JP2003515569A - ワクチンアジュバントとして有用なインターロイキン−１ムテイン - Google Patents
ワクチンアジュバントとして有用なインターロイキン−１ムテインInfo
- Publication number
- JP2003515569A JP2003515569A JP2001541535A JP2001541535A JP2003515569A JP 2003515569 A JP2003515569 A JP 2003515569A JP 2001541535 A JP2001541535 A JP 2001541535A JP 2001541535 A JP2001541535 A JP 2001541535A JP 2003515569 A JP2003515569 A JP 2003515569A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antigen
- adjuvant
- antigens
- mutein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000008732 thymoma Diseases 0.000 description 1
- 230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000007888 toxin activity Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
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- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16892899P | 1999-12-03 | 1999-12-03 | |
| US60/168,928 | 1999-12-03 | ||
| PCT/US2000/032813 WO2001039803A2 (en) | 1999-12-03 | 2000-12-04 | Interleukin-1 muteins useful as vaccine adjuvants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003515569A true JP2003515569A (ja) | 2003-05-07 |
| JP2003515569A5 JP2003515569A5 (enExample) | 2008-01-31 |
Family
ID=22613541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541535A Pending JP2003515569A (ja) | 1999-12-03 | 2000-12-04 | ワクチンアジュバントとして有用なインターロイキン−１ムテイン |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6656462B2 (enExample) |
| EP (1) | EP1196193B1 (enExample) |
| JP (1) | JP2003515569A (enExample) |
| AT (1) | ATE413191T1 (enExample) |
| AU (1) | AU1813701A (enExample) |
| DE (1) | DE60040740D1 (enExample) |
| WO (1) | WO2001039803A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6270758B1 (en) * | 1998-10-08 | 2001-08-07 | Duke University | Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects |
| EP1931383A1 (en) | 2005-09-28 | 2008-06-18 | Cytos Biotechnology AG | Interleukin-1 conjugates and uses thereof |
| WO2008037504A1 (en) * | 2006-09-28 | 2008-04-03 | Cytos Biotechnology Ag | Interleukin-1 muteins linked to virus-like particles to treat il-1 associated diseases |
| EP2368570A3 (en) | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| US9138470B2 (en) * | 2007-11-02 | 2015-09-22 | The Johns Hopkins University | Multi-component L2 vaccine for prevention of human papilloma virus infection |
| WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
| ES2784957T3 (es) | 2009-04-03 | 2020-10-02 | Univ Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SPA) |
| US8389474B1 (en) * | 2009-07-14 | 2013-03-05 | Alan Anson Wanderer | Rationale for IL-1 β targeted therapy to improve harvested organ viability, allograft tolerance, replant success and for conditions characterized by reduced or absent arterial perfusion |
| WO2011100508A2 (en) | 2010-02-12 | 2011-08-18 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| BR112013000097B1 (pt) | 2010-07-02 | 2022-02-01 | The University Of Chicago | Polipeptídeo imunogênico isolado, composição imunogênica e seu uso |
| EP2614074A1 (en) | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| WO2013162746A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
| WO2014085767A1 (en) * | 2012-11-29 | 2014-06-05 | University Of Rochester | Compositions and methods for treating immune conditions, including type1 diabetes |
| CN104740615A (zh) * | 2013-12-31 | 2015-07-01 | 上海索菲里奥生物医药科技发展有限公司 | IL-1β在制备用于治疗由金黄色葡萄球菌易感所引起的炎症的药物中的用途 |
| TWI601742B (zh) * | 2016-03-23 | 2017-10-11 | 國立清華大學 | 使宿主提早產生抗體及延長抗體保護時間的重組雞介白素１β蛋白質及其應用 |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| WO2019183500A1 (en) | 2018-03-23 | 2019-09-26 | Hung Chiung Yu | Coccidioides antigens and methods of their use |
| US20230293652A1 (en) * | 2020-07-07 | 2023-09-21 | Orionis Biosciences, Inc. | Immunostimulatory adjuvants |
| US20250177514A1 (en) | 2022-01-28 | 2025-06-05 | Pfizer Inc. | Coronavirus antigen variants |
| WO2025027492A1 (en) | 2023-07-31 | 2025-02-06 | Pfizer Inc. | Coronavirus antigen variants |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63152398A (ja) * | 1986-03-14 | 1988-06-24 | Otsuka Pharmaceut Co Ltd | インターロイキン−１β誘導体及び医薬 |
| JPH0824595B2 (ja) * | 1989-02-27 | 1996-03-13 | ニューイングランド メディカルセンター ホスピタルズ インコーポレイテッド | Ｉｌ―１生物活性の抑制剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342614A (en) * | 1984-12-21 | 1994-08-30 | Otsuka Pharmaceutical Co., Ltd. | Method of treating arthritus or inflammation with IL-1β or derivatives thereof |
| US5503841A (en) | 1985-09-20 | 1996-04-02 | Cetus Oncology Corporation | Human IL-2 as a vaccine adjuvant |
| IT1217314B (it) | 1987-02-20 | 1990-03-22 | Sclavo Spa | Nonapeptide sintetico ad attivita'adiuvante capace di potenziare in vivo la risposta anticorporale |
| JP3485184B2 (ja) | 1989-07-14 | 2004-01-13 | アメリカン サイアナミド カンパニー | インターロイキン含有安定ワクチン組成物 |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
-
2000
- 2000-12-04 AU AU18137/01A patent/AU1813701A/en not_active Abandoned
- 2000-12-04 JP JP2001541535A patent/JP2003515569A/ja active Pending
- 2000-12-04 EP EP00980942A patent/EP1196193B1/en not_active Expired - Lifetime
- 2000-12-04 DE DE60040740T patent/DE60040740D1/de not_active Expired - Fee Related
- 2000-12-04 US US09/729,509 patent/US6656462B2/en not_active Expired - Fee Related
- 2000-12-04 AT AT00980942T patent/ATE413191T1/de not_active IP Right Cessation
- 2000-12-04 WO PCT/US2000/032813 patent/WO2001039803A2/en not_active Ceased
-
2003
- 2003-10-14 US US10/684,774 patent/US20040253208A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63152398A (ja) * | 1986-03-14 | 1988-06-24 | Otsuka Pharmaceut Co Ltd | インターロイキン−１β誘導体及び医薬 |
| JPH0824595B2 (ja) * | 1989-02-27 | 1996-03-13 | ニューイングランド メディカルセンター ホスピタルズ インコーポレイテッド | Ｉｌ―１生物活性の抑制剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1813701A (en) | 2001-06-12 |
| WO2001039803A3 (en) | 2002-02-21 |
| US20040253208A1 (en) | 2004-12-16 |
| US20010036452A1 (en) | 2001-11-01 |
| US6656462B2 (en) | 2003-12-02 |
| ATE413191T1 (de) | 2008-11-15 |
| DE60040740D1 (de) | 2008-12-18 |
| EP1196193A2 (en) | 2002-04-17 |
| WO2001039803A2 (en) | 2001-06-07 |
| EP1196193B1 (en) | 2008-11-05 |
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