DE60018601D1 - HBV/HCV Virus-ohnliche Particle - Google Patents
HBV/HCV Virus-ohnliche ParticleInfo
- Publication number
- DE60018601D1 DE60018601D1 DE60018601A DE60018601A DE60018601D1 DE 60018601 D1 DE60018601 D1 DE 60018601D1 DE 60018601 A DE60018601 A DE 60018601A DE 60018601 A DE60018601 A DE 60018601A DE 60018601 D1 DE60018601 D1 DE 60018601D1
- Authority
- DE
- Germany
- Prior art keywords
- virus
- particles
- hbv
- chimeric antigens
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16722499P | 1999-11-24 | 1999-11-24 | |
PCT/US2000/032249 WO2001038358A2 (en) | 1999-11-24 | 2000-11-22 | Hbv/hcv virus-like particle |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60018601D1 true DE60018601D1 (de) | 2005-04-14 |
Family
ID=22606465
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60018601T Expired - Lifetime DE60018601T4 (de) | 1999-11-24 | 2000-11-22 | HBV/HCV Virus-ähnliche Partikel |
DE60018601A Expired - Lifetime DE60018601D1 (de) | 1999-11-24 | 2000-11-22 | HBV/HCV Virus-ohnliche Particle |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60018601T Expired - Lifetime DE60018601T4 (de) | 1999-11-24 | 2000-11-22 | HBV/HCV Virus-ähnliche Partikel |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1233783B9 (de) |
JP (1) | JP4647870B2 (de) |
AT (1) | ATE290399T1 (de) |
AU (1) | AU1928201A (de) |
CA (1) | CA2392527C (de) |
DE (2) | DE60018601T4 (de) |
ES (1) | ES2430368T3 (de) |
WO (1) | WO2001038358A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1450856B1 (de) * | 2001-09-14 | 2009-11-11 | Cytos Biotechnology AG | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
WO2003066841A1 (en) * | 2002-02-07 | 2003-08-14 | Melbourne Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
DE10218129A1 (de) * | 2002-04-23 | 2003-11-20 | Univ Ruprecht Karls Heidelberg | Genetischer Impfstoff gegen RNA-Virus-Infektionen |
WO2004110482A1 (en) * | 2003-06-13 | 2004-12-23 | Isis Innovation Limited | Improved vaccines |
EP1973608A1 (de) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunstimulatorische nukleinsäure-packteilchen zur behandlung von überempfindlichkeit |
AU2007260236B2 (en) | 2006-06-12 | 2013-05-16 | Kuros Us Llc | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
US20080166785A1 (en) * | 2006-08-16 | 2008-07-10 | Monica Sala-Schaeffer | Polynucleotides allowing the expression and secretion of recombinant HBsAg virus-like particles containing a foreign peptide, their production and use |
CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
FR2932388B1 (fr) * | 2008-06-17 | 2013-03-29 | Univ Rabelais Francois | Nouvelles proteines de fusion et leur application pour la preparation de vaccins contre l'hepatite c |
US9238679B2 (en) * | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
JP2014212722A (ja) * | 2013-04-24 | 2014-11-17 | 学校法人加計学園 | 八面体構造を有するb型肝炎ウイルス様粒子結晶 |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
WO2022133230A1 (en) * | 2020-12-18 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098704A (en) * | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
FR2581394B1 (fr) * | 1985-05-02 | 1988-08-05 | Grp Genie Genetique | Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes |
KR970010787A (ko) * | 1995-08-14 | 1997-03-27 | 성재갑 | B형 간염 바이러스 표면항원과 c형 간염 바이러스 외피 단백질의 융합 단백질 및 이를 포함하는 혼합 백신 |
-
2000
- 2000-11-22 CA CA2392527A patent/CA2392527C/en not_active Expired - Lifetime
- 2000-11-22 AU AU19282/01A patent/AU1928201A/en not_active Abandoned
- 2000-11-22 WO PCT/US2000/032249 patent/WO2001038358A2/en active IP Right Grant
- 2000-11-22 AT AT00982225T patent/ATE290399T1/de active
- 2000-11-22 JP JP2001540121A patent/JP4647870B2/ja not_active Expired - Lifetime
