10-09 | 1994-02-10 | スタージェ・アコムパニー・ベスローテン・フェンノートシャップ | 冷却装置を備えたダイナミックラウドスピーカ |
| US5175002A (en) | 1991-10-02 | 1992-12-29 | Du Pont Merck Pharmaceutical Company | Amantadine hydrochloride syspension with enhanced dissolution characteristics for use in soft gelatin capsules |
| EP0664701B1 (en) * | 1992-10-16 | 1997-09-10 | Glaxo Group Limited | Taste-masking compositions of ranitidine |
| GR1001437B (el) | 1992-11-05 | 1993-12-30 | Aggelos Kontos | Ζαχαροπλαστικό σύστημα χορηγήσεως φαρμακολογικώς δραστικών ουσιών. |
| US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| JPH07242568A (ja) * | 1994-03-04 | 1995-09-19 | Eisai Co Ltd | 苦味隠蔽製剤 |
| US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
| TW442287B (en) * | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
| GR1002668B (el) | 1996-03-15 | 1997-04-14 | N | Μεθοδος προσθηκης στειρου αεριου αζωτου και φαρμακολογικως δραστικων ουσιων εις στερεο γιαουρτι. |
| CA2280857A1 (en) * | 1997-02-14 | 1998-08-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Pharmaceutical formulations comprising amoxocyllin and clavulanate |
| AU9003798A (en) * | 1997-09-16 | 1999-04-05 | Snk Corporation | Apparatus for preparing reproduced image, method of preparation and reproduced image |
| US6241997B1 (en) | 1998-03-16 | 2001-06-05 | Smtm Group. Llc | Chewable calcium supplement and method |
| US6221857B1 (en) * | 1998-06-10 | 2001-04-24 | North Carolina State University | Altering sex ratio of offspring in mammals |
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US6340471B1 (en) * | 1999-12-30 | 2002-01-22 | Alvin Kershman | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
-
2000
- 2000-09-06 US US09/656,297 patent/US6541025B1/en not_active Expired - Lifetime
- 2000-12-20 JP JP2001549640A patent/JP2003523959A/ja active Pending
- 2000-12-20 CA CA2392621A patent/CA2392621C/en not_active Expired - Lifetime
- 2000-12-20 EP EP00988234A patent/EP1246615B1/en not_active Expired - Lifetime
- 2000-12-20 AU AU24463/01A patent/AU780136B2/en not_active Ceased
- 2000-12-20 WO PCT/US2000/034776 patent/WO2001049272A2/en not_active Ceased
-
2006
- 2006-07-21 US US11/490,594 patent/US20070026066A1/en not_active Abandoned
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