JP2003514576A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003514576A5 JP2003514576A5 JP2001540121A JP2001540121A JP2003514576A5 JP 2003514576 A5 JP2003514576 A5 JP 2003514576A5 JP 2001540121 A JP2001540121 A JP 2001540121A JP 2001540121 A JP2001540121 A JP 2001540121A JP 2003514576 A5 JP2003514576 A5 JP 2003514576A5
- Authority
- JP
- Japan
- Prior art keywords
- hcv
- virus
- immunogenic
- particle
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 description 53
- 229920001184 polypeptide Polymers 0.000 description 39
- 102000004196 processed proteins & peptides Human genes 0.000 description 39
- 108090000765 processed proteins & peptides Proteins 0.000 description 39
- 239000002245 particle Substances 0.000 description 36
- 125000000539 amino acid group Chemical group 0.000 description 21
- 108010076039 Polyproteins Proteins 0.000 description 20
- 108020001507 fusion proteins Proteins 0.000 description 18
- 102000037865 fusion proteins Human genes 0.000 description 18
- 239000000427 antigen Substances 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 239000012634 fragment Substances 0.000 description 10
- 150000007523 nucleic acids Chemical class 0.000 description 10
- 108090000288 Glycoproteins Proteins 0.000 description 8
- 102000003886 Glycoproteins Human genes 0.000 description 8
- 108700008783 Hepatitis C virus E1 Proteins 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 230000004927 fusion Effects 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 102000044437 S1 domains Human genes 0.000 description 1
- 108700036684 S1 domains Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- -1 proteinA nucleic acid Chemical class 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16722499P | 1999-11-24 | 1999-11-24 | |
| US60/167,224 | 1999-11-24 | ||
| PCT/US2000/032249 WO2001038358A2 (en) | 1999-11-24 | 2000-11-22 | Hbv/hcv virus-like particle |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003514576A JP2003514576A (ja) | 2003-04-22 |
| JP2003514576A5 true JP2003514576A5 (enExample) | 2008-01-10 |
| JP4647870B2 JP4647870B2 (ja) | 2011-03-09 |
Family
ID=22606465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001540121A Expired - Lifetime JP4647870B2 (ja) | 1999-11-24 | 2000-11-22 | Ｈｂｖ／ｈｃｖウイルス様粒子 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1233783B9 (enExample) |
| JP (1) | JP4647870B2 (enExample) |
| AT (1) | ATE290399T1 (enExample) |
| AU (1) | AU1928201A (enExample) |
| CA (1) | CA2392527C (enExample) |
| DE (2) | DE60018601D1 (enExample) |
| ES (1) | ES2430368T3 (enExample) |
| WO (1) | WO2001038358A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| EP1476543B1 (en) * | 2002-02-07 | 2014-05-14 | Melbourne Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
| DE10218129A1 (de) * | 2002-04-23 | 2003-11-20 | Univ Ruprecht Karls Heidelberg | Genetischer Impfstoff gegen RNA-Virus-Infektionen |
| US20060240039A1 (en) * | 2003-06-13 | 2006-10-26 | Isis Innovation Limited | Vaccines |
| CA2636139A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| EP2530086B1 (en) | 2006-06-12 | 2019-03-20 | Kuros Biosciences AG | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| US20080166785A1 (en) * | 2006-08-16 | 2008-07-10 | Monica Sala-Schaeffer | Polynucleotides allowing the expression and secretion of recombinant HBsAg virus-like particles containing a foreign peptide, their production and use |
| CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| FR2932388B1 (fr) * | 2008-06-17 | 2013-03-29 | Univ Rabelais Francois | Nouvelles proteines de fusion et leur application pour la preparation de vaccins contre l'hepatite c |
