JP2003521438A - 多環式α−アミノ−ε−カプロラクタムおよび関連化合物 - Google Patents
多環式α−アミノ−ε−カプロラクタムおよび関連化合物Info
- Publication number
- JP2003521438A JP2003521438A JP2000525390A JP2000525390A JP2003521438A JP 2003521438 A JP2003521438 A JP 2003521438A JP 2000525390 A JP2000525390 A JP 2000525390A JP 2000525390 A JP2000525390 A JP 2000525390A JP 2003521438 A JP2003521438 A JP 2003521438A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- substituted
- dihydro
- dibenzo
- azepin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/996,422 | 1997-12-22 | ||
US08/996,422 US6635632B1 (en) | 1996-12-23 | 1997-12-22 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US10272698A | 1998-06-22 | 1998-06-22 | |
US09/102,726 | 1998-06-22 | ||
PCT/US1998/022637 WO1999032453A1 (en) | 1997-12-22 | 1998-10-29 | POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2003521438A true JP2003521438A (ja) | 2003-07-15 |
Family
ID=26799672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000525390A Withdrawn JP2003521438A (ja) | 1997-12-22 | 1998-10-29 | 多環式α−アミノ−ε−カプロラクタムおよび関連化合物 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1042298A1 (pt) |
JP (1) | JP2003521438A (pt) |
KR (1) | KR20010033408A (pt) |
AU (1) | AU1277799A (pt) |
BR (1) | BR9812773A (pt) |
CA (1) | CA2307221A1 (pt) |
HU (1) | HUP0100294A3 (pt) |
IL (1) | IL135564A0 (pt) |
WO (1) | WO1999032453A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
CN1636011A (zh) | 1998-12-24 | 2005-07-06 | 杜邦药品公司 | 作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬 |
WO2001002358A2 (en) * | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | Cyclized amide derivatives for treating or preventing neuronal damage |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
CN1399634A (zh) * | 1999-09-13 | 2003-02-26 | 布里斯托尔-迈尔斯斯奎布药品公司 | 用作Aβ蛋白生成抑制剂的羟基链烷醇氨基内酰胺和相关结构 |
AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
CA2395862A1 (en) * | 2000-02-17 | 2001-08-23 | Hong Liu | Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production |
CN1434803A (zh) | 2000-04-03 | 2003-08-06 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白质产生抑制剂的环内酰胺 |
IL151576A0 (en) | 2000-04-03 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic lactams as inhibitors of a-beta protein production |
AU2001257006A1 (en) | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
CA2379445C (en) | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
EP1298436B1 (en) * | 1992-10-26 | 2010-07-14 | Elan Pharmaceuticals, Inc. | Methods for the identification of Beta-amyloid peptide (BAP) release inhibitor compounds |
CZ184194A3 (en) * | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
EA002100B1 (ru) * | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
HRP980093A2 (en) * | 1997-02-28 | 1998-12-31 | Lilly Co Eli | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds |
-
1998
- 1998-10-29 JP JP2000525390A patent/JP2003521438A/ja not_active Withdrawn
- 1998-10-29 BR BR9812773-0A patent/BR9812773A/pt not_active IP Right Cessation
- 1998-10-29 HU HU0100294A patent/HUP0100294A3/hu unknown
- 1998-10-29 AU AU12777/99A patent/AU1277799A/en not_active Abandoned
- 1998-10-29 WO PCT/US1998/022637 patent/WO1999032453A1/en not_active Application Discontinuation
- 1998-10-29 IL IL13556498A patent/IL135564A0/xx unknown
- 1998-10-29 CA CA002307221A patent/CA2307221A1/en not_active Abandoned
- 1998-10-29 EP EP98956198A patent/EP1042298A1/en not_active Withdrawn
- 1998-10-29 KR KR1020007006883A patent/KR20010033408A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0100294A2 (hu) | 2001-09-28 |
CA2307221A1 (en) | 1999-07-01 |
EP1042298A1 (en) | 2000-10-11 |
AU1277799A (en) | 1999-07-12 |
IL135564A0 (en) | 2001-05-20 |
BR9812773A (pt) | 2000-10-10 |
KR20010033408A (ko) | 2001-04-25 |
HUP0100294A3 (en) | 2003-04-28 |
WO1999032453A1 (en) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A300 | Application deemed to be withdrawn because no request for examination was validly filed |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20060110 |