JP2003507393A - 改変された毛様体神経栄養因子、それらを作製する方法およびそれらの使用方法 - Google Patents

改変された毛様体神経栄養因子、それらを作製する方法およびそれらの使用方法

Info

Publication number
JP2003507393A
JP2003507393A JP2001517694A JP2001517694A JP2003507393A JP 2003507393 A JP2003507393 A JP 2003507393A JP 2001517694 A JP2001517694 A JP 2001517694A JP 2001517694 A JP2001517694 A JP 2001517694A JP 2003507393 A JP2003507393 A JP 2003507393A
Authority
JP
Japan
Prior art keywords
cntf
mammal
rhcntf
mice
neurons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001517694A
Other languages
English (en)
Japanese (ja)
Inventor
スタンリー ジェイ. ウィーガンド,
マーク ダブリュー. スリーマン,
フィリップ ディー. ランバート,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/454,380 external-priority patent/US6680291B1/en
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of JP2003507393A publication Critical patent/JP2003507393A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001517694A 1999-08-13 2000-07-27 改変された毛様体神経栄養因子、それらを作製する方法およびそれらの使用方法 Withdrawn JP2003507393A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37383499A 1999-08-13 1999-08-13
US09/373,834 1999-08-13
US09/454,380 US6680291B1 (en) 1998-02-27 1999-12-03 Modified ciliary neurotrophic factor, method of making and methods of use thereof
US09/454,380 1999-12-03
PCT/US2000/020432 WO2001012810A1 (en) 1999-08-13 2000-07-27 Modified ciliary neurotrophic factor, method of making and methods of use thereof

Publications (1)

Publication Number Publication Date
JP2003507393A true JP2003507393A (ja) 2003-02-25

Family

ID=27006327

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001517694A Withdrawn JP2003507393A (ja) 1999-08-13 2000-07-27 改変された毛様体神経栄養因子、それらを作製する方法およびそれらの使用方法

Country Status (10)

Country Link
EP (1) EP1200589A1 (zh)
JP (1) JP2003507393A (zh)
CN (1) CN1387568A (zh)
AU (1) AU6382200A (zh)
BR (1) BR0013204A (zh)
CA (1) CA2379940A1 (zh)
HU (1) HUP0203057A3 (zh)
IL (1) IL148033A0 (zh)
PL (1) PL364931A1 (zh)
WO (1) WO2001012810A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030081480A (ko) * 2001-03-02 2003-10-17 메르크 파텐트 게엠베하 감소된 면역원성을 갖는 변형된 모양체 신경자극 인자(cntf)
CN100439396C (zh) * 2004-04-02 2008-12-03 西南生物工程产业化中试基地有限公司 人睫状神经营养因子的衍生物多肽及其制备方法和应用
CN100457778C (zh) * 2005-09-02 2009-02-04 中国药品生物制品检定所 睫状神经营养因子(cntf)突变体及其生产方法和其用途
CN101144082B (zh) * 2007-06-12 2012-09-05 兰州生物制品研究所有限责任公司 重组人睫状神经营养因子、突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors
US6472178B1 (en) * 1998-02-27 2002-10-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
US6391312B1 (en) * 1997-01-23 2002-05-21 Sumitomo Pharmaceuticals Co., Limited Remedies for diabetes

Also Published As

Publication number Publication date
BR0013204A (pt) 2004-02-17
EP1200589A1 (en) 2002-05-02
WO2001012810A1 (en) 2001-02-22
AU6382200A (en) 2001-03-13
PL364931A1 (en) 2004-12-27
CN1387568A (zh) 2002-12-25
HUP0203057A3 (en) 2005-07-28
IL148033A0 (en) 2002-09-12
HUP0203057A2 (hu) 2002-12-28
CA2379940A1 (en) 2001-02-22

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Legal Events

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A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20071002