JP2003514832A - 微粒子製造に関する連続フロー法 - Google Patents

微粒子製造に関する連続フロー法

Info

Publication number
JP2003514832A
JP2003514832A JP2001539061A JP2001539061A JP2003514832A JP 2003514832 A JP2003514832 A JP 2003514832A JP 2001539061 A JP2001539061 A JP 2001539061A JP 2001539061 A JP2001539061 A JP 2001539061A JP 2003514832 A JP2003514832 A JP 2003514832A
Authority
JP
Japan
Prior art keywords
microparticles
emulsion
aqueous
freeze
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001539061A
Other languages
English (en)
Japanese (ja)
Inventor
メアリー リン ヘッドレイ
ユン−イー スウ
マイケル チョウ
Original Assignee
ザイコス インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザイコス インク． filed Critical ザイコス インク．
Publication of JP2003514832A publication Critical patent/JP2003514832A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2001539061A 1999-11-19 2000-11-17 微粒子製造に関する連続フロー法 Pending JP2003514832A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44365499A 1999-11-19 1999-11-19
US09/443,654 1999-11-19
PCT/US2000/031770 WO2001036583A1 (fr) 1999-11-19 2000-11-17 Procede a debit continu permettant de produire des microparticules

Publications (1)

Publication Number Publication Date
JP2003514832A true JP2003514832A (ja) 2003-04-22

Family

ID=23761667

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001539061A Pending JP2003514832A (ja) 1999-11-19 2000-11-17 微粒子製造に関する連続フロー法

Country Status (8)

Country Link
EP (1) EP1230338B1 (fr)
JP (1) JP2003514832A (fr)
AT (1) ATE319810T1 (fr)
AU (1) AU783918B2 (fr)
CA (1) CA2389613A1 (fr)
DE (1) DE60026571T2 (fr)
ES (1) ES2260070T3 (fr)
WO (1) WO2001036583A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515855A (ja) * 2002-12-23 2006-06-08 バイカル インコーポレイテッド 核酸／ブロックコポリマー／陽イオン性界面活性剤複合体を凍結乾燥する方法
JP2007519613A (ja) * 2003-10-23 2007-07-19 アルザ・コーポレーシヨン 微小突出部をコーティングするための安定化されたｄｎａの組成物
JP2008528273A (ja) * 2005-01-25 2008-07-31 ワイス・リサーチ・アイルランド・リミテッド 収集精密ろ過における剪断保護剤
JP2012515790A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド 微粒子製造のための連続二重エマルジョン工程
JP2014224114A (ja) * 2013-05-15 2014-12-04 シージェイ チェイルジェダン コーポレーションＣｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ 連続工程のマイクロスフェアの製造方法及びそれにより製造されたマイクロスフェア

