JP2003507356A - 血管損傷活性を有する新しいスチルベン類 - Google Patents
血管損傷活性を有する新しいスチルベン類Info
- Publication number
- JP2003507356A JP2003507356A JP2001516880A JP2001516880A JP2003507356A JP 2003507356 A JP2003507356 A JP 2003507356A JP 2001516880 A JP2001516880 A JP 2001516880A JP 2001516880 A JP2001516880 A JP 2001516880A JP 2003507356 A JP2003507356 A JP 2003507356A
- Authority
- JP
- Japan
- Prior art keywords
- cis
- stilbene
- compounds
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9918912.8A GB9918912D0 (en) | 1999-08-12 | 1999-08-12 | New stilbenes with vascular damaging activity |
| GB9918912.8 | 1999-08-12 | ||
| PCT/GB2000/003067 WO2001012579A2 (en) | 1999-08-12 | 2000-08-09 | New stilbenes with vascular damaging activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003507356A true JP2003507356A (ja) | 2003-02-25 |
Family
ID=10858950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001516880A Pending JP2003507356A (ja) | 1999-08-12 | 2000-08-09 | 血管損傷活性を有する新しいスチルベン類 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1206429A2 (it) |
| JP (1) | JP2003507356A (it) |
| CA (1) | CA2379544A1 (it) |
| GB (1) | GB9918912D0 (it) |
| NZ (1) | NZ517069A (it) |
| WO (1) | WO2001012579A2 (it) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008506722A (ja) * | 2004-07-21 | 2008-03-06 | 中国人民解放▲軍▼▲軍▼事医学科学院放射医学研究所 | シス−１，２−置換スチルベン誘導体、および糖尿病の治療および／または予防のための薬剤の製造におけるそれらの使用 |
| JP2009539779A (ja) * | 2006-06-06 | 2009-11-19 | ジョーアジアーン ダードーア ファーマスーティカル グループ カンパニー リミテッド | フルオロアルコキシコンブレタスタチン誘導体とその製造方法及び用途 |
| JP2011016777A (ja) * | 2009-07-10 | 2011-01-27 | Nipro Corp | 新規システイン誘導体 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1068870B1 (en) | 1998-04-03 | 2006-06-07 | Ajinomoto Co., Inc. | Antitumor agents |
| GB0019944D0 (en) * | 2000-08-15 | 2000-09-27 | Angiogene Pharm Ltd | Compositions with vascular damaging activity |
| AU2002216228A1 (en) * | 2000-12-21 | 2002-07-01 | Cancer Research Ventures Limited | Substituted stilbenes, their reactions and anticancer activity |
| FR2838437B1 (fr) | 2002-04-11 | 2004-06-04 | Aventis Pharma Sa | Procedes de preparation de combretastatines |
| GB0306908D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
| EP1631540A4 (en) * | 2003-12-16 | 2006-10-04 | Gtx Inc | PRODRUGS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD OF USE THEREOF |
| PL2219451T3 (pl) | 2007-11-21 | 2015-04-30 | Oxigene Inc | Sposób leczenia nowotworów tkanek krwiotwórczych |
| WO2012025638A1 (en) | 2010-08-27 | 2012-03-01 | Universität des Saarlandes | Selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| WO2017031157A1 (en) | 2015-08-18 | 2017-02-23 | Mateon Therapeutics, Inc. | Use of vdas to enhance immunomodulating therapies against tumors |
| WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| WO2020092134A1 (en) | 2018-10-29 | 2020-05-07 | Cepheid | Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| TW325458B (en) * | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| GB9903403D0 (en) * | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Substituted stilbene compounds with vascular damaging activity |
-
1999
- 1999-08-12 GB GBGB9918912.8A patent/GB9918912D0/en not_active Ceased
-
2000
- 2000-08-09 NZ NZ517069A patent/NZ517069A/en unknown
- 2000-08-09 EP EP00951727A patent/EP1206429A2/en not_active Withdrawn
- 2000-08-09 WO PCT/GB2000/003067 patent/WO2001012579A2/en not_active Application Discontinuation
- 2000-08-09 JP JP2001516880A patent/JP2003507356A/ja active Pending
- 2000-08-09 CA CA002379544A patent/CA2379544A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008506722A (ja) * | 2004-07-21 | 2008-03-06 | 中国人民解放▲軍▼▲軍▼事医学科学院放射医学研究所 | シス−１，２−置換スチルベン誘導体、および糖尿病の治療および／または予防のための薬剤の製造におけるそれらの使用 |
| US8039513B2 (en) | 2004-07-21 | 2011-10-18 | Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla | Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes |
| JP2009539779A (ja) * | 2006-06-06 | 2009-11-19 | ジョーアジアーン ダードーア ファーマスーティカル グループ カンパニー リミテッド | フルオロアルコキシコンブレタスタチン誘導体とその製造方法及び用途 |
| JP2011016777A (ja) * | 2009-07-10 | 2011-01-27 | Nipro Corp | 新規システイン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9918912D0 (en) | 1999-10-13 |
| CA2379544A1 (en) | 2001-02-22 |
| EP1206429A2 (en) | 2002-05-22 |
| WO2001012579A2 (en) | 2001-02-22 |
| WO2001012579A3 (en) | 2001-10-11 |
| NZ517069A (en) | 2004-04-30 |
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