JP2003516144A5 - - Google Patents
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- Publication number
- JP2003516144A5 JP2003516144A5 JP2001544313A JP2001544313A JP2003516144A5 JP 2003516144 A5 JP2003516144 A5 JP 2003516144A5 JP 2001544313 A JP2001544313 A JP 2001544313A JP 2001544313 A JP2001544313 A JP 2001544313A JP 2003516144 A5 JP2003516144 A5 JP 2003516144A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cyclin
- hdac8
- homology
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101001032118 Homo sapiens Histone deacetylase 8 Proteins 0.000 description 7
- 102100038715 Histone deacetylase 8 Human genes 0.000 description 6
- 102100021455 Histone deacetylase 3 Human genes 0.000 description 4
- 101000899282 Homo sapiens Histone deacetylase 3 Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 108091060211 Expressed sequence tag Proteins 0.000 description 3
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 102000002427 Cyclin B Human genes 0.000 description 2
- 102100039996 Histone deacetylase 1 Human genes 0.000 description 2
- 102100039999 Histone deacetylase 2 Human genes 0.000 description 2
- 101001035024 Homo sapiens Histone deacetylase 1 Proteins 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108010068192 Cyclin A Proteins 0.000 description 1
- 108010060385 Cyclin B1 Proteins 0.000 description 1
- 102100025191 Cyclin-A2 Human genes 0.000 description 1
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 1
- 102000003964 Histone deacetylase Human genes 0.000 description 1
- 108090000353 Histone deacetylase Proteins 0.000 description 1
- 101100059444 Mus musculus Ccnb1 gene Proteins 0.000 description 1
- 101100005613 Mus musculus Ccnb2 gene Proteins 0.000 description 1
- 101000934300 Mus musculus Cyclin-A2 Proteins 0.000 description 1
- 101000601947 Mus musculus Proliferating cell nuclear antigen Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 101001113506 Rattus norvegicus Proliferating cell nuclear antigen Proteins 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006195 histone acetylation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16972399P | 1999-12-08 | 1999-12-08 | |
| US60/169,723 | 1999-12-08 | ||
| PCT/US2000/033622 WO2001042437A2 (en) | 1999-12-08 | 2000-12-08 | Histone deacetylase-8 proteins, nucleic acids, and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011123587A Division JP2011182800A (ja) | 1999-12-08 | 2011-06-01 | ヒストン脱アセチル化酵素−８のタンパク質、核酸およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003516144A JP2003516144A (ja) | 2003-05-13 |
| JP2003516144A5 true JP2003516144A5 (enExample) | 2008-02-21 |
Family
ID=22616924
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544313A Pending JP2003516144A (ja) | 1999-12-08 | 2000-12-08 | ヒストン脱アセチル化酵素−８のタンパク質、核酸およびその使用方法 |
| JP2011123587A Pending JP2011182800A (ja) | 1999-12-08 | 2011-06-01 | ヒストン脱アセチル化酵素−８のタンパク質、核酸およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011123587A Pending JP2011182800A (ja) | 1999-12-08 | 2011-06-01 | ヒストン脱アセチル化酵素−８のタンパク質、核酸およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1246905B1 (enExample) |
| JP (2) | JP2003516144A (enExample) |
| AT (1) | ATE320484T1 (enExample) |
| AU (1) | AU1959001A (enExample) |
| CA (1) | CA2393725A1 (enExample) |
| DE (1) | DE60026733T2 (enExample) |
| ES (1) | ES2260080T3 (enExample) |
| WO (1) | WO2001042437A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001042437A2 (en) * | 1999-12-08 | 2001-06-14 | Axys Pharmaceuticals, Inc. | Histone deacetylase-8 proteins, nucleic acids, and methods of use |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| EP1409661A4 (en) | 2001-06-14 | 2006-02-01 | Sloan Kettering Inst Cancer | HDAC9 POLYPEPTIDES, POLYNUCLEOTIDES AND USES THEREOF |
| WO2002102316A2 (en) * | 2001-06-19 | 2002-12-27 | The Regents Of The University Of California | Histone deacetylase and methods of use thereof |
| US6706686B2 (en) | 2001-09-27 | 2004-03-16 | The Regents Of The University Of Colorado | Inhibition of histone deacetylase as a treatment for cardiac hypertrophy |
| GB0123664D0 (en) * | 2001-10-02 | 2001-11-21 | Inst Of Cancer Res The | Histone deacetylase 9 |
| WO2003032921A2 (en) | 2001-10-16 | 2003-04-24 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| US20060051815A1 (en) | 2004-06-25 | 2006-03-09 | The J. David Gladstone Institutes | Methods of treating smooth muscle cell disorders |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| WO2006122319A2 (en) | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| ZA200800901B (en) | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
| GB0620823D0 (en) | 2006-10-19 | 2006-11-29 | Univ London | Histone deacetylase inhibitors |
| CN105979941A (zh) * | 2013-08-20 | 2016-09-28 | 希望之城 | 用于治疗癌症的hdac8抑制剂 |
| US10184933B2 (en) | 2013-10-01 | 2019-01-22 | The J. David Gladstone Industries | Compositions, systems and methods for gene expression noise drug screening and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000010583A1 (en) * | 1998-08-21 | 2000-03-02 | Smithkline Beecham Corporation | Human histone deacetylase gene hd4 |
| WO2001042437A2 (en) * | 1999-12-08 | 2001-06-14 | Axys Pharmaceuticals, Inc. | Histone deacetylase-8 proteins, nucleic acids, and methods of use |
-
2000
- 2000-12-08 WO PCT/US2000/033622 patent/WO2001042437A2/en not_active Ceased
- 2000-12-08 CA CA002393725A patent/CA2393725A1/en not_active Abandoned
- 2000-12-08 AT AT00982576T patent/ATE320484T1/de not_active IP Right Cessation
- 2000-12-08 ES ES00982576T patent/ES2260080T3/es not_active Expired - Lifetime
- 2000-12-08 AU AU19590/01A patent/AU1959001A/en not_active Abandoned
- 2000-12-08 JP JP2001544313A patent/JP2003516144A/ja active Pending
- 2000-12-08 EP EP00982576A patent/EP1246905B1/en not_active Expired - Lifetime
- 2000-12-08 DE DE60026733T patent/DE60026733T2/de not_active Expired - Lifetime
-
2011
- 2011-06-01 JP JP2011123587A patent/JP2011182800A/ja active Pending
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