- 2000-11-22 DE DE60018601T patent/DE60018601T4/de not_active Expired - Lifetime
- 2000-11-22 ES ES04078119T patent/ES2430368T3/es not_active Expired - Lifetime
- 2000-11-22 DE DE60018601A patent/DE60018601D1/de not_active Expired - Lifetime
- 2000-11-22 EP EP00982225A patent/EP1233783B9/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2430368T3 (es) | 2013-11-20 |
ATE290399T1 (de) | 2005-03-15 |
EP1233783B9 (de) | 2006-03-15 |
JP2003514576A (ja) | 2003-04-22 |
CA2392527C (en) | 2013-09-10 |
CA2392527A1 (en) | 2001-05-31 |
DE60018601T2 (de) | 2006-03-09 |
WO2001038358A3 (en) | 2002-01-10 |
EP1233783A2 (de) | 2002-08-28 |
JP4647870B2 (ja) | 2011-03-09 |
DE60018601T4 (de) | 2008-05-21 |
WO2001038358A2 (en) | 2001-05-31 |
EP1233783B1 (de) | 2005-03-09 |
AU1928201A (en) | 2001-06-04 |
WO2001038358A9 (en) | 2002-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60018601D1 (de) | HBV/HCV Virus-ohnliche Particle | |
Speidel et al. | Priming of cytotoxic T lymphocytes by five heat‐aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses | |
BR0113307A (pt) | Molécula de proteìna quimérica de núcleo de vìrus de hepatite b recombinante, partìcula imunogênica, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, célula hospedeira e método de induzir uma resposta imunológica em um animal hospedeiro inoculado | |
MXPA05009289A (es) | Conjugados de particulas tipo virus del analogo del peptido melan-a. | |
Tang et al. | A modular vaccine development platform based on sortase-mediated site-specific tagging of antigens onto virus-like particles | |
WO2002009645A3 (en) | Intercellular transport protein linked to an antigen as a molecular vaccine | |
CA2405438A1 (en) | Hepatitis b core antigen fusion proteins | |
RU2008106445A (ru) | Вирусоподобные корпускулы (частицы) в качестве противопарамиксовирусной вакцины | |
WO2003068933A3 (en) | Optimization of gene sequences of virus-like particles for expression in insect cells | |
KR880009130A (ko) | 간염 b 바이러스 표면항원 및 이를 함유하는 하이브리드 항원 | |
ES2170622A1 (es) | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. | |
Mihailova et al. | Recombinant virus-like particles as a carrier of B-and T-cell epitopes of hepatitis C virus (HCV) | |
KR880701283A (ko) | Aids의 원인이 되는 비루스의 당단백질을 암호화하는 비루스 벡터, 백신 및 항체 | |
DK1119630T3 (da) | Nukleinsyrekonstruktioner til genetisk immunisering | |
WO2005021713A3 (en) | Vectors expressing sars immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using | |
Akhras et al. | Cell-permeable capsids as universal antigen carrier for the induction of an antigen-specific CD8+ T-cell response | |
CY1107431T1 (el) | Σωματιδια για γoνιδιακη θεραπεια | |
Rueda et al. | Influence of flanking sequences on presentation efficiency of a CD8+ cytotoxic T-cell epitope delivered by parvovirus-like particles | |
JP2003514576A5 (de) | ||
Grabherr et al. | The baculovirus expression system as a tool for generating diversity by viral surface display | |
MY157396A (en) | Novel fusion proteins and use thereof for preparing hepatitis c vaccines | |
Osamu et al. | Purification of hepatitis B virus gene X product synthesized in Escherichia coli and its detection in a human hepatoblastoma cell line producing hepatitis B virus | |
Köck et al. | Duck hepatitis B virus nucleocapsids formed by N-terminally extended or C-terminally truncated core proteins disintegrate during viral DNA maturation | |
EP1535628A3 (de) | HBV/HCV Virus-ähnliche Teilchen | |
WO2006112929A3 (en) | The hiv gp-41-membrane proximal region arrayed on hepatitis b surface antigen particles as novel antigens |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |