JP2003517476A5 - - Google Patents
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- Publication number
- JP2003517476A5 JP2003517476A5 JP2001543508A JP2001543508A JP2003517476A5 JP 2003517476 A5 JP2003517476 A5 JP 2003517476A5 JP 2001543508 A JP2001543508 A JP 2001543508A JP 2001543508 A JP2001543508 A JP 2001543508A JP 2003517476 A5 JP2003517476 A5 JP 2003517476A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- substituted alkyl
- pharmaceutical composition
- nhch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45092099A | 1999-11-29 | 1999-11-29 | |
| US09/450,920 | 1999-11-29 | ||
| PCT/US2000/042313 WO2001042207A2 (en) | 1999-11-29 | 2000-11-29 | Novel methods for the treatment and prevention of ileus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012092605A Division JP5460771B2 (ja) | 1999-11-29 | 2012-04-16 | イレウスの治療及び予防のための新規な方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517476A JP2003517476A (ja) | 2003-05-27 |
| JP2003517476A5 true JP2003517476A5 (https=) | 2008-01-31 |
| JP5079961B2 JP5079961B2 (ja) | 2012-11-21 |
Family
ID=23790061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543508A Expired - Fee Related JP5079961B2 (ja) | 1999-11-29 | 2000-11-29 | イレウスの治療及び予防のための新規な方法 |
| JP2012092605A Expired - Fee Related JP5460771B2 (ja) | 1999-11-29 | 2012-04-16 | イレウスの治療及び予防のための新規な方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012092605A Expired - Fee Related JP5460771B2 (ja) | 1999-11-29 | 2012-04-16 | イレウスの治療及び予防のための新規な方法 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1244448B1 (https=) |
| JP (2) | JP5079961B2 (https=) |
| AT (1) | ATE432076T1 (https=) |
| AU (2) | AU780738B2 (https=) |
| CA (1) | CA2393141C (https=) |
| CY (1) | CY1109264T1 (https=) |
| DE (1) | DE60042282D1 (https=) |
| DK (1) | DK1244448T3 (https=) |
| ES (1) | ES2329004T3 (https=) |
| IL (2) | IL149650A0 (https=) |
| MX (1) | MXPA02005336A (https=) |
| NZ (1) | NZ518684A (https=) |
| PT (1) | PT1244448E (https=) |
| WO (1) | WO2001042207A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| US6992090B2 (en) * | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| JP5176188B2 (ja) | 2006-04-21 | 2013-04-03 | ディーエスエム アイピー アセッツ ビー．ブイ． | オピオイド受容体拮抗薬の使用 |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| MX2009010550A (es) | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| SI2565195T1 (sl) | 2007-03-29 | 2015-09-30 | Wyeth Llc | Periferalni opioidni receptorji in antagonisti in njih uporaba |
| CL2008000905A1 (es) | 2007-03-29 | 2008-08-22 | Progenics Pharm Inc | Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena. |
| EP2240489A1 (en) | 2008-02-06 | 2010-10-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| EP2278966B1 (en) | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| RU2455943C1 (ru) * | 2011-02-01 | 2012-07-20 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Способ лечения обтурационной формы острой спаечной тонкокишечной непроходимости |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1420015B1 (de) * | 1959-10-16 | 1971-08-26 | Boehringer Sohn Ingelheim | 2'-Hydroxy-5,9-dimethyl-6,7-benzomorphane |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| FR2514644A1 (fr) * | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| EP0103636B1 (en) * | 1982-03-16 | 1990-09-12 | Rockefeller University | Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility |
| US4730048A (en) * | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4806556A (en) * | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
-
2000
- 2000-11-29 NZ NZ518684A patent/NZ518684A/xx unknown
- 2000-11-29 WO PCT/US2000/042313 patent/WO2001042207A2/en not_active Ceased
- 2000-11-29 CA CA2393141A patent/CA2393141C/en not_active Expired - Fee Related
- 2000-11-29 ES ES00992255T patent/ES2329004T3/es not_active Expired - Lifetime
- 2000-11-29 JP JP2001543508A patent/JP5079961B2/ja not_active Expired - Fee Related
- 2000-11-29 IL IL14965000A patent/IL149650A0/xx active IP Right Grant
- 2000-11-29 MX MXPA02005336A patent/MXPA02005336A/es active IP Right Grant
- 2000-11-29 DE DE60042282T patent/DE60042282D1/de not_active Expired - Lifetime
- 2000-11-29 PT PT00992255T patent/PT1244448E/pt unknown
- 2000-11-29 AU AU39705/01A patent/AU780738B2/en not_active Ceased
- 2000-11-29 AT AT00992255T patent/ATE432076T1/de not_active IP Right Cessation
- 2000-11-29 DK DK00992255T patent/DK1244448T3/da active
- 2000-11-29 EP EP00992255A patent/EP1244448B1/en not_active Expired - Lifetime
-
2002
- 2002-05-14 IL IL149650A patent/IL149650A/en not_active IP Right Cessation
-
2005
- 2005-07-13 AU AU2005203041A patent/AU2005203041B2/en not_active Ceased
-
2009
- 2009-08-05 CY CY20091100828T patent/CY1109264T1/el unknown
-
2012
- 2012-04-16 JP JP2012092605A patent/JP5460771B2/ja not_active Expired - Fee Related
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