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001093835A1 (fr) * 2000-06-02 2001-12-13 Zycos Inc. Systemes de distribution d'agents bioactifs
JP2006503914A (ja) 2002-10-21 2006-02-02 エムジーアイ ファーマ バイオロジックス インコーポレイテッド ヒトパピローマウイルス媒介性疾患を治療するための組成物および方法
AU2003293196A1 (en) 2002-12-23 2004-07-29 Vical Incorporated Method for producing sterile polynucleotide based medicaments
WO2008054725A2 (fr) 2006-10-31 2008-05-08 Surmodics Pharmaceuticals, Inc. Particules polymères mises sous forme de sphères
JP4900536B2 (ja) * 2009-07-02 2012-03-21 コニカミノルタホールディングス株式会社 特定の分散剤を含有する外水相を利用する二段階乳化法による単胞リポソームの製造方法、ならびに当該単胞リポソームの製造方法を用いる単胞リポソーム分散液またはその乾燥粉末の製造方法
KR102283250B1 (ko) * 2020-12-24 2021-07-29 (주)인벤티지랩 용매 제거 장치 및 이를 이용한 미소구체 제조 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017063A1 (fr) * 1995-11-09 1997-05-15 Microbiological Research Authority Adn microencapsule s'appliquant dans des procedes de vaccination et de therapie genique
WO1999012523A1 (fr) * 1997-09-08 1999-03-18 Skyepharma Inc. Modulation de la charge de medicaments dans des liposomes multivesiculaires
WO1999025319A1 (fr) * 1997-11-14 1999-05-27 Depotech Corporation Production de liposomes multivesiculaires
WO1999030737A1 (fr) * 1997-12-16 1999-06-24 Chiron Corporation Utilisation de microparticules combinees avec des emulsions huile-dans-eau submicroniques
WO1999045966A1 (fr) * 1998-03-13 1999-09-16 American Home Products Corporation Composition polynucleotidique, procede de preparation et utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
GB2310801A (en) * 1996-03-04 1997-09-10 Merck & Co Inc Process for removing an organic solvent from lactide-glycoside copolymer microspheres
ATE359831T1 (de) * 1997-01-22 2007-05-15 Zycos Inc Mikropartikel zur verabreichung von nukleinsaeuren
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
US6020004A (en) * 1997-04-17 2000-02-01 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017063A1 (fr) * 1995-11-09 1997-05-15 Microbiological Research Authority Adn microencapsule s'appliquant dans des procedes de vaccination et de therapie genique
WO1999012523A1 (fr) * 1997-09-08 1999-03-18 Skyepharma Inc. Modulation de la charge de medicaments dans des liposomes multivesiculaires
WO1999025319A1 (fr) * 1997-11-14 1999-05-27 Depotech Corporation Production de liposomes multivesiculaires
WO1999030737A1 (fr) * 1997-12-16 1999-06-24 Chiron Corporation Utilisation de microparticules combinees avec des emulsions huile-dans-eau submicroniques
WO1999045966A1 (fr) * 1998-03-13 1999-09-16 American Home Products Corporation Composition polynucleotidique, procede de preparation et utilisation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515855A (ja) * 2002-12-23 2006-06-08 バイカル インコーポレイテッド 核酸／ブロックコポリマー／陽イオン性界面活性剤複合体を凍結乾燥する方法
JP4917263B2 (ja) * 2002-12-23 2012-04-18 バイカル インコーポレイテッド 核酸／ブロックコポリマー／陽イオン性界面活性剤複合体を凍結乾燥する方法
JP2007519613A (ja) * 2003-10-23 2007-07-19 アルザ・コーポレーシヨン 微小突出部をコーティングするための安定化されたｄｎａの組成物
JP2008528273A (ja) * 2005-01-25 2008-07-31 ワイス・リサーチ・アイルランド・リミテッド 収集精密ろ過における剪断保護剤
JP2012515790A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド 微粒子製造のための連続二重エマルジョン工程
JP2015131843A (ja) * 2009-01-23 2015-07-23 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 微粒子製造のための連続二重エマルジョン法
JP2014224114A (ja) * 2013-05-15 2014-12-04 シージェイ チェイルジェダン コーポレーションＣｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ 連続工程のマイクロスフェアの製造方法及びそれにより製造されたマイクロスフェア

Also Published As

Publication number Publication date
AU783918B2 (en) 2005-12-22
EP1230338A1 (fr) 2002-08-14
DE60026571T2 (de) 2006-12-14
ES2260070T3 (es) 2006-11-01
CA2389613A1 (fr) 2001-05-25
WO2001036583A1 (fr) 2001-05-25
EP1230338A4 (fr) 2004-03-31
AU1623401A (en) 2001-05-30
ATE319810T1 (de) 2006-03-15
DE60026571D1 (de) 2006-05-04
EP1230338B1 (fr) 2006-03-08

Similar Documents

Publication Publication Date Title
US20050037086A1 (en) Continuous-flow method for preparing microparticles
Mundargi et al. Nano/micro technologies for delivering macromolecular therapeutics using poly (D, L-lactide-co-glycolide) and its derivatives
CN112245574B (zh) 一种负载全细胞组分的靶向输送系统及其应用
US20180071387A1 (en) Immunomodulatory compositions comprising a polymer matrix and an oil phase
JP2003535122A (ja) 生物活性物質のための送達システム
AU2001268159A1 (en) Delivery systems for bioactive agents
JP2009261411A (ja) 核酸を輸送するための微粒子
JP2003514832A (ja) 微粒子製造に関する連続フロー法
CN114288398B (zh) 基于全细胞组分的癌症疫苗系统在制备交叉预防或治疗异种癌症药物中的应用
US20020182258A1 (en) Microparticles for delivery of nucleic acid
JP2004502721A (ja) Ｄｎａワクチン送達のためのミクロスフェアおよびアジュバント
US20040053873A1 (en) Electroporation methods for introducing bioactive agents into cells
JP2011088909A (ja) 核酸を送達するための微粒子
CZ20031559A3 (cs) Mikročástice se zlepšeným profilem uvolňování a způsob jejich výroby
EP3842069A1 (fr) Vaccin à base de microcapsule
White et al. Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants
Little et al. Nonviral delivery of cancer genetic vaccines
AU2005201927B2 (en) Microparticles for delivery of nucleic acid
CN116850274A (zh) 一种超声辅助免疫激活的肿瘤疫苗及其制备方法和应用
Lee Melt Processed Polymer/Protein Materials for Sustained Drug Delivery
as Promising Biolological Medicinal Chemistry
WO2012025553A1 (fr) Système d'administration d'un médicament biologique particulaire à libération double contrôlée

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070907

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20090327

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20091009

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100729

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101028

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110128

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110509

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111017