JP2003507410A - 乾燥粉末製剤からの放出調節 - Google Patents
乾燥粉末製剤からの放出調節Info
- Publication number
- JP2003507410A JP2003507410A JP2001518029A JP2001518029A JP2003507410A JP 2003507410 A JP2003507410 A JP 2003507410A JP 2001518029 A JP2001518029 A JP 2001518029A JP 2001518029 A JP2001518029 A JP 2001518029A JP 2003507410 A JP2003507410 A JP 2003507410A
- Authority
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- Japan
- Prior art keywords
- particles
- particle
- transition temperature
- phospholipids
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 210000001539 phagocyte Anatomy 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
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- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- AXOIZCJOOAYSMI-UHFFFAOYSA-N succinylcholine Chemical compound C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C AXOIZCJOOAYSMI-UHFFFAOYSA-N 0.000 description 1
- 229940032712 succinylcholine Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US15074299P | 1999-08-25 | 1999-08-25 | |
| US60/150,742 | 1999-08-25 | ||
| PCT/US2000/023048 WO2001013891A2 (en) | 1999-08-25 | 2000-08-23 | Modulation of release from dry powder formulations |
Publications (2)
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| JP2003507410A true JP2003507410A (ja) | 2003-02-25 |
| JP2003507410A5 JP2003507410A5 (enExample) | 2007-04-19 |
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| JP2001518029A Pending JP2003507410A (ja) | 1999-08-25 | 2000-08-23 | 乾燥粉末製剤からの放出調節 |
Country Status (6)
| Country | Link |
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| US (1) | US20040018243A1 (enExample) |
| EP (1) | EP1210067A2 (enExample) |
| JP (1) | JP2003507410A (enExample) |
| AU (1) | AU763041B2 (enExample) |
| CA (1) | CA2382821A1 (enExample) |
| WO (1) | WO2001013891A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006511617A (ja) * | 2002-12-13 | 2006-04-06 | アダーギット | 製薬用多孔質粒子 |
| JP2007500234A (ja) * | 2003-05-28 | 2007-01-11 | ネクター セラピューティクス | 水に不溶な活性剤を含む医薬的成形 |
| JP2009512663A (ja) * | 2005-10-21 | 2009-03-26 | エラテック エス．アール．エル． | 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法 |
| JP2019518782A (ja) * | 2016-06-24 | 2019-07-04 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP2021508734A (ja) * | 2017-12-21 | 2021-03-11 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
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| US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
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| US7141236B2 (en) | 2000-07-28 | 2006-11-28 | Nektar Therapeutics | Methods and compositions for delivering macromolecules to or via the respiratory tract |
| AU2002255181A1 (en) * | 2001-05-21 | 2002-12-03 | Britannia Pharmaceuticals Limited | Use of phospholipids in the treatment of degenerative lung disease such as copd or cystic fibrosis and to enhance delivery of drugs |
| GB0120123D0 (en) * | 2001-08-17 | 2001-10-10 | Upperton Ltd | Preparation of microparticles |
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| EP1458361A4 (en) * | 2001-11-20 | 2007-04-25 | Advanced Inhalation Res Inc | COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT |
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| EP1486204A1 (en) * | 2002-03-18 | 2004-12-15 | Yamanouchi Pharmaceutical Co. Ltd. | Powdery medicinal compositions for inhalation and process for producing the same |
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| WO2006124446A2 (en) * | 2005-05-12 | 2006-11-23 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
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| CA2926793C (en) * | 2013-10-11 | 2022-11-22 | Lawrence S. ZISMAN | Spray-dry formulations for treating pulmonary arterial hypertension |
| US20150224202A1 (en) * | 2014-02-03 | 2015-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Formulations and uses for microparticle delivery of zinc protoporphyrins |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006511617A (ja) * | 2002-12-13 | 2006-04-06 | アダーギット | 製薬用多孔質粒子 |
| JP2007500234A (ja) * | 2003-05-28 | 2007-01-11 | ネクター セラピューティクス | 水に不溶な活性剤を含む医薬的成形 |
| JP2009512663A (ja) * | 2005-10-21 | 2009-03-26 | エラテック エス．アール．エル． | 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法 |
| US9138407B2 (en) | 2005-10-21 | 2015-09-22 | Eratech S.R.L. | Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions obtained from the same and process for their preparation |
| JP2019518782A (ja) * | 2016-06-24 | 2019-07-04 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP7240178B2 (ja) | 2016-06-24 | 2023-03-15 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP2023071886A (ja) * | 2016-06-24 | 2023-05-23 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP7629159B2 (ja) | 2016-06-24 | 2025-02-13 | メルツ ファーマスーティカルズ， エルエルシー | 吸入用サーファクタント製剤 |
| JP2021508734A (ja) * | 2017-12-21 | 2021-03-11 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
| JP7335263B2 (ja) | 2017-12-21 | 2023-08-29 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6925900A (en) | 2001-03-19 |
| CA2382821A1 (en) | 2001-03-01 |
| WO2001013891A3 (en) | 2001-07-26 |
| AU763041B2 (en) | 2003-07-10 |
| EP1210067A2 (en) | 2002-06-05 |
| WO2001013891A2 (en) | 2001-03-01 |
| US20040018243A1 (en) | 2004-01-29 |
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