| US9238679B2 (en) * | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| JP2014212722A (ja) * | 2013-04-24 | 2014-11-17 | 学校法人加計学園 | 八面体構造を有するｂ型肝炎ウイルス様粒子結晶 |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| WO2022133230A1 (en) * | 2020-12-18 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098704A (en) * | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
| FR2581394B1 (fr) * | 1985-05-02 | 1988-08-05 | Grp Genie Genetique | Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes |
| KR970010787A (ko) * | 1995-08-14 | 1997-03-27 | 성재갑 | B형 간염 바이러스 표면항원과 c형 간염 바이러스 외피 단백질의 융합 단백질 및 이를 포함하는 혼합 백신 |
-
2000
- 2000-11-22 CA CA2392527A patent/CA2392527C/en not_active Expired - Lifetime
- 2000-11-22 WO PCT/US2000/032249 patent/WO2001038358A2/en not_active Ceased
- 2000-11-22 EP EP00982225A patent/EP1233783B9/en not_active Expired - Lifetime
- 2000-11-22 AT AT00982225T patent/ATE290399T1/de active
- 2000-11-22 AU AU19282/01A patent/AU1928201A/en not_active Abandoned
- 2000-11-22 ES ES04078119T patent/ES2430368T3/es not_active Expired - Lifetime
- 2000-11-22 DE DE60018601A patent/DE60018601D1/de not_active Expired - Lifetime
- 2000-11-22 JP JP2001540121A patent/JP4647870B2/ja not_active Expired - Lifetime
- 2000-11-22 DE DE60018601T patent/DE60018601T4/de not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lazdina et al. | Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent | |
| ES2213754T3 (es) | Particulas quimericas de tipo papilomavirus. | |
| Clarke et al. | Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein | |
| EP1037917B1 (en) | Recombinant nodavirus compositions and methods | |
| JP2003514576A5 (enExample) | ||
| CA2405438A1 (en) | Hepatitis b core antigen fusion proteins | |
| Wizemann et al. | Purification of E. coli-expressed HIS-tagged hepatitis B core antigen by Ni2+-chelate affinity chromatography | |
| JP2006523189A5 (enExample) | ||
| JP2002510494A5 (enExample) | ||
| Ulrich et al. | New chimaeric hepatitis B virus core particles carrying hantavirus (serotype Puumala) epitopes: immunogenicity and protection against virus challenge | |
| JPS63196293A (ja) | 融合蛋白 | |
| Sominskaya et al. | A VLP library of C-terminally truncated Hepatitis B core proteins: correlation of RNA encapsidation with a Th1/Th2 switch in the immune responses of mice | |
| Beames et al. | Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of encapsidated HBV RNA | |
| JP2007525421A (ja) | 慢性肝炎の治療用ワクチンとしての安定化ＨＢｃキメラ粒子 | |
| EP1780285A1 (en) | Improved virus like particles (VLP) based on the small envelope protein of hepatitis B virus (HBsAg-S) | |
| JPH0327400A (ja) | Ｂ型肝炎ウイルスコア抗原粒子 | |
| Mihailova et al. | Recombinant virus-like particles as a carrier of B-and T-cell epitopes of hepatitis C virus (HCV) | |
| Freivalds et al. | Assembly of bacteriophage Qβ virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris | |
| Borisova et al. | Spatial structure and insertion capacity of immunodominant region of hepatitis B core antigen | |
| Pumpens et al. | Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes | |
| JP5656832B2 (ja) | 新規な融合タンパク質及びｃ型肝炎ワクチンの製造のためのその使用 | |
| CN101036784B (zh) | 一种乙型肝炎治疗性细胞毒性t细胞表位疫苗及其制备方法 | |
| Dishlers et al. | The hepatitis B virus core variants that expose foreign C-terminal insertions on the outer surface of virus-like particles | |
| KR101250029B1 (ko) | Ｈｂｖ 감염 또는 ｈｂｖ-매개 질병의 예방/치료를 위한조성물 | |
| WO2001038358A3 (en) | Hbv/hcv virus-like particle |