JP2003522524A - 高次核酸型構造体 - Google Patents

高次核酸型構造体

Info

Publication number
JP2003522524A
JP2003522524A JP2001538503A JP2001538503A JP2003522524A JP 2003522524 A JP2003522524 A JP 2003522524A JP 2001538503 A JP2001538503 A JP 2001538503A JP 2001538503 A JP2001538503 A JP 2001538503A JP 2003522524 A JP2003522524 A JP 2003522524A
Authority
JP
Japan
Prior art keywords
nucleic acid
polynucleic acid
molecules
molecule
structure according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001538503A
Other languages
English (en)
Japanese (ja)
Inventor
フランク、 ジェー． カー、
グラハム カーター、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9926810.4A external-priority patent/GB9926810D0/en
Priority claimed from GB0011126A external-priority patent/GB0011126D0/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2003522524A publication Critical patent/JP2003522524A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/52—Physical structure branched

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2001538503A 1999-11-13 2000-11-13 高次核酸型構造体 Pending JP2003522524A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9926810.4A GB9926810D0 (en) 1999-11-13 1999-11-13 High order nucleic acid-based structures
GB9926810.4 1999-11-13
GB0011126.0 2000-05-10
GB0011126A GB0011126D0 (en) 2000-05-10 2000-05-10 High order nucleic acid-based structures
PCT/EP2000/011197 WO2001036624A1 (en) 1999-11-13 2000-11-13 High order nucleic acid based structures

Publications (1)

Publication Number Publication Date
JP2003522524A true JP2003522524A (ja) 2003-07-29

Family

ID=26244234

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001538503A Pending JP2003522524A (ja) 1999-11-13 2000-11-13 高次核酸型構造体

Country Status (16)

Country Link
EP (1) EP1228201A1 (pt)
JP (1) JP2003522524A (pt)
KR (1) KR20020059727A (pt)
CN (1) CN1390253A (pt)
AU (1) AU782880B2 (pt)
BR (1) BR0015484A (pt)
CA (1) CA2391084A1 (pt)
CZ (1) CZ20021472A3 (pt)
HK (1) HK1052529A1 (pt)
HU (1) HUP0203914A2 (pt)
MX (1) MXPA02004727A (pt)
NO (1) NO20022231D0 (pt)
PL (1) PL358811A1 (pt)
RU (1) RU2002113755A (pt)
SK (1) SK6042002A3 (pt)
WO (1) WO2001036624A1 (pt)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017505104A (ja) * 2013-11-08 2017-02-16 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド インビボにおける薬剤送達のための核酸ナノ構造体
US11254972B2 (en) 2016-08-02 2022-02-22 President And Fellows Of Harvard College Crisscross cooperative self-assembly
US11414694B2 (en) 2016-03-11 2022-08-16 Children's Medical Center Corporation Nucleic acid nanoswitch catenanes

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523721A (ja) 1998-12-31 2003-08-12 カイロン コーポレイション 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
CA2452015C (en) 2001-07-05 2012-07-03 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
EP2739638B1 (en) * 2011-08-05 2017-10-04 President and Fellows of Harvard College Compositions and methods relating to nucleic acid nano-and micro-technology
KR20160073936A (ko) 2012-07-24 2016-06-27 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 나노구조의 자기-조립
WO2014074597A1 (en) 2012-11-06 2014-05-15 President And Fellows Of Harvard College Compositions and methods relating to complex nucleic acid nanostructures
CN106488883A (zh) 2014-05-22 2017-03-08 哈佛学院院长及董事 可扩展的基于核酸的纳米制造
CN110711254B (zh) * 2018-07-12 2022-07-26 百药智达（北京）纳米生物技术有限公司 核酸纳米颗粒及包含其的药物组合物
EP3821911A4 (en) * 2018-07-12 2022-03-09 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. NUCLEIC ACID NANOPARTICLES, PHARMACEUTICAL COMPOSITION COMPRISING THEM, MEDICATION COMPRISING DOXORUBICIN, AND METHOD FOR PREPARING THEM
CN110960536B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含阿司匹林的药物、其制备方法、药物组合物及应用
CN110960542B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含吡柔比星的药物、其制备方法、药物组合物及其应用
CN110960534B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含五氟尿嘧啶的药物、其制备方法、药物组合物及其应用
CN110960530B (zh) * 2018-09-30 2022-07-22 百药智达（北京）纳米生物技术有限公司 含他克林的药物、其制备方法、药物组合物及其应用
CN110960690B (zh) * 2018-09-30 2022-07-22 百药智达（北京）纳米生物技术有限公司 含表柔比星的药物、其制备方法、药物组合物及其应用
CN111053765B (zh) * 2018-10-16 2022-07-26 百药智达（北京）纳米生物技术有限公司 含紫杉醇的药物、其制备方法、药物组合物及应用
CN111068065B (zh) * 2018-10-22 2022-07-26 百药智达（北京）纳米生物技术有限公司 含奥沙利铂的药物、其制备方法、药物组合物及其应用
CN111084887B (zh) * 2018-10-23 2022-07-22 百药智达（北京）纳米生物技术有限公司 含黄酮的药物、其制备方法、药物组合物及应用
CN111096965B (zh) * 2018-10-29 2022-07-26 百药智达（北京）纳米生物技术有限公司 含双氢青蒿素的药物、其制备方法、药物组合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151631A1 (en) * 1983-08-03 1985-08-21 The Research Foundation Of State University Of New York Nucleic acid branched junctions with precisely defined migrational mobility
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017505104A (ja) * 2013-11-08 2017-02-16 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド インビボにおける薬剤送達のための核酸ナノ構造体
US11414694B2 (en) 2016-03-11 2022-08-16 Children's Medical Center Corporation Nucleic acid nanoswitch catenanes
US11254972B2 (en) 2016-08-02 2022-02-22 President And Fellows Of Harvard College Crisscross cooperative self-assembly

Also Published As

Publication number Publication date
CA2391084A1 (en) 2001-05-25
SK6042002A3 (en) 2002-12-03
HUP0203914A2 (en) 2003-03-28
HK1052529A1 (zh) 2003-09-19
WO2001036624A1 (en) 2001-05-25
MXPA02004727A (es) 2002-08-30
NO20022231L (no) 2002-05-10
BR0015484A (pt) 2002-07-02
EP1228201A1 (en) 2002-08-07
CN1390253A (zh) 2003-01-08
KR20020059727A (ko) 2002-07-13
PL358811A1 (en) 2004-08-23
NO20022231D0 (no) 2002-05-10
AU782880B2 (en) 2005-09-08
RU2002113755A (ru) 2004-01-10
AU2000101A (en) 2001-05-30
CZ20021472A3 (cs) 2002-07-